Výsledky vyhledávání - "Randa E. Yee"

Novel observations with FDOPA-PET imaging after early nigrostriatal damage

Autor: Daniel M. Togasaki, I Irwin, C Milonas, Keyvan Farahani, Ann Marie Janson, J. W. Langston, Nagichettiar Satyamurthy, Louis E. DeLanney, Michael E. Phelps, David B. Stout, K Delfani, Jorge R. Barrio, Randa E. Yee, Kooresh Shoghi-Jadid, S.-C. Huang

Publikováno v: Movement Disorders. 16:838-848

Striatal 6-[ 18 F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3f8e6a46f2b7273deb3beece07eeafb
https://doi.org/10.1002/mds.1168

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Distribution Volume of 3-O-methyl-6-[F-18]FDOPA in Rat Brain

Autor: Sung-Cheng Huang, Jorge R. Barrio, Randa E. Yee, Nagichettiar Satyamurthy, David B. Stout, Mohammad Namavari

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 20:1717-1724

The distribution volume (DY) of 6-[F-18]fluoro-L-DOPA (FDOPA) in the cerebellum recently has been linked using positron emission tomography (PET) to plasma large neutral amino acid (LNAA) concentrations in monkeys. In this article the authors provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebd8a061b48d2eaf143b43e364ffe28f
https://doi.org/10.1097/00004647-200012000-00011

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Striatal Kinetic Modeling of FDOPA with a Cerebellar-Derived Constraint on the Distribution Volume of 3OMFD: A PET Investigation using Non-Human Primates

Autor: Michael E. Phelps, Randa E. Yee, David B. Stout, Kooresh Shoghi-Jadid, Sung-Cheng Huang, Eric Yeh, Keyvan Farahani, Jorge R. Barrio, Nagichettiar Satyamurthy

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 20:1134-1148

The peripherally born metabolite of FDOPA, 3-O-Methyl-FDOPA (3OMFD), crosses the blood-brain barrier, thus complicating positron emission tomography-FDOPA (PET-FDOPA) data analysis. In previous reports the distribution volume (DV) of 3OMFD was constr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24855a2331e579225a493497a9176f7d
https://doi.org/10.1097/00004647-200007000-00012

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Distribution Volume of Radiolabeled Large Neutral Amino Acids in Brain Tissue

Autor: Sung-Cheng Huang, David B. Stout, Jorge R. Barrio, Randa E. Yee, Nagichettiar Satyamurthy

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 18:1288-1293

Variations in the cerebellum to plasma ratio at late times in 6-[18F]fluoro-l-DOPA studies are shown to be consistent with competitive binding of large neutral amino acids for a common transporter in the blood—brain barrier and the stability of bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0747165be59536263598e0041f9872
https://doi.org/10.1097/00004647-199812000-00002

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Imaging and therapeutics: the role of neuronal transport in the regional specificity of L-DOPA accumulation in brain

Autor: Randa E. Yee, Nagichettiar Satyamurthy, Daniel M. Togasaki, Sung-Chen Huang, Jorge R. Barrio, J. William Langston

Publikováno v: Molecular imaging and biology. 4(3)

Purpose: To investigate the in vitro regional accumulation of L-3,4-dihydroxyphenylalanine (L-DOPA) in brain tissue. Procedure: Neuronal membrane transport of L-DOPA was investigated in rat and squirrel monkey brain tissue. The kinetics of L-DOPA reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d620c8dfcc2697f7d38c36163dcd7b9
https://pubmed.ncbi.nlm.nih.gov/14537125

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Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: in vivo and in vitro investigations

Autor: Jorge R. Barrio, Michael E. Phelps, Louis E. DeLanney, D.M. Togaski, Nagichettiar Satyamurthy, Kooresh Shoghi-Jadid, Keyvan Farahani, Sung-Cheng Huang, J.W. Langston, Randa E. Yee, David B. Stout, Ian Irwin

Publikováno v: Journal of neurochemistry. 74(3)

Aromatic L-amino acid decarboxylase (AAAD) activity was examined in vivo with positron emission tomography (PET) using 6-[18F]fluoro-L-DOPA (FDOPA) in squirrel monkeys lesioned with graded doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65eb240db28f32580fe981943d96e2aa
https://pubmed.ncbi.nlm.nih.gov/10693947

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