Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology

Autor: Pierre A. Kyme, Lihong Guo, Wenyuan Shi, Xuesong He, Youngik Yang, Brian C. Varnum, Christopher W. Kaplan, Omid Sheikh, Jeffrey S. McLean, Renate Lux, Randal H. Eckert

Publikováno v: Proceedings of the National Academy of Sciences. 112:7569-7574

One major challenge to studying human microbiome and its associated diseases is the lack of effective tools to achieve targeted modulation of individual species and study its ecological function within multispecies communities. Here, we show that C16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80112f6b03d935dd9e2387b10372e48
https://doi.org/10.1073/pnas.1506207112

Systematic Approach to Optimizing Specifically Targeted Antimicrobial Peptides against Streptococcus mutans

Autor: Daniel K. Yarbrough, Jens Kreth, Wenyuan Shi, Jian He, Randal H. Eckert, Maxwell H. Anderson

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:2143-2151

Previously we reported a novel strategy of “targeted killing” through the design of narrow-spectrum molecules known as specifically targeted antimicrobial peptides (STAMPs) (R. Eckert et al., Antimicrob. Agents Chemother. 50:3651-3657, 2006; R. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2d205a3f7019fb87b4046f56901a12
https://doi.org/10.1128/aac.01391-09

Design and Characterization of an Acid-Activated Antimicrobial Peptide

Autor: Lina Li, Wenyuan Shi, Daniel K. Yarbrough, Jian He, Renate Lux, Maxwell H. Anderson, Randal H. Eckert

Publikováno v: Chemical Biology & Drug Design. 75:127-132

Dental caries is a microbial biofilm infection in which the metabolic activities of plaque bacteria result in a dramatic pH decrease and shift the demineralization/remineralization equilibrium on the tooth surface towards demineralization. In additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edf20a2d99e6724680a6bc6cfbcf715
https://doi.org/10.1111/j.1747-0285.2009.00904.x

Adding Selectivity to Antimicrobial Peptides: Rational Design of a Multidomain Peptide against Pseudomonas spp

Autor: Daniel K. Yarbrough, Fengxia Qi, Wenyuan Shi, Randal H. Eckert, Jian He, Maxwell H. Anderson

Publikováno v: Antimicrobial Agents and Chemotherapy. 50:1480-1488

Currently available antimicrobials exhibit broad killing with regard to bacterial genera and species. Indiscriminate killing of microbes by these conventional antibiotics can disrupt the ecological balance of the indigenous microbial flora, often res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88629f3f846b91f65bdd48cbec95e1d9
https://doi.org/10.1128/aac.50.4.1480-1488.2006

Specific Binding and Mineralization of Calcified Surfaces by Small Peptides

Autor: Jian He, Bruce Rutherford, Hyewon Choi, Sotiris Tetradis, Elizabeth Hagerman, Nga Cao, Wenyuan Shi, Fengxia Qi, Daniel K. Yarbrough, Jennifer Hedger, Ben Wu, Maxwell H. Anderson, Karen Le, Randal H. Eckert

Publikováno v: Yarbrough, Daniel K.; Hagerman, Elizabeth; Eckert, Randal; He, Jian; Choi, Hyewon; Cao, Nga; et al.(2010). Specific Binding and Mineralization of Calcified Surfaces by Small Peptides. Calcified Tissue International, 86(1), pp 58-66. doi: 10.1007/s00223-009-9312-0. Retrieved from: http://www.escholarship.org/uc/item/0vt2b52n
Calcified Tissue International

Several small (25aa) peptides have been designed based on the sequence of the dentin phosphoprotein, one of the major noncollagenous proteins thought to be involved in the mineralization of the dentin extracellular matrix during tooth development. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d69700adf6618b1cb33d20b17b2f3a
http://www.escholarship.org/uc/item/0vt2b52n