Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus

Autor: Ranadheer R. Dande, Vasil Peev, Mehmet M. Altintas, Jochen Reiser

Publikováno v: Journal of Diabetes Research, Vol 2017 (2017)

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. DN typically manifests by glomerular hyperfiltration and microalbuminuria; then, the disease progresses to impaired glomerular filtration rate, which leads to

Externí odkaz: https://doaj.org/article/89de15bda40e43608b5b29339e979d5b

Remdesivir in a pregnant patient with COVID-19 pneumonia

Autor: Sajida Zulfiqar, Kia Persaud, Shankar Awasthi, Anum Qureshi, Chahat Puri, Ranadheer R. Dande

Publikováno v: Journal of Community Hospital Internal Medicine Perspectives
article-version (VoR) Version of Record
Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 1, Pp 103-106 (2021)

Remdesivir is an antiviral drug currently being studied as a potential treatment of pneumonia caused by infection with SARS-CoV-2. The Adaptive Covid-19 Treatment Trial (ACTT-1) by NIH and the SIMPLE study by Gilead Sciences are two major trials that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605fabc4419175d2b5eb81ceaaf314f5
http://europepmc.org/articles/PMC7850401

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice

Autor: Zhongji Liao, Ke Zhu, Vasil Peev, Salim S. Hayek, Michael L. Merchant, Shuangxin Liu, Beata Samelko, Nicholas J. Tardi, Jochen Reiser, Stefan Hägele, Jon B. Klein, Brian D. Adair, Jianchao Ma, Sanford J. Shattil, M. Amin Arnaout, Jian Cai, Salvatore DiBartolo, Sanja Sever, Ranadheer R. Dande, Kwi Hye Koh, David Cimbaluk, Jing Li, Melissa Tracy, Changli Wei

Publikováno v: J Clin Invest

Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived circulating signaling molecule that has been implicated in chronic kidney disease, such as focal segmental glomerulosclerosis (FSGS). Typically, native uPAR (isoform 1) tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699b545d832fda89d50d898ad6c77e57
https://doi.org/10.1172/jci124793

TRPC5 Does Not Cause or Aggravate Glomerular Disease

Autor: Xuexiang Wang, Beata Samelko, Mehmet M. Altintas, Rachel E. Miller, Hao Yu, Jochen Reiser, Ranadheer R. Dande

Transient receptor potential channel 5 (TRPC5) is highly expressed in brain and kidney and mediates calcium influx and promotes cell migration. In the kidney, loss of TRPC5 function has been reported to benefit kidney filter dynamics by balancing pod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1048b4df2ee6fa598c5442f3a9db08f
https://europepmc.org/articles/PMC5791075/

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

Autor: Hyun Lee, Lesley A. Inker, Ranadheer R. Dande, Nikolina Stojanović, Garrett Garborcauskas, Beata Samelko, Jochen Reiser, Morgan E. Grams, Jing Li, Changli Wei, Vineet Gupta, Arshed A. Quyyumi, Martin Zeier, Jeffrey B. Kopp, Yi-An Ko, Vasil Peev, Mehmet M. Altintas, Andrew S. Levey, Salim S. Hayek, Sanja Sever, Kwi Hye Koh, Eunsil Hahm, Adrienne Tin, Cheryl A. Winkler, Ha Won Lee, Melissa Tracy, Nicholas J. Tardi, Michael S. Lipkowitz, Karl Skorecki, Josef Coresh, Barry I. Freedman

Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants G1 and G2, but not the reference allele (G0), are associated with an incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8128e9677970ef545043ccbfebe4da58
https://www.bib.irb.hr/887558