Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent

Autor: Mitri K. Khoury, Zhenxia Qin, Dana W. Aswad, Rana N. Khoury, Rachel S. Kaufman

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80758 (2013)
PLoS ONE
Qin, Zhenxia; Kaufman, Rachel S; Khoury, Rana N; Khoury, Mitri K; & Aswad, Dana W. (2013). Isoaspartate Accumulation in Mouse Brain Is Associated with Altered Patterns of Protein Phosphorylation and Acetylation, Some of Which Are Highly Sex-Dependent. PLoS ONE, 8(11), e80758. doi: 10.1371/journal.pone.0080758. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6x63m2vf

Isoaspartate (isoAsp) formation is a major source of protein damage that is kept in check by the repair function of protein L-isoaspartyl methyltransferase (PIMT). Mice deficient in PIMT accumulate isoAsp-containing proteins, resulting in cognitive d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d99e08c0fa3113244bf78823d1d978d
http://europepmc.org/articles/PMC3818261?pdf=render