Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Rana Gbyli"'
Autor:
Yimeng Gao, Joshua T. Zimmer, Radovan Vasic, Chengyang Liu, Rana Gbyli, Shu-Jian Zheng, Amisha Patel, Wei Liu, Zhihong Qi, Yaping Li, Raman Nelakanti, Yuanbin Song, Giulia Biancon, Andrew Z. Xiao, Sarah Slavoff, Richard G. Kibbey, Richard A. Flavell, Matthew D. Simon, Toma Tebaldi, Hua-Bing Li, Stephanie Halene
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113163- (2023)
Summary: N6-methyladenosine (m6A) RNA modification controls numerous cellular processes. To what extent these post-transcriptional regulatory mechanisms play a role in hematopoiesis has not been fully elucidated. We here show that the m6A demethylase
Externí odkaz:
https://doaj.org/article/18f048077b4b40258f667dc818d9c471
Autor:
Melissa A. Fischer, Yuanbin Song, Maria P. Arrate, Rana Gbyli, Matthew T. Villaume, Brianna N. Smith, Merrida A. Childress, Thomas P. Stricker, Stephanie Halene, Michael R. Savona
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Treatment for myelodysplastic syndromes (MDS) remains insufficient due to clonal heterogeneity and lack of effective clinical therapies. Dysregulation of apoptosis is observed across MDS subtypes regardless of mutations and represents an attractive t
Externí odkaz:
https://doaj.org/article/59613419e2c2473984ff9a5e86775d97
Autor:
Yuanbin Song, Anthony Rongvaux, Ashley Taylor, Tingting Jiang, Toma Tebaldi, Kunthavai Balasubramanian, Arun Bagale, Yunus Kasim Terzi, Rana Gbyli, Xiaman Wang, Xiaoying Fu, Yimeng Gao, Jun Zhao, Nikolai Podoltsev, Mina Xu, Natalia Neparidze, Ellice Wong, Richard Torres, Emanuela M. Bruscia, Yuval Kluger, Markus G. Manz, Richard A. Flavell, Stephanie Halene
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity
Externí odkaz:
https://doaj.org/article/bcd8edb0cae9459b894b2cf494c1bf39
Autor:
Alexander B. Pine, Matthew L. Meizlish, George Goshua, C-Hong Chang, Hanming Zhang, Jason Bishai, Parveen Bahel, Amisha Patel, Rana Gbyli, Jennifer M. Kwan, Christine H. Won, Christina Price, Charles S. Dela Cruz, Stephanie Halene, David van Dijk, John Hwa, Alfred I. Lee, Hyung J. Chun
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Increase in thrombotic and microvascular complications is emerging to be a key feature of patients with critical illness associated with COVID-19 infection. While endotheliopathy is thought to be a key factor of COVID-19-associated coagulopathy, mark
Externí odkaz:
https://doaj.org/article/b63ebb34edc7417bac3ae646450b6612
Autor:
Rana Gbyli, Yuanbin Song, Wei Liu, Yimeng Gao, Giulia Biancon, Namrata S. Chandhok, Xiaman Wang, Xiaoying Fu, Amisha Patel, Ranjini Sundaram, Toma Tebaldi, Padmavathi Mamillapalli, Amer M. Zeidan, Richard A. Flavell, Thomas Prebet, Ranjit S. Bindra, Stephanie Halene
Publikováno v:
Leukemia. 36:1313-1323
Treatment options for patients with relapsed/refractory acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are scarce. Recurring mutations, such as mutations in isocitrate dehydrogenase-1 and -2 (IDH1/2) are found in subsets of AML and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f1f38a604d623f8f5eacc383216360
https://doi.org/10.1038/s41375-022-01536-x
https://doi.org/10.1038/s41375-022-01536-x
Autor:
Till Strowig, Richard A. Flavell, Toma Tebaldi, Jonathan Alderman, Jie Chen, Yuanbin Song, Giulia Biancon, Rana Gbyli, Stephanie Halene, Xiaoying Fu, Yimeng Gao, Mina L. Xu, Diane S. Krause, Liang Shan, Wei Liu, Xiaman Wang, Padmavathi Mamillapalli, Amisha Patel, Elizabeth E. Eynon, Ashley Qin, David Urbonas, Emanuela M. Bruscia, David Gonzalez
Publikováno v:
Science
A red-letter day for RBC research The study of primary human red blood cell (huRBC) disorders such as sickle cell disease (SCD) and infectious diseases such as malaria has been hampered by a lack of in vivo models of human erythropoiesis. Song et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c36851149b99920bc74c7f10c9803f
https://doi.org/10.1126/science.abe2485
https://doi.org/10.1126/science.abe2485
Autor:
Giulia Biancon, Poorval Joshi, Joshua T. Zimmer, Torben Hunck, Yimeng Gao, Mark D. Lessard, Edward Courchaine, Andrew E.S. Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D. Simon, Karla M. Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Mol Cell
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9732eb1548edc00558760338c886ade
https://europepmc.org/articles/PMC8988922/
https://europepmc.org/articles/PMC8988922/
Publikováno v:
Cancer Research. 82:B016-B016
Lung cancer is the leading cause of cancer-related death worldwide and affects over 2 million people each year. In lung adenocarcinoma (LUAD), somatic activating mutations of epidermal growth factor receptor (EGFR) occur in approximately 15% of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033ea9e62da74c474ef270758c2dcf83
https://doi.org/10.1158/1538-7445.cancepi22-b016
https://doi.org/10.1158/1538-7445.cancepi22-b016
Autor:
Toma Tebaldi, Mark D. Lessard, Joshua T. Zimmer, Gabriella Viero, Poorval Joshi, Valentina Botti, Ashley Qin, Karla M. Neugebauer, Giulia Biancon, Torben Hunck, Rana Gbyli, Lea Kiefer, Andrew Es Barentine, Joerg Bewersdorf, Edward M. Courchaine, Yuanbin Song, Matthew D. Simon, Nils Neuenkirchen, Stephanie Halene, Martin Machyna, Haifan Lin, Amisha Patel, Yimeng Gao
Somatic mutations in splicing factors are of significant interest in myeloid malignancies and other cancers. U2AF1, together with U2AF2, is essential for 3’ splice site recognition. U2AF1 mutations result in aberrant splicing, but the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3ecf3e301da6963e53d2e34aaabe26
https://doi.org/10.1101/2021.04.22.441020
https://doi.org/10.1101/2021.04.22.441020
Autor:
Parveen Bahel, Christine Won, Matthew L Meizlish, David van Dijk, Hyung J. Chun, Jennifer M. Kwan, Alexander B Pine, Stephanie Halene, Christina Price, C-Hong Chang, Charles S. Dela Cruz, Alfred Ian Lee, Hanming Zhang, Jason Bishai, Rana Gbyli, Amisha Patel, John Hwa, George Goshua
Publikováno v:
Pulmonary Circulation
medRxiv
Pulmonary Circulation, Vol 10 (2020)
medRxiv
Pulmonary Circulation, Vol 10 (2020)
Increase in thrombotic and microvascular complications is emerging to be a key feature of patients with critical illness associated with COVID-19 infection. While endotheliopathy is thought to be a key factor of COVID-19-associated coagulopathy, mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c3d170b77b837a9acd49f8e410780c
http://europepmc.org/articles/PMC7691906
http://europepmc.org/articles/PMC7691906