Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ramzi F, Sweis"'
Autor:
Tim Esbenshade, Martin D. Brand, Ramzi F. Sweis, Simon Melov, Vojtech Mezera, Bryan McKibben, Pratiksha A. Dighe, Marina A. Pliushchev, Akos A. Gerencser, Zhi Wang, Stephan Riedmaier, Hoi Shan Wong
Publikováno v:
Free Radical Biology and Medicine. 164:223-232
Superoxide produced by mitochondria has been implicated in numerous physiologies and pathologies. Eleven different mitochondrial sites that can produce superoxide and/or hydrogen peroxide (O2.-/H2O2) have been identified in vitro, but little is known
Autor:
William N Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Donald J Osterling, Wenqing Gao, Julie K Spence, Marina Pliushchev, Ramzi F Sweis, Fritz G Buchanan, Michael R Michaelides, Alexander R Shoemaker, Chris Tse, Gary G Chiang
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131716 (2015)
Histone methyltransferases are epigenetic regulators that modify key lysine and arginine residues on histones and are believed to play an important role in cancer development and maintenance. These epigenetic modifications are potentially reversible
Externí odkaz:
https://doaj.org/article/22fb11e246334a9a820a7722967d47ee
Autor:
Hoi-Shan, Wong, Vojtech, Mezera, Pratiksha, Dighe, Simon, Melov, Akos A, Gerencser, Ramzi F, Sweis, Marina, Pliushchev, Zhi, Wang, Tim, Esbenshade, Bryan, McKibben, Stephan, Riedmaier, Martin D, Brand
Publikováno v:
Free radical biologymedicine. 164
Superoxide produced by mitochondria has been implicated in numerous physiologies and pathologies. Eleven different mitochondrial sites that can produce superoxide and/or hydrogen peroxide (O
Autor:
Weiguo Liu, Ramzi F. Sweis, Feroze Ujjainwalla, Remond Moningka, F. Anthony Romero, Yi Zang, Paul E. Finke, Zahid Hussain, Karen H. Dingley, Michael A. Plotkin, Andrew D. Howard, Jin Shang, Beth Ann Murphy, Jianming Bao, Gino Salituro, Harold B. Wood, Joseph L. Duffy
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1088-1093
[Image: see text] A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing
Autor:
Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1576-1583
Herein we disclose SAR studies of a series of dimethylamino pyrrolidines which we recently reported as novel inhibitors of the PRC2 complex through disruption of EED/H3K27me3 binding. Modification of the indole and benzyl moieties of screening hit 1
Autor:
Gary G. Chiang, Masoud Vedadi, Alberto Martin, Dalia Barsyte-Lovejoy, William N. Pappano, Cheryl H. Arrowsmith, Alexander Nuber, Vijayaratnam Santhakumar, Kenneth M. Comess, Judd C. Rice, Maricel Torrent, Gunnar Schotta, Peter Brown, Conglei Li, Anup K. Upadhyay, Fengling Li, Alex R Shoemaker, Ramzi F. Sweis, Mikkel Algire, Yujia Dai, Loren M. Lasko, Taylor R H Mitchell, Creighton T. Tuzon, Kenneth D. Bromberg, Mohammad S. Eram, Michael R. Michaelides, Niru B. Soni, Clarissa G. Jakob, Chaohong Sun, Manisha A Jhala, Vlasios Manaves
Publikováno v:
Nature Chemical Biology. 13:317-324
Protein lysine methyltransferases (PKMTs) regulate diverse physiological processes including transcription and the maintenance of genomic integrity. Genetic studies suggest that the PKMTs SUV420H1 and SUV420H2 facilitate proficient nonhomologous end-
Autor:
Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal func
Autor:
John S. Debenham, Dann L. Parker, Birgit T. Priest, Ravi P. Nargund, Feroze Ujjainwalla, Randal M. Bugianesi, Michele Pachanski, Liangqin Guo, William K. Hagmann, George J. Eiermann, Yi Zang, Ramzi F. Sweis, Andrew D. Howard, Jenna L. Terebetski, Melissa Kirkland, Yue Feng, Gino Salituro, Derun Li, Christopher Joseph Sinz, Stan Mitelman, Maria E. Trujillo, Scott D. Edmondson, Karen H. Dingley, Jin Shang, Nicole Buist, Xiaofang Li, Weiguo Liu, Mary Ann Powles, Terri M. Kelly, Edward C. Sherer
GPR142 has been identified as a potential glucose-stimulated insulin secretion (GSIS) target for the treatment of type 2 diabetes mellitus (T2DM). A class of triazole GPR142 agonists was discovered through a high throughput screen. The lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05666abdc0e69d7961b4edf099a12f0b
https://europepmc.org/articles/PMC5150677/
https://europepmc.org/articles/PMC5150677/
Autor:
Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu
Publikováno v:
Nature chemical biology. 13(4)
Polycomb repressive complex 2 (PRC2) is a regulator of epigenetic states required for development and homeostasis. PRC2 trimethylates histone H3 at lysine 27 (H3K27me3), which leads to gene silencing, and is dysregulated in many cancers. The embryoni
Autor:
Carl P. Sparrow, Milton L. Hammond, Denise P. Milot, Peter J. Sinclair, Suzanne S. Eveland, Ramzi F. Sweis, Ying Chen, Samuel D. Wright, Florida Kallashi, Julianne A. Hunt, Qiu Guo, Melanie Latham, Sheryl A. Hyland, Anne-Marie Cumiskey, Ray Rosa, Matt S. Anderson, Larry Peterson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1890-1895
The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the connectivity of