Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

Autor: Sonnenkalb, Lindsay, Carter, Joshua James, Spitaleri, Andrea, Iqbal, Zamin, Hunt, Martin, Malone, Kerri Marie, Utpatel, Christian, Cirillo, Daniela Maria, Rodrigues, Camilla, Nilgiriwala, Kayzad Soli, Fowler, Philip William, Merker, Matthias, Niemann, Stefan, Consortium, The Comprehensive Resistance Prediction for Tuberculosis: an International, Barilar, I, Battaglia, S, Borroni, E, Brandao, AP, Brankin, A, Cabibbe, AM, Carter, J, Claxton, P, Clifton, DA, Cohen, T, Coronel, J, Crook, DW, Dreyer, V, Earle, SG, Escuyer, V, Ferrazoli, L, Fowler, PW, Gao, G Fu, Gardy, J, Gharbia, S, Ghisi, KT, Ghodousi, A, Cruz, AL Gibertoni, Grandjean, L, Grazian, C, Groenheit, R, Guthrie, JL, He, W, Hoffmann, H, Hoosdally, SJ, Ismail, NA, Jarrett, L, Joseph, L, Jou, R, Kambli, P, Khot, R, Knaggs, J, Koch, A, Kohlerschmidt, D, Kouchaki, S, Lachapelle, AS, Lalvani, A, Lapierre, S Grandjean, Laurenson, IF, Letcher, B, Lin, WH, Liu, C, Liu, D, Malone, KM, Mandal, A, Mansjö, M, Matias, D, Meintjes, G, de Freitas Mendes, F, Mihalic, M, Millard, J, Miotto, P, Mistry, N, Moore, D, Musser, KA, Ngcamu, D, Hoang, NN, Nimmo, C, Okozi, N, Oliveira, RS, Omar, SV, Paton, N, Peto, TE, Pinhata, JM Watanabe, Plesnik, S, Puyen, ZM, Rabodoarivelo, MS, Rakotosamimanana, N, Rancoita, PM, Rathod, P, Rodger, G, Rodwell, TC, Roohi, E, Santos-Lazaro, D, Shah, S, Kohl, TA, Smith, G, Solano, W, Supply, P, Surve, U, Tahseen, S, Thuong, NTT

Background: Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3dc1aaf8f396193628850666e402b6

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

Autor: Silvia Uccella, Miguel A. Piris, Maria Grazia Tibiletti, Francesco Forconi, Silvia Franceschetti, Ivo Kwee, Roberto Marasca, Francesco Bertoni, Riccardo Dalla Favera, Catherine Thieblemont, Stephan Dirnhofer, Cassio P. de Campos, Fabio Facchetti, Randy D. Gascoyne, Claudio Tripodo, Valter Gattei, Paola M.V. Rancoita, Gianluca Gaidano, Govind Bhagat, Luca Baldini, Luca Arcaini, Jean Soulier, Claudio Doglioni, Alessandra Tucci, Manuela Mollejo, Emanuele Zucca, Urban Novak, Michael Mian, Silvia Govi, Andrea Rinaldi, Vincenzo Canzonieri, Andrés J.M. Ferreri, Ekaterina Chigrinova, Maurilio Ponzoni, Franco Cavalli

Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4335a18c577296a57f87c2539350c07
https://hdl.handle.net/11380/695060

Preliminary data of a large study of high-resolution genome wide-DNA profiling in marginal zone lymphomas (MZL)

Autor: Bertoni, F., Favera, R. Dalla, Gascoyne, R. D., Piris, M. A., Zucca, E., Tibiletti, M. G., Doglioni, C., Carbone, A., Pruneri, G., Forconi, F., Thieblemont, C., Soulier, J., Gloghini, A., Vincenzo Canzonieri, Gattei, V., Baldini, L., Dirnhofer, S., Facchetti, F., Mollejo, M., Marasca, R., Gaidano, G., Nandula, S. V., Murty, V. V., Novak, U., Bhagat, G., Ponzoni, M., Rancoita, P. M., Kwee, I., Rinaldi, A.

Publikováno v: Publons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1ab0a26ff375474e9b83f46d6ad665ef
https://publons.com/publon/5920678/

Italian reference values and brain correlates of verbal fluency index - vs standard verbal fluency test - to assess executive dysfunction in ALS.

Autor: Canu E; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Castelnovo V; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rancoita PM; University Centre for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy., Leocadi M; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Lamanuzzi A; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Spinelli EG; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Basaia S; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Riva N; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Poletti B; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy., Solca F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy., Verde F; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Abrahams S; Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK, and., Filippi M; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy., Agosta F; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Publikováno v: Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2023 Aug; Vol. 24 (5-6), pp. 457-465. Date of Electronic Publication: 2023 Jan 18.

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

Autor: Vavassori V; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Mercuri E; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Milano-Bicocca University, Monza, Italy., Marcovecchio GE; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Castiello MC; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Institute of Genetic and Biomedical Research Milan Unit, National Research Council (CNR), Milan, Italy., Schiroli G; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Albano L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Margulies C; Editas Medicine, Cambridge, MA, USA., Buquicchio F; Editas Medicine, Cambridge, MA, USA., Fontana E; Institute of Genetic and Biomedical Research Milan Unit, National Research Council (CNR), Milan, Italy.; Human Genome Lab, Humanitas Clinical and Research Center, Milan, Italy., Beretta S; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy., Merelli I; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Institute for Biomedical Technologies, National Research Council (CNR), Segrate, Italy., Cappelleri A; Mouse and Animal Pathology Laboratory (MAPLab), Fondazione Unimi, Milano, Italy.; Department of Veterinary Medicine, University of Milan, Milan, Italy., Rancoita PM; University Center for Statistics in the Biomedical Sciences (CUSSB), Vita-Salute San Raffaele University, Milan, Italy., Lougaris V; University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy., Plebani A; University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy., Kanariou M; First Department of Paediatrics, Aghia Sophia Children's Hospital, Athens, Greece., Lankester A; Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands., Ferrua F; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scanziani E; Mouse and Animal Pathology Laboratory (MAPLab), Fondazione Unimi, Milano, Italy.; Department of Veterinary Medicine, University of Milan, Milan, Italy., Cotta-Ramusino C; Editas Medicine, Cambridge, MA, USA., Villa A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Institute of Genetic and Biomedical Research Milan Unit, National Research Council (CNR), Milan, Italy., Naldini L; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Genovese P; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2021 Mar 05; Vol. 13 (3), pp. e13545. Date of Electronic Publication: 2021 Jan 21.