Výsledky vyhledávání - "Ramzi Melhem"

Akademický článek

Unique profile of ordered arrangements of repetitive elements in the C57BL/6J mouse genome implicating their functional roles.

Autor: Young-Kwan Lee, Kang-Hoon Lee, Seon-Gyu Kim, Ramzi Melhem, Chang-Suk Moon, Sicong Liu, David G Greenhalgh, Kiho Cho

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35156 (2012)

The entirety of all protein coding sequences is reported to represent a small fraction (~2%) of the mouse and human genomes; the vast majority of the rest of the genome is presumed to be repetitive elements (REs). In this study, the C57BL/6J mouse re

Externí odkaz: https://doaj.org/article/bdf38c709847412fa896203a09150cb6

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Akademický článek

Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.

Autor: Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Shuo Wang, Ramzi Melhem, Antonis E Koromilas, Fawaz G Haj

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34412 (2012)

Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress. Herein, we assess the role of PTP1B in ER stress in brown adipocytes, which are k

Externí odkaz: https://doaj.org/article/870265da77d7448ca41eb4e49778d137

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779 A phase I, dose escalation and expansion study of PT199, a next generation CD73 monoclonal antibody, administered alone and in combination with a PD-1 Inhibitor in adult patients with advanced solid tumors

Autor: Ramzi Melhem, Harold Wright, Hui Zou, Claudia Ramos, Jack Li, Ming Wang

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca8f5a2ad75227cacba92fe4c335d29d
https://doi.org/10.1136/jitc-2022-sitc2022.0779

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A phase I, first-in-human, open-label, dose escalation and expansion study of PT886 in adult patients with advanced gastric, gastroesophageal junction, and pancreatic adenocarcinomas

Autor: Michael J. Overman, Ramzi Melhem, Mariela A. Blum-Murphy, Claudia Ramos, Lina Petrosyan, Jack Li, Jessica K Perer, Hui Zou, Ming Wang, Harold M Wright

Publikováno v: Journal of Clinical Oncology. 41:TPS765-TPS765

TPS765 Background: PT886 is a novel bispecific antibody that targets Claudin 18.2 (CLDN18.2) and CD47. CLDN18.2 is overexpressed in a significant proportion of gastric and pancreatic adenocarcinomas and its restricted expression makes it a promising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbb37122a64cdcc966546cd063424dca
https://doi.org/10.1200/jco.2023.41.4_suppl.tps765

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Update on safety and efficacy of a phase 1/2 of SNS-301 added to pembrolizumab in patients with advanced squamous cell carcinoma of the head and neck (SCCHN)

Autor: Lauren Abell, Robert H. Pierce, Jean S. Campbell, Timothy Panella, Dhaval Shah, Ramzi Melhem, Dong M. Shin, William Cairns Stewart Smith, John Celebi, Marie-Louise Fjaellskog, Ann Wild Gramza, Justine Yang Bruce, Alain Algazi

Publikováno v: Journal of Clinical Oncology. 39:6029-6029

6029 Background: The absence of infiltrating antigen-specific CD8+ T-cells at baseline is associated with low response rates to PD-1 blockade. SCCHN tumors often exclude effector T cells, and 2nd line response rates are low (13-18%). Highly immunogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71d3ef4babc3c263c970f0b047d69f16
https://doi.org/10.1200/jco.2021.39.15_suppl.6029

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Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation*

Autor: Ahmed Bettaieb, Peter J. Havel, Daniel AbouBechara, Yannan Xi, James L. Graham, Andrew A. Bremer, Fawaz G. Haj, Zhong Yin Zhang, Lewis C. Cantley, Kosuke Matsuo, Sheng Zhang, Bethany P. Cummings, Kimber L. Stanhope, Jesse Bakke, Ramzi Melhem, Naoto Nagata, Siming Liu, Costas A. Lyssiotis

Publikováno v: The Journal of biological chemistry, vol 288, iss 24
Bettaieb, Ahmed; Bakke, Jesse; Nagata, Naoto; Matsuo, Kosuke; Xi, Yannan; Liu, Siming; et al.(2013). Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation.. The Journal of biological chemistry, 288(24), 17360-17371. doi: 10.1074/jbc.M112.441469. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9kk0r72c

Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and adiposity and is a drug target for the treatment of obesity and diabetes. Here we identify pyruvate kinase M2 (PKM2) as a novel PTP1B substrate in adipocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a0346c387abe235cf1a454e8d76232
https://europepmc.org/articles/PMC3682537/

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Unique profile of ordered arrangements of repetitive elements in the C57BL/6J mouse genome implicating their functional roles

Autor: Seon Gyu Kim, Young Kwan Lee, David G. Greenhalgh, Kiho Cho, Kang Hoon Lee, Chang Suk Moon, Sicong Liu, Ramzi Melhem

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e35156 (2012)
PloS one, vol 7, iss 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59f11b5288ad20e57e2d8dc17893890
https://pubmed.ncbi.nlm.nih.gov/22529984

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