Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Randa S. Eshaq"'
Publikováno v:
Pathophysiology, Vol 31, Iss 1, Pp 89-99 (2024)
Our purpose in this study was to identify the role played by oxidative stress in the changes to proteoglycans that occur under hyperglycemic conditions, using primary rat retinal microvascular endothelial cells (RRMEC) and cultured ophthalmic arterie
Externí odkaz:
https://doaj.org/article/2f733c3fa029408ca8338ea218c89fe0
Publikováno v:
Veins and Lymphatics, Vol 11, Iss 1 (2022)
Background: Hypertension (HT) promotes structural and functional changes in the cerebral microcirculation that can provoke irreversible cerebrovascular injury, leading to neuronal loss and brain atrophy,1 cognitive impairment, vascular dementia,2 and
Externí odkaz:
https://doaj.org/article/267b63f8c7324a58a92cdfa23fb340a6
Autor:
Randa S. Eshaq, Megan N. Watts, Patsy R. Carter, Wendy Leskova, Tak Yee Aw, Jonathan Steven Alexander, Norman R. Harris
Publikováno v:
Pathophysiology, Vol 28, Iss 1, Pp 86-97 (2021)
Angiotensin II has been implicated in the progression of diabetic retinopathy, which is characterized by altered microvasculature, oxidative stress, and neuronal dysfunction. The signaling induced by angiotensin II can occur not only via receptor-med
Externí odkaz:
https://doaj.org/article/118759fd903a4f278fd1d41050f107b9
Autor:
Mansoureh Barzegar, Yuping Wang, Randa S. Eshaq, J. Winny Yun, Christen J. Boyer, Sergio G. Cananzi, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Alireza Minagar, Karen Y. Stokes, Xiao-Hong Lu, Jonathan S. Alexander
Publikováno v:
EBioMedicine, Vol 63, Iss , Pp 103161- (2021)
Background: Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. Howeve
Externí odkaz:
https://doaj.org/article/d89ea5f8faa2468dbd0a87084b80f2be
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 661-666 (2014)
Retinal tissue receives its supply of oxygen from two sources – the retinal and choroidal circulations. Decreases in retinal blood flow occur in the early stages of diabetes, with the eventual development of hypoxia thought to contribute to patholo
Externí odkaz:
https://doaj.org/article/a3e25f1dbc54483e8e218e8f51ce1a16
Autor:
Patsy R. Carter, Tak Yee Aw, Megan N. Watts, Norman R. Harris, Wendy Leskova, Randa S. Eshaq, Jonathan Steven Alexander
Publikováno v:
Pathophysiology, Vol 28, Iss 8, Pp 86-97 (2021)
Pathophysiology
Volume 28
Issue 1
Pages 8-97
Pathophysiology
Volume 28
Issue 1
Pages 8-97
Angiotensin II has been implicated in the progression of diabetic retinopathy, which is characterized by altered microvasculature, oxidative stress, and neuronal dysfunction. The signaling induced by angiotensin II can occur not only via receptor-med
Publikováno v:
Comprehensive Physiology
Compr Physiol
Compr Physiol
In this article, we present a discussion of diabetes and its complications, including the macrovascular and microvascular effects, with the latter of consequence to the retina. We will discuss the anatomy and physiology of the retina, including aspec
Autor:
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Cynthia eMoore, Rebecca L. Hood, Nancy Jo Leidenheimer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents. Both the effica
Externí odkaz:
https://doaj.org/article/403b6372a3f2401389e711280240f87b
Autor:
Norman R. Harris, Randa S. Eshaq
Publikováno v:
Microcirculation
Objective This study aimed to investigate the role of the hyperglycemia-induced increase in tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the ubiquitination and degradation of platelet endothelial cell adhesion molecule-1 (PECAM-1)
Autor:
Norman R. Harris, Randa S. Eshaq
Publikováno v:
Microcirculation. 27
Objective Increased retinal vascular permeability is one of the earliest manifestations of diabetic retinopathy. The aim of this study was to investigate the role of hyperglycemia-induced platelet endothelial cell adhesion molecule-1 loss on retinal