Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ramya Parasuram"'
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0237759 (2020)
DNA repair requires reorganization of the local chromatin structure to facilitate access to and repair of the DNA. Studying DNA double-strand break (DSB) repair in specific chromatin domains has been aided by the use of sequence-specific endonuclease
Externí odkaz:
https://doaj.org/article/39bc6aaad662413c8546054ef5d6e3d8
Autor:
Gene Cooperman, Liang Tian, Joslynn S. Lee, Caitlyn L. Mills, Mary Jo Ondrechen, Alexander I. Suciu, Rohan Garg, Penny J. Beuning, Ramya Parasuram
Publikováno v:
The FASEB Journal. 32
There are currently over 14,300 Structural Genomics (SG) protein structures deposited in the PDB by protein structure initiatives. However, most of these SG proteins have unknown or putative functi...
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 372:20160284
The ability of cells to detect and repair DNA double-strand breaks (DSBs) within the complex architecture of the genome requires co-ordination between the DNA repair machinery and chromatin remodelling complexes. This co-ordination is essential to pr
Publikováno v:
The FASEB Journal. 27
Autor:
Srinivas Somarowthu, Zhouxi Wang, Mary Jo Ondrechen, Pengcheng Yin, Ramya Parasuram, Joslynn S. Lee
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 14, Iss Suppl 3, p S13 (2013)
BMC Bioinformatics, Vol 14, Iss Suppl 3, p S13 (2013)
Background The prediction of biochemical function from the 3D structure of a protein has proved to be much more difficult than was originally foreseen. A reliable method to test the likelihood of putative annotations and to predict function from stru
Effects of non-catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV)
Autor:
Eriks Rozners, Ramya Parasuram, Jason M. Walsh, Penny J. Beuning, Pradyumna R. Rajput, Mary Jo Ondrechen
Publikováno v:
Environmental and molecular mutagenesis. 53(9)
DinB is one of two Y family polymerases in E. coli and is involved in copying damaged DNA. DinB is specialized to bypass deoxyguanosine adducts that occur at the N2 position, with its cognate lesion being the furfuryl adduct. Active site residues hav
Publikováno v:
The FASEB Journal. 26
Publikováno v:
The FASEB Journal. 25
Publikováno v:
Journal of bioinformatics and computational biology. 8
A new approach to the functional classification of protein 3D structures is described with application to some examples from structural genomics. This approach is based on functional site prediction with THEMATICS and POOL. THEMATICS employs calculat