Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ramzi H. Abbassi"'
Autor:
Ariadna Recasens, Sean J. Humphrey, Michael Ellis, Monira Hoque, Ramzi H. Abbassi, Brianna Chen, Mitchell Longworth, Elise J. Needham, David E. James, Terrance G. Johns, Bryan W. Day, Michael Kassiou, Pengyi Yang, Lenka Munoz
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Abstract Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our
Externí odkaz:
https://doaj.org/article/0a8dca1bb09e4683a7fb6162b88375d9
Publikováno v:
International Journal of Cancer. 148:2375-2388
Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene transcription during both development and malignant transformation. Depending
Autor:
Lenka Munoz, Qingqing Zhou, Josep Font, Michael Kassiou, Renae M. Ryan, Ramzi H. Abbassi, Tristan A. Reekie, Dinesh Indurthi Venkata
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:5852-5869
Dual-specificity tyrosine phosphorylation-related kinase 1A (DYRK1A) is a dual-specificity protein kinase that catalyses phosphorylation and autophosphorylation. Higher DYRK1A expression correlates with cancer, in particular glioblastoma present with
Autor:
Bryan W. Day, Sean J. Humphrey, Pengyi Yang, Monira Hoque, Elise J. Needham, Lenka Munoz, Michael Kassiou, Michael J. Ellis, Ariadna Recasens, Brianna Chen, Ramzi H. Abbassi, Mitchell Longworth, David E. James, Terrance Grant Johns
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Cell Death Discovery, Vol 7, Iss 1, Pp 1-16 (2021)
Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphop
Autor:
Michael A. Stashko, Dehui Zhang, Bryan W. Day, Ramzi H. Abbassi, Stephen V. Frye, Lenka Munoz, Xiaodong Wang, Monira Hoque, Siu Wai Wong, Jonathan B. Baell, Nghi Nguyen, Ariadna Recasens
Publikováno v:
Biochemical pharmacology. 186
MerTK has been identified as a promising target for therapeutic intervention in glioblastoma. Genetic studies documented a range of oncogenic processes that MerTK targeting could influence, however robust pharmacological validation has been missing.
Autor:
Ramzi H. Abbassi, Terrance Grant Johns, Ariadna Recasens, Lenka Munoz, Brett W. Stringer, Bryan W. Day, Dinesh C. Indurthi
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Sensitivity to microtubule-targeting agents (MTAs) varies among cancers and predicting the response of individual cancer patients to MTAs remains challenging. As microtubules possess vast molecular heterogeneity generated by tubulin
Autor:
Ramzi H. Abbassi, Michael Kassiou, Jennifer Man, Monira Hoque, Lenka Munoz, Bryan W. Day, Danielle Froio, Terrance Grant Johns, Marina Pajic, Brett W. Stringer
Publikováno v:
Pharmacological research. 134
In the field of kinase inhibitors for applications in cancer research, tubulin is emerging as a targeted cellular protein that can significantly contribute to their activities. However, investigation of kinase inhibitors beyond the kinome is an area
Publikováno v:
Pharmacology & Therapeutics. 151:87-98
Protein kinases are one of the most studied drug targets in current pharmacological research, as evidenced by the vast number of kinase-targeting agents enrolled in active clinical trials. Dual-specificity Tyrosine phosphorylation-Regulated Kinase 1A
Autor:
Lenka Munoz, Mohammed M. Abadleh, Alexander Döbber, Christian Peifer, Athena F Phoa, Brett W. Stringer, Bryan W. Day, Ramzi H. Abbassi, Terrance Grant Johns
Photoremovable protecting groups added to bioactive molecules provide spatial and temporal control of the biological effects. We present synthesis and characterization of the first photoactivatable small-molecule tubulin inhibitor. By blocking the ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92486b7b0b4fc7a23fc9494a3a25fffa
https://europepmc.org/articles/PMC5392771/
https://europepmc.org/articles/PMC5392771/
Autor:
Tristan A. Reekie, Qingqing Zhou, Bryan W. Day, Josep Font, Ramzi H. Abbassi, Terrance Grant Johns, Athena F Phoa, Michael Kassiou, Monira Hoque, Lenka Munoz, Brett W. Stringer, Renae M. Ryan
Publikováno v:
Journal of medicinal chemistry. 60(5)
The DYRK family contains kinases that are up-regulated in malignancy and control several cancer hallmarks. To assess the anticancer potential of inhibitors targeting DYRK kinases, we developed a series of novel DYRK inhibitors based on the 7-azaindol