Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Randáková A"'
Autor:
Dominik Nelic, Nikolai Chetverikov, Martina Hochmalová, Christina Diaz, Vladimír Doležal, John Boulos, Jan Jakubík, Kirill Martemyanov, Alena Janoušková-Randáková
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Selective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well. The flexible G-protein interface of m
Externí odkaz:
https://doaj.org/article/03ce4b98fb3949499a075156508c3010
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Agonist efficacy denoting the “strength” of agonist action is a cornerstone in the proper assessment of agonist selectivity and signalling bias. The simulation models are very accurate but complex and hard to fit experimental data. The p
Externí odkaz:
https://doaj.org/article/93e657224a974635a025309073addb3d
Autor:
Randáková, Alena1 (AUTHOR), Nelic, Dominik1 (AUTHOR), Jakubík, Jan1 (AUTHOR) jan.jakubik@fgu.cas.cz
Publikováno v:
Scientific Reports. 10/16/2023, Vol. 13 Issue 1, p1-15. 15p.
Autor:
Juza, Radomir, Vojtechova, Iveta, Stefkova-Mazochova, Kristyna, Dehaen, Wim, Petrasek, Tomas, Prchal, Lukas, Kobrlova, Tereza, Janousek, Jiri, Vlcek, Premysl, Mezeiova, Eva, Svozil, Daniel, Karasova, Jana Zdarova, Pejchal, Jaroslav, Stark, Holger, Satala, Grzegorz, Bojarski, Andrzej J., Kubacka, Monika, Mogilski, Szczepan, Randakova, Alena, Musilek, Kamil, Soukup, Ondrej, Korabecny, Jan
Publikováno v:
In European Journal of Medicinal Chemistry 15 March 2022 232
Akademický článek
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Publikováno v:
Heritage Science, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract The Bohemian historical glasses have been neglected and have not been in focus of Archaeometric studies so far. Potassium-calcium wood ash glasses, produced in Bohemia and Moravia, from the beginning of the 14th century to the first half of
Externí odkaz:
https://doaj.org/article/62001a41f75b45308e7a04f735a281d3
Autor:
Ewa Szczurowska, Eszter Szánti-Pintér, Nikolai Chetverikov, Alena Randáková, Eva Kudová, Jan Jakubík
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 507 (2022)
Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditi
Externí odkaz:
https://doaj.org/article/1ba22ba0a7a84192b0a6a42c5d1c8e16
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13075 (2022)
Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurostero
Externí odkaz:
https://doaj.org/article/55e89d5dab5446babb00af227aef3ed0
Autor:
Alena Randáková, Dominik Nelic, Martina Hochmalová, Pavel Zimčík, Mutale Jane Mulenga, John Boulos, Jan Jakubík
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10089 (2021)
A complex evaluation of agonist bias at G-protein coupled receptors at the level of G-protein classes and isoforms including non-preferential ones is essential for advanced agonist screening and drug development. Molecular crosstalk in downstream sig
Externí odkaz:
https://doaj.org/article/02b106b875504802b6a348b058fbf887
Publikováno v:
Minerals, Vol 11, Iss 9, p 1001 (2021)
The study deals with the development of the chemical composition of blue glass from the 13th to the 19th century in the region of Bohemia (Central Europe). Nearly 100 glass samples (colourless, greenish, and blue) were evaluated by an XRF method to d
Externí odkaz:
https://doaj.org/article/6c172de633914d5abc86f46060e0fa4b