Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping

Autor: Bongiovanni, MN, Godet, J, Horrocks, MH, Tosatto, L, Carr, AR, Wirthensohn, DC, Ranasinghe, RT, Lee, J-E, Ponjavic, A, Fritz, JV, Dobson, CM, Klenerman, D, Lee, SF

Publikováno v: Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Bongiovanni, M N, Godet, J, Horrocks, M H, Tosatto, L, Carr, A R, Wirthensohn, D C, Ranasinghe, R T, Lee, J, Ponjavic, A, Fritz, J V, Dobson, C M, Klenerman, D & Lee, S F 2016, ' Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping ', Nature Communications, vol. 7, 13544 . https://doi.org/10.1038/ncomms13544

Super-resolution microscopy allows biological systems to be studied at the nanoscale, but has been restricted to providing only positional information. Here, we show that it is possible to perform multi-dimensional super-resolution imaging to determi

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http://europepmc.org/articles/PMC5155161

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Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Autor: Xia Z; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK., Prescott EE; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Urbanek A; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Wareing HE; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., King MC; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Olerinyova A; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Dakin H; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK.; Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Leah T; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Barnes KA; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Matuszyk MM; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Dimou E; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK., Hidari E; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK., Zhang YP; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK., Lam JYL; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK., Danial JSH; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK.; SUPA School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, KY16 9SS, UK., Strickland MR; Department of Neurology, Hope Center for Neurological Disorders, Knight ADRC, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Jiang H; Department of Neurology, Hope Center for Neurological Disorders, Knight ADRC, Washington University School of Medicine, St. Louis, MO, USA., Thornton P; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Crowther DC; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ohtonen S; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Gómez-Budia M; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Bell SM; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Ferraiuolo L; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK., Mortiboys H; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.; Healthy Lifespan Institute (HELSI), University of Sheffield, Western Bank, Sheffield, S10 2TN, UK., Higginbottom A; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Wharton SB; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight ADRC, Washington University School of Medicine, St. Louis, MO, USA., Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Ranasinghe RT; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. rr360@cam.ac.uk.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK. rr360@cam.ac.uk., Klenerman D; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. dk10012@cam.ac.uk.; UK Dementia Research Institute at University of Cambridge, Cambridge, UK. dk10012@cam.ac.uk., De S; Sheffield Institute for Translational Neuroscience, Division of Neurosciences, University of Sheffield, Sheffield, S10 2HQ, UK. S.De@sheffield.ac.uk.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK. S.De@sheffield.ac.uk.; Healthy Lifespan Institute (HELSI), University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. S.De@sheffield.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 01; Vol. 15 (1), pp. 4695. Date of Electronic Publication: 2024 Jun 01.

A computational suite for the structural and functional characterization of amyloid aggregates.

Autor: Xia Z; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Wu Y; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Lam JYL; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Zhang Z; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Burke M; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Fertan E; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Ranasinghe RT; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Hidari E; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Danial JSH; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK., Klenerman D; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK.

Publikováno v: Cell reports methods [Cell Rep Methods] 2023 Jun 12; Vol. 3 (6), pp. 100499. Date of Electronic Publication: 2023 Jun 12 (Print Publication: 2023).