Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Rance Nault"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that disrupts hepatic function leading to steatotic liver disease (SLD)-like pathologies, such as steatosis, steatohepatitis, and fibrosis. These effects ar
Externí odkaz:
https://doaj.org/article/fb48d6e31421443c87289a33eda499ff
Autor:
Stephanie W. Watts, Janice M. Thompson, Sudin Bhattacharya, Vishal Panda, Leah Terrian, Andres Contreras, Rance Nault
Publikováno v:
Pharmacological Research, Vol 206, Iss , Pp 107269- (2024)
Perivascular adipose tissue (PVAT) is known for being anti-contractile in healthy tissues. We discovered a new function of PVAT, the ability to stress relax and maintain a tone in response to a stretch. This is of note because stress relaxation has b
Externí odkaz:
https://doaj.org/article/800850cde53a4fda8e235fbd08cddc8e
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with metabolic syndrome (MetS) in humans and elicits pathologies in rodents that resemble non-alcoholic fatty liver disease (NAFLD) in humans through activation of the aryl hydrocarbon
Externí odkaz:
https://doaj.org/article/6ca555dc30684b499a04f452103b3251
Autor:
Giovan N. Cholico, Karina Orlowska, Russell R. Fling, Warren J. Sink, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Tim Zacharewski
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice. Furthermore, TCDD reprograms hepatic metabolism by redirecting glycolyti
Externí odkaz:
https://doaj.org/article/b4286f4e342e494dbb3d2ec0f8e1f9fb
Autor:
Giovan N. Cholico, Russell R. Fling, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Timothy R. Zacharewski
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis by increasing hepatic uptake of dietary and mobilized peripheral fats, inhibiting lipoprotein export, and repressing β-oxidation. In this
Externí odkaz:
https://doaj.org/article/c45e1cdb4ce34f019fc7bb449eff6b5a
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 147-159 (2021)
Background and Aims: Characterization of cell specific transcriptional responses to hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-seq technologies enable the transcriptomes of individual cell (sub)ty
Externí odkaz:
https://doaj.org/article/4d0bc72997e944adb26d2a828d699443
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Abstract Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines the effects of
Externí odkaz:
https://doaj.org/article/9a17274562514ae6a763ae55659ce0bb
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1558 (2022)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known for mediating the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Although the canonical mechanism of AhR activation involves heterodim
Externí odkaz:
https://doaj.org/article/36d622061eba4507a2c5669862309c83
Autor:
Kelly A. Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R. Harkema, Timothy R. Zacharewski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01–30 µg/kg) every
Externí odkaz:
https://doaj.org/article/dfa70fdef3ce4540b2a3007793bde343
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184842 (2017)
The aryl hydrocarbon receptor (AhR) is a highly conserved transcription factor that mediates a broad spectrum of species-, strain-, sex-, age-, tissue-, and cell-specific responses elicited by structurally diverse ligands including 2,3,7,8-tetrachlor
Externí odkaz:
https://doaj.org/article/dbd8a85c60a54f1eac7bb719e66ae799