Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms

Autor: Leming Shi, Yunjie Song, Zhijun Wang, Steven Yeung, Christopher W.K. Lam, Bernard Lau, Jijun Hao, Jeffrey Wang, Mandy Liu, Ranadheer Ravula, Ying Huang, Moses S. S. Chow

Publikováno v: Oncotarget

// Zhijun Wang 1 , Ranadheer Ravula 2 , Leming Shi 3 , Yunjie Song 3 , Steven Yeung 1 , Mandy Liu 2 , Bernard Lau 1 , Jijun Hao 4 , Jeffrey Wang 2 , Christopher Wai Kei Lam 5 , Moses Sing Sum Chow 1 , Ying Huang 2 1 Center for Advancement of Drug Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b120007a66d9395dc70f6319a92afc4
https://doi.org/10.18632/oncotarget.10868

Pharmacogenomic Approach Reveals a Role for the xc−Cystine/Glutamate Antiporter in Growth and Celastrol Resistance of Glioma Cell Lines

Autor: Ying Huang, Omar Alvarado, Anh-Nhan Pham, Paul E. Blower, Ranadheer Ravula, Peter W. Gout

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 332:949-958

The x c − cystine/glutamate antiporter has been implicated in GSH-based chemoresistance because it mediates cellular uptake of cystine/cysteine for sustenance of intracellular GSH levels. Celastrol, isolated from a Chinese medicinal herb, is a nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac3ec772a9872684eac402123983bdf
https://doi.org/10.1124/jpet.109.162248

Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map

Autor: Zhong Zuo, Leming Shi, Ying Huang, Lun Yang, Zhining Wen, Ranadheer Ravula, Moses S. S. Chow, Jun Xu, Steven Wang, Charles Wang, Zhijun Wang

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 3, p e18278 (2011)

To pursue a systematic approach to discovery of mechanisms of action of traditional Chinese medicine (TCM), we used microarrays, bioinformatics and the "Connectivity Map" (CMAP) to examine TCM-induced changes in gene expression. We demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd4093b9bffe5f21dba8cd743a99ac2
https://doi.org/10.1371/journal.pone.0018278

Traditional Chinese medicinal formula Si-Wu-Tang prevents oxidative damage by activating Nrf2-mediated detoxifying/antioxidant genes

Autor: Sunil Prabhu, Bradley T. Andresen, Moses Ss Chow, Ying Huang, Zhijun Wang, Mandy Liu, Ranadheer Ravula, Arvind Thakkar, Zhong Zuo

Publikováno v: Cell & Bioscience

Background Induction of Nrf2-mediated detoxifying/antioxidant genes has been recognized as an effective strategy for cancer chemoprevention. Si-Wu-Tang (SWT), comprising the combination of four herbs, Paeoniae, Angelicae, Chuanxiong and Rehmanniae, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7568afb123d715ac8522e8e72d653267

Overcoming chemoresistance in prostate cancer with Chinese medicine Tripterygium wilfordii via multiple mechanisms.

Autor: Wang Z; Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Ravula R; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Shi L; Center for Pharmacogenomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Schools of Life Sciences and Pharmacy, Fudan University, Shanghai, China., Song Y; Center for Pharmacogenomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Schools of Life Sciences and Pharmacy, Fudan University, Shanghai, China., Yeung S; Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Liu M; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Lau B; Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Hao J; College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA., Wang J; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Lam CW; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau., Chow MS; Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Huang Y; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.

Publikováno v: Oncotarget [Oncotarget] 2016 Sep 20; Vol. 7 (38), pp. 61246-61261.