Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rana Aldisi"'
Autor:
Sabrina Katrin Henne, Rana Aldisi, Sugirthan Sivalingam, Lara Maleen Hochfeld, Oleg Borisov, Peter Michael Krawitz, Carlo Maj, Markus Maria Nöthen, Stefanie Heilmann-Heimbach
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Male-pattern hair loss (MPHL) is common and highly heritable. While genome-wide association studies (GWAS) have generated insights into the contribution of common variants to MPHL etiology, the relevance of rare variants remains unclear. To
Externí odkaz:
https://doaj.org/article/a171b6aa33ba46fa9e50d5a3280cd103
Autor:
Rana Aldisi, Emadeldin Hassanin, Sugirthan Sivalingam, Andreas Buness, Hannah Klinkhammer, Andreas Mayr, Holger Fröhlich, Peter Krawitz, Carlo Maj
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background A relevant part of the genetic architecture of complex traits is still unknown; despite the discovery of many disease-associated common variants. Polygenic risk score (PRS) models are based on the evaluation of the additive effect
Externí odkaz:
https://doaj.org/article/54759c07922f4167a261203d0f68ded4
Autor:
Emadeldin Hassanin, Isabel Spier, Dheeraj R. Bobbili, Rana Aldisi, Hannah Klinkhammer, Friederike David, Nuria Dueñas, Robert Hüneburg, Claudia Perne, Joan Brunet, Gabriel Capella, Markus M. Nöthen, Andreas J. Forstner, Andreas Mayr, Peter Krawitz, Patrick May, Stefan Aretz, Carlo Maj
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background and aims Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification. Methods To assess the combined impact of the PR
Externí odkaz:
https://doaj.org/article/34b301c2174f410ca6f3edd2fefac30e
Autor:
Emadeldin Hassanin, Ko-Han Lee, Tzung-Chien Hsieh, Rana Aldisi, Yi-Lun Lee, Dheeraj Bobbili, Peter Krawitz, Patrick May, Chien-Yu Chen, Carlo Maj
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Polygenic risk score (PRS) predictions often show bias toward the population of available genome-wide association studies (GWASs), which is typically of European ancestry. This study aimed to assess the performance differences of ancestry-specific PR
Externí odkaz:
https://doaj.org/article/ce508b978b0e472b9477682a7c9895c2
Autor:
Stefanie Heilmann-Heimbach, Peter Krawitz, Markus Nöthen, Oleg Borisov, Carlo Maj, Lara Hochfeld, Sugirthan Sivalingam, Rana Aldisi, Sabrina Henne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb220940a6e2f82cf57d2a3af6832d1
https://doi.org/10.26226/m.62fa009b10629d001aa58d85
https://doi.org/10.26226/m.62fa009b10629d001aa58d85
Autor:
Rana Aldisi, Emadeldin Hassanin, Sugirthan Sivalingam, Andreas Buness, Hannah Klinkhammer, Andreas Mayr, Holger Fröhlich, Peter Krawitz, Carlo Maj
Summary The genetic architecture of complex traits can be influenced by both many common regulatory variants with small effect sizes and rare deleterious variants in coding regions with larger effect sizes. However, the two kinds of genetic contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8892533653abdb1f6e08f5aadbe5b3e8
https://publica.fraunhofer.de/handle/publica/435534
https://publica.fraunhofer.de/handle/publica/435534
Autor:
Andreas J. Forstner, Markus M. Nöthen, Stefan Aretz, Emadeldin Hassanin, Patrick May, Isabel Spier, Rana Aldisi, Peter Krawitz, Carlo Maj, Dheeraj Reddy Bobbili
Publikováno v:
Genetics in medicine 24(3), 576-585 (2022). doi:10.1016/j.gim.2021.11.009
We aimed to investigate to what extent polygenic risk scores (PRS), rare pathogenic germline variants (PVs), and family history jointly influence breast cancer and prostate cancer risk.A total of 200,643 individuals from the UK Biobank were categoriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e080c4471e0b07e504e4ae542a19fc
https://pubmed.ncbi.nlm.nih.gov/34906469
https://pubmed.ncbi.nlm.nih.gov/34906469
Autor:
Lingling Xu, Benjamin M. Gyori, Patrick Greene, Rana Aldisi, John A. Bachman, Martin Hofmann-Apitius, Esther Wollert, Sandra Spalek, Daniel Domingo-Fernández, Charles Tapley Hoyt, Kristian Kolpeja
Publikováno v:
Database: The Journal of Biological Databases and Curation
The rapid accumulation of new biomedical literature not only causes curated knowledge graphs to become outdated and incomplete, but also makes manual curation an impractical and unsustainable solution. Automated or semi-automated workflows are necess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a03144e95c8050f190e2aac31722d5