Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ramya Ragupathy"'
Autor:
David G. Alleva, Eline A. Feitsma, Yester F. Janssen, Hendrikus H. Boersma, Thomas M. Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R. Delpero, Melanie M. Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R. Haworth, Nishit J. Shah, Vidhya Rao, Shashikant Nagre, Shannon E. Ronca, Freedom M. Green, Stephen A. Shaw, Ari Aminetzah, Schelto Kruijff, Maarten Brom, Gooitzen M. van Dam, Todd C. Zion
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD), was evaluated without adjuvant in a single cohort, non-randomized, open-labelled phase II stu
Externí odkaz:
https://doaj.org/article/3e169ceb8cc4445682f02ab1847c3f9e
Autor:
David G. Alleva, Andrea R. Delpero, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Thomas M. Lancaster, Mark A. Atkinson, Clive H. Wasserfall, Liping Yu, Ramya Ragupathy, Rachel H. Bonami, Todd C. Zion
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe antigen-presenting cell function of insulin-reactive B cells promotes type 1 diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading to destruction of insulin-producing β-cells of pancreatic islets.M
Externí odkaz:
https://doaj.org/article/b3f0b85106cd4df6a579f9f468414ba7
Autor:
Sean E. Hulsebosch, Jully Pires, Michael J. Bannasch, Thomas Lancaster, Andrea Delpero, Ramya Ragupathy, Sylaja Murikipudi, Todd Zion, Chen Gilor
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 36, Iss 4, Pp 1211-1219 (2022)
Abstract Background For the treatment of diabetes mellitus (DM) in dogs, novel insulins with decreased injection frequency while maintaining safety and efficacy are desirable. Insulin fused with immunoglobulin‐fragment‐crystallizable (Fc) has an
Externí odkaz:
https://doaj.org/article/f7cc2374048c4d978fcee73cebbb3d14
Autor:
Chen Gilor, Sean E. Hulsebosch, Jully Pires, Michael J. Bannasch, Thomas Lancaster, Andrea Delpero, Ramya Ragupathy, Sylaja Murikipudi, Todd Zion
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 35, Iss 5, Pp 2123-2130 (2021)
Abstract Background Treatment of diabetes mellitus (DM) in cats typically requires insulin injections q12h‐q24h, posing a major compliance barrier for caregivers. Novel treatments enabling decreased injection frequency while maintaining safety are
Externí odkaz:
https://doaj.org/article/5997d34775024833b8e2b78436ce3173
Autor:
Andrea R Delpero, Larry Karnes, Shannon E. Ronca, Shashikant Nagre, David G. Alleva, Sarah S Webb, Hanne Andersen Elyard, Allison I Jasa, Thomas M. Lancaster, JoAnn Yee, Sylaja Murikipudi, Vidhya Rao, Frans Sollie, Nishit J Shah, Freedom M Green, Melanie M Scully, Jeffrey R Haworth, Thillainaygam Sathiyaseelan, Emma K Greaves, Ramya Ragupathy, Jeffrey Klein, Todd C. Zion
Publikováno v:
Vaccine
AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutra
Phase I interim results of a phase I/II study of the IgG-Fc fusion COVID-19 subunit vaccine, AKS-452
Autor:
Yester F. Janssen, Eline A. Feitsma, Hendrikus H. Boersma, David G. Alleva, Thomas M. Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R. Delpero, Melanie M. Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R. Haworth, Nishit J. Shah, Vidhya Rao, Shashikant Nagre, Shannon E. Ronca, Freedom M. Green, Ari Aminetzah, Frans Sollie, Schelto Kruijff, Maarten Brom, Gooitzen M. van Dam, Todd C. Zion
Publikováno v:
Vaccine
Vaccine, 40(9), 1253-1260. ELSEVIER SCI LTD
Vaccine, 40(9), 1253-1260. ELSEVIER SCI LTD
To address the coronavirus disease 2019 (COVID-19) pandemic caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recombinant subunit vaccine, AKS-452, is being developed comprising an Fc fusion protein of the SARS-
Autor:
Sean E. Hulsebosch, Jully Pires, Michael J. Bannasch, Thomas Lancaster, Andrea Delpero, Ramya Ragupathy, Sylaja Murikipudi, Todd Zion, Chen Gilor
Publikováno v:
Journal of veterinary internal medicine. 36(4)
For the treatment of diabetes mellitus (DM) in dogs, novel insulins with decreased injection frequency while maintaining safety and efficacy are desirable. Insulin fused with immunoglobulin-fragment-crystallizable (Fc) has an ultra-long plasma half-l