Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Ramyavardhanee Chandrasekaran"'
1
Akademický článek
Germinal center activity and B cell maturation are associated with protective antibody responses against Plasmodium pre-erythrocytic infection.
Autor: Ganesh Ram R Visweswaran, Kamalakannan Vijayan, Ramyavardhanee Chandrasekaran, Olesya Trakhimets, Samantha L Brown, Vladimir Vigdorovich, Ashton Yang, Andrew Raappana, Alex Watson, William Selman, Meghan Zuck, Nicholas Dambrauskas, Alexis Kaushansky, D Noah Sather
Publikováno v: PLoS Pathogens, Vol 18, Iss 7, p e1010671 (2022)
Blocking Plasmodium, the causative agent of malaria, at the asymptomatic pre-erythrocytic stage would abrogate disease pathology and prevent transmission. However, the lack of well-defined features within vaccine-elicited antibody responses that corr
Externí odkaz: https://doaj.org/article/d95dfd699a3645d69b9a43f8a7667ee8
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2
Akademický článek
Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis.
Autor: Ramyavardhanee Chandrasekaran, Anne K Kenworthy, D Borden Lacy
Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006070 (2016)
Clostridium difficile infection affects a significant number of hospitalized patients in the United States. Two homologous exotoxins, TcdA and TcdB, are the major virulence factors in C. difficile pathogenesis. The toxins are glucosyltransferases tha
Externí odkaz: https://doaj.org/article/67f1f3ec03564646b03be7b037d92564
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6
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells
Autor: Roman A. Melnyk, Ramyavardhanee Chandrasekaran, D.B. Lacy, Xiaofang Jin, Zhifen Zhang, Godfrey Rainey, Andrew C. Nyborg, Ben Spiller, Heather K. Kroh, Paul Warrener, Kim Rosenthal, Robert M. Woods
Publikováno v: Journal of Biological Chemistry. 293:941-952
Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins perturb host cell function through a multistep process of receptor binding, endocytosis, low pH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf822b7b7856be7d7def3a46ef4e5a71
https://doi.org/10.1074/jbc.m117.813428
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7
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface
Autor: D. Borden Lacy, Heather K. Kroh, Benjamin W. Spiller, Melanie D. Ohi, G. Jonah A. Rainey, Kim Rosenthal, Robert M. Woods, Paul Warrener, Ramyavardhanee Chandrasekaran, Xiaofang Jin, Andrew C. Nyborg
Publikováno v: Journal of Biological Chemistry. 292:14401-14412
Clostridium difficile is a clinically significant pathogen that causes mild-to-severe (and often recurrent) colon infections. Disease symptoms stem from the activities of two large, multidomain toxins known as TcdA and TcdB. The toxins can bind, ente
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42977e095715ba064409a76e43494d03
https://doi.org/10.1074/jbc.m117.781112
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8
Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity
Autor: D. Borden Lacy, Donald H. Rubin, Ramyavardhanee Chandrasekaran, Michelle E. LaFrance, Melissa A. Farrow, Jinsong Sheng
Publikováno v: Proceedings of the National Academy of Sciences. 112:7073-7078
Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflamm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a123eaa8b0d554706200c77e160fb675
https://doi.org/10.1073/pnas.1500791112
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9
The role of toxins in Clostridium difficile infection
Autor: D. Borden Lacy, Ramyavardhanee Chandrasekaran
Clostridium difficile is a bacterial pathogen that is the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. The incidence, severity, mortality and healthcare costs associated with C. difficile infectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03438166cf4e4ba32dd263f32840759b
https://europepmc.org/articles/PMC5812492/
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10
A neutralizing antibody that blocks delivery of the enzymatic cargo of
Autor: Heather K, Kroh, Ramyavardhanee, Chandrasekaran, Zhifen, Zhang, Kim, Rosenthal, Rob, Woods, Xiaofang, Jin, Andrew C, Nyborg, G Jonah, Rainey, Paul, Warrener, Roman A, Melnyk, Benjamin W, Spiller, D Borden, Lacy
Publikováno v: The Journal of biological chemistry. 293(3)
Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins perturb host cell function through a multistep process of receptor binding, endocytosis, low pH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a50d3681ab6ab3c4fe51dff4616a068
https://pubmed.ncbi.nlm.nih.gov/29180448
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