Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Rana K Gupta"'
Autor:
Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M Gliniak, Lavanya Vishvanath, Yu A An, May-yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K Oz, Ruth Gordillo, Rana K Gupta, Ming Liu, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer
Publikováno v:
eLife, Vol 10 (2021)
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects
Externí odkaz:
https://doaj.org/article/cc9c31e77b504b8e89c7e9bde51878cd
Autor:
Chelsea Hepler, Bo Shan, Qianbin Zhang, Gervaise H Henry, Mengle Shao, Lavanya Vishvanath, Alexandra L Ghaben, Angela B Mobley, Douglas Strand, Gary C Hon, Rana K Gupta
Publikováno v:
eLife, Vol 7 (2018)
White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA-
Externí odkaz:
https://doaj.org/article/57648c7063664e9e832063f3c90b7ec1
Autor:
Chelsea Hepler, Mengle Shao, Jonathan Y Xia, Alexandra L Ghaben, Mackenzie J Pearson, Lavanya Vishvanath, Ankit X Sharma, Thomas S Morley, William L Holland, Rana K Gupta
Publikováno v:
eLife, Vol 6 (2017)
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective. Unlike subcutaneous WAT, visceral WAT is resistant to adopting a pro
Externí odkaz:
https://doaj.org/article/a1deae3e19564b3796959deac5eab293
Autor:
Risheng Ye, William L Holland, Ruth Gordillo, Miao Wang, Qiong A Wang, Mengle Shao, Thomas S Morley, Rana K Gupta, Andreas Stahl, Philipp E Scherer
Publikováno v:
eLife, Vol 3 (2014)
As an adipokine in circulation, adiponectin has been extensively studied for its beneficial metabolic effects. While many important functions have been attributed to adiponectin under high-fat diet conditions, little is known about its essential role
Externí odkaz:
https://doaj.org/article/83bf4796034b481d9eb90f452d20685e
Autor:
Sona Kang, Peter Akerblad, Riku Kiviranta, Rana K Gupta, Shingo Kajimura, Michael J Griffin, Jie Min, Roland Baron, Evan D Rosen
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001433 (2012)
While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It has been recently discovered
Externí odkaz:
https://doaj.org/article/ca5601ca76a24539ada2500c42d7ea13
Autor:
Bo Shan, Clive S. Barker, Harry Theraulaz, Xiaoli Zhang, Yan Ping, Rana K. Gupta, Mengle Shao, Yibo Wu
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102676- (2023)
Summary: Recent studies have revealed cellular heterogeneity of mesenchymal stromal cells and immune cells in adipose tissue and emphasized the need for quantitative analysis of small numbers of functionally distinct cells using state-of-the-art “o
Externí odkaz:
https://doaj.org/article/a3730abcae3b4d8e9b02b51dd61b2d63
Autor:
Camila O. de Souza, Vivian A. Paschoal, Xuenan Sun, Lavanya Vishvanath, Qianbin Zhang, Mengle Shao, Toshiharu Onodera, Shiuhwei Chen, Nolwenn Joffin, Lorena M.A. Bueno, Rana K. Gupta, Da Young Oh
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
The molecular mechanisms underlying obesity-induced increases in β cell mass and the resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92, expressed in islet macrophages, is modulated by dietary interventions in
Externí odkaz:
https://doaj.org/article/fad1f9602d634304975cb07c353a06b4
Publikováno v:
Cell Metabolism. 35:386-413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5103c31923a7892c85def2be7382a7be
https://doi.org/10.1016/j.cmet.2023.02.002
https://doi.org/10.1016/j.cmet.2023.02.002
Autor:
Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang, Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 1-17 (2018)
Objective: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. Methods: Here we have exami
Externí odkaz:
https://doaj.org/article/b2b47e6a4e904925aa53b722a829c482
Publikováno v:
Genes & Development. 35:1333-1338
The full array of cold-responsive cell types within white adipose tissue that drive thermogenic beige adipocyte biogenesis remains undefined. We demonstrate that acute cold challenge elicits striking transcriptomic changes specifically within DPP4+ P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e920d8b18f79ff42fea21abbb8755b3
https://doi.org/10.1101/gad.348762.121
https://doi.org/10.1101/gad.348762.121