Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rana Besada"'
Publikováno v:
Blood Advances, Vol 2, Iss 11, Pp 1229-1242 (2018)
Abstract: Despite the addition of tyrosine kinase inhibitors (TKIs) to the treatment of patients with BCR-ABL1+ B-cell precursor acute lymphoblastic leukemia (BCR-ABL1+ BCP-ALL), relapse both with and without BCR-ABL1 mutations is a persistent clinic
Externí odkaz:
https://doaj.org/article/bcb5f4499d574593aaa787663a0e2a09
Autor:
Yichen Ding, Ayako Shigeta, Matteo Pellegrini, Yan Lu, Haruko Nakano, Tzung K. Hsiai, Vincent Huang, Yasuhiro Nakashima, Bin Zhou, Rajan P. Kulkarni, Jonathan Zuo, Arjun Deb, Atsushi Nakano, Rana Besada
Publikováno v:
Developmental cell, vol 48, iss 5
Summary During mammalian embryogenesis, de novo hematopoiesis occurs transiently in multiple anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered question is whether these local transient hematopoietic mechanisms a
Publikováno v:
Blood advances. 2(11)
Functional in vivo screening reveals distinct genetic dependencies in a mouse model of BCR-ABL1+ BCP-ALL after dasatinib treatment.Disruption of the PAF/PAFR/PAFAH1B axis sensitizes leukemia cells to TKIs; this pathway may be a novel target for combi