Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma

Autor: Frank Cichocki, Ryan Bjordahl, Jodie P. Goodridge, Sajid Mahmood, Svetlana Gaidarova, Ramzey Abujarour, Zachary B. Davis, Aimee Merino, Katie Tuininga, Hongbo Wang, Akhilesh Kumar, Brian Groff, Alec Witty, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T. Lee, Karl-Johan Malmberg, Bruce Walcheck, Uta Höpken, Armin Rehm, Bahram Valamehr, Jeffrey S. Miller

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

The use of chimeric antigen receptor modified immune cell therapeutics has improved the treatment of a range of tumours. Here the authors explore a dual-target iPSC-derived NK cell product as a potential therapeutic for the treatment of multiple myel

Externí odkaz: https://doaj.org/article/cf51e4650f724761987dbfd84d67e91a

Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

Autor: Sjoukje J. C. van der Stegen, Pieter L. Lindenbergh, Roseanna M. Petrovic, Hongyao Xie, Mame P. Diop, Vera Alexeeva, Yuzhe Shi, Jorge Mansilla-Soto, Mohamad Hamieh, Justin Eyquem, Annalisa Cabriolu, Xiuyan Wang, Ramzey Abujarour, Tom Lee, Raedun Clarke, Bahram Valamehr, Maria Themeli, Isabelle Riviere, Michel Sadelain

Publikováno v: van der Stegen, S J C, Lindenbergh, P L, Petrovic, R M, Xie, H, Diop, M P, Alexeeva, V, Shi, Y, Mansilla-Soto, J, Hamieh, M, Eyquem, J, Cabriolu, A, Wang, X, Abujarour, R, Lee, T, Clarke, R, Valamehr, B, Themeli, M, Riviere, I & Sadelain, M 2022, ' Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells ', Nature Biomedical Engineering, vol. 6, no. 11, pp. 1284-1297 . https://doi.org/10.1038/s41551-022-00915-0
Nature Biomedical Engineering, 6(11), 1284-1297. Nature Publishing Group
Nat Biomed Eng

The production of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-consuming, costly and occasionally unsuccessful. T-cell-derived induced pluripotent stem cells (TiPS) are a promising source for the generation of ‘off-the-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b154e71865ba41f6af9d0b1d675890f
https://doi.org/10.1038/s41551-022-00915-0

Platform for Induction and Maintenance of Transgene-free hiPSCs Resembling Ground State Pluripotent Stem Cells

Autor: Bahram Valamehr, Megan Robinson, Ramzey Abujarour, Betsy Rezner, Florin Vranceanu, Thuy Le, Amanda Medcalf, Tom Tong Lee, Michael Fitch, David Robbins, Peter Flynn

Publikováno v: Stem Cell Reports, Vol 2, Iss 3, Pp 366-381 (2014)

Cell banking, disease modeling, and cell therapy applications have placed increasing demands on hiPSC technology. Specifically, the high-throughput derivation of footprint-free hiPSCs and their expansion in systems that allow scaled production remain

Externí odkaz: https://doaj.org/article/39a79eef3b214c97a19938f5f7df1dcc

Alloimmune Defense Receptor Harnesses Host Immune Cell Activation to Potentiate Functional Persistence and Anti-Tumor Activity of Off-the-Shelf, Cell-Based Cancer Therapy

Autor: Alan M Williams, Ken L Hayama, Yijia Pan, Brian Groff, Rina M Mbofung, Amber Chang, Christine Chen, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Maksim Mamonkin, Raedun Clarke, Ryan Bjordahl, Jode P Goodridge, Bahram Valamehr

Publikováno v: Blood. 140:4547-4548

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e3aa7226880b24c491c1e77b97a462f
https://doi.org/10.1182/blood-2022-167139

Abstract 2828: A novel synthetic stealth receptor that redirects host immune cell alloreactivity and potentiates functional persistence of adoptively transferred off-the-shelf cell-based cancer therapy

Autor: Alan M. Williams, Ken Hayama, Yijia Pan, Brian Groff, Rina Mbofung, Lauren Fong, Nicholas Brookhouser, Berhan Mandefro, Ramzey Abujarour, Tom Lee, Quirin Hammer, Karl-Johan Malmberg, Maksim Mamonkin, Ryan Bjordahl, Jode Goodridge, Bahram Valamehr

Publikováno v: Cancer Research. 82:2828-2828

Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment of hematologic malignancies and have shown significant potential in solid tumor indications. However, logistical complexities associated with patient-specific CAR T-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87f9d53e105e2f4c1b3358e66d62ac47
https://doi.org/10.1158/1538-7445.am2022-2828