Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Ranajeet Ghose"'
Autor:
Fatlum Hajredini, Ranajeet Ghose
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Bacterial tyrosine kinases (BY-kinases) and shikimate kinases (SKs) comprise two structurally divergent P-loop containing enzyme families that share similar catalytic site geometries, most notably with respect to their Walker-A, Walker-B, and DxD mot
Externí odkaz:
https://doaj.org/article/7b3cdc9b6d5c4d8ca9561fdc73d99d90
Autor:
Tamer S. Kaoud, William H. Johnson, Nancy D. Ebelt, Andrea Piserchio, Diana Zamora-Olivares, Sabrina X. Van Ravenstein, Jacey R. Pridgen, Ramakrishna Edupuganti, Rachel Sammons, Micael Cano, Mangalika Warthaka, Matthew Harger, Clint D. J. Tavares, Jihyun Park, Mohamed F. Radwan, Pengyu Ren, Eric V. Anslyn, Kenneth Y. Tsai, Ranajeet Ghose, Kevin N. Dalby
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult to target pharmacologically. Here, the authors identify a small molecule inhibitor that binds covalently to the D-recruitment site of ERK and induces cell de
Externí odkaz:
https://doaj.org/article/a5398760f41b41118e32f8afccdebe49
Autor:
Sunbae Lee, Mangalika Warthaka, Chunli Yan, Tamer S Kaoud, Andrea Piserchio, Ranajeet Ghose, Pengyu Ren, Kevin N Dalby
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18594 (2011)
The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand the mechanisms have been compromised by the lack of MAPK-substrate structures. While MAPK-substrate docking is well establ
Externí odkaz:
https://doaj.org/article/38cd3bd2dc264c7d9c68d717326a4c6c
Autor:
Andrea Piserchio, Kimberly J. Long, Luke S. Browning, Amanda L. Bohanon, Eta A. Isiorho, Kevin N. Dalby, Ranajeet Ghose
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Protein translation, one of the most energy-consumptive processes in a eukaryotic cell, requires robust regulation, especially under energy-deprived conditions. A critical component of this regulation is the suppression of translational elongation th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6c97d4ecc22818d7254b54293a765f2
https://doi.org/10.1073/pnas.2300902120
https://doi.org/10.1073/pnas.2300902120
Autor:
Andrea Piserchio, Eta A. Isiorho, Kimberly Long, Amanda L. Bohanon, Eric A. Kumar, Nathan Will, David Jeruzalmi, Kevin N. Dalby, Ranajeet Ghose
Publikováno v:
Science advances. 8(27)
Translation is a tightly regulated process that ensures optimal protein quality and enables adaptation to energy/nutrient availability. The α-kinase eukaryotic elongation factor 2 kinase (eEF-2K), a key regulator of translation, specifically phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64f53be3172f9f38446b6b46a997e28
https://pubmed.ncbi.nlm.nih.gov/35857468
https://pubmed.ncbi.nlm.nih.gov/35857468
Autor:
Ranajeet Ghose, Fatlum Hajredini
P-loop enzymes, ubiquitous in all of life’s domains and viruses, comprise a monophyletic group with pre-LUCA origins that have differentiated into several three-layered α/β/α− sandwich domain families utilizing a basic β− loop−α−β str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::957d5e93b83571ec579056e1bda390bb
https://doi.org/10.1101/2022.07.13.499785
https://doi.org/10.1101/2022.07.13.499785
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Bacterial tyrosine kinases (BY-kinases) comprise a family of protein tyrosine kinases that are structurally distinct from their functional counterparts in eukaryotes and are highly conserved across the bacterial kingdom. BY-kinases act in concert wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2253dba1a1bd5fc2126f8eb21b4e565
https://doi.org/10.1073/pnas.2201800119
https://doi.org/10.1073/pnas.2201800119
Autor:
Ranajeet Ghose, Kwangwoon Lee, Andrea Piserchio, Eric A. Kumar, Rinat R. Abzalimov, Kevin N. Dalby, Kimberly Long
Publikováno v:
Protein Sci
The calmodulin (CaM) activated α-kinase, eukaryotic elongation factor 2 kinase (eEF-2 K), plays a central role in regulating translational elongation by phosphorylating eukaryotic elongation factor 2 (eEF-2), thereby reducing its ability to associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352b6e8b070cf7720d8c691ec4e9a7c5
https://doi.org/10.1002/pro.4087
https://doi.org/10.1002/pro.4087
Publikováno v:
Journal of Biological Chemistry. :104813
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec6790a84142c1891ec9d2695601f58
https://doi.org/10.1016/j.jbc.2023.104813
https://doi.org/10.1016/j.jbc.2023.104813
Autor:
Andrea Piserchio, Eta A. Isiorho, Kimberly Long, Amanda L. Bohanon, Eric A. Kumar, Nathan Will, David Jeruzalmi, Kevin N. Dalby, Ranajeet Ghose
Translation is a highly energy consumptive process1 tightly regulated for optimal protein quality2 and adaptation to energy and nutrient availability. A key facilitator of this process is the α-kinase eEF-2K that specifically phosphorylates the GTP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b4e67f5d9df2d1be3963b38a053761
https://doi.org/10.1101/2022.01.15.476372
https://doi.org/10.1101/2022.01.15.476372