Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ramya Nandakumar"'
Autor:
Thaneas Prabakaran, Anne Troldborg, Sarinya Kumpunya, Isara Alee, Emilija Marinković, Samuel J. Windross, Ramya Nandakumar, Ryo Narita, Bao-cun Zhang, Mikkel Carstensen, Pichpisith Vejvisithsakul, Mikkel H.S. Marqvorsen, Marie B. Iversen, Christian K. Holm, Lars J. Østergaard, Finn Skou Pedersen, Trairak Pisitkun, Rayk Behrendt, Prapaporn Pisitkun, Søren R. Paludan
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103314- (2021)
Background: Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range of diseases are characterized by elevated IFN-I, including systemic lupus erythematosus (lupu
Externí odkaz:
https://doaj.org/article/da5f1e87afd543a2bd603e12507fe509
Autor:
Line S. Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vægter, Jens R. Nyengaard, Katherine A. Fitzgerald, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity
Externí odkaz:
https://doaj.org/article/9c9ff79ecf304100a3671a4551b19557
Autor:
Andrea Kröger, Hansjörg Hauser, Günter Bernhardt, Rainer Zawatzky, Martina Grashoff, Katja Finsterbusch, Ramya Nandakumar, Berit Neumann, Antje Ksienzyk
PDF file - 82K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c61444c0b104c5e1c3d20a22e9313b
https://doi.org/10.1158/0008-5472.22388055.v1
https://doi.org/10.1158/0008-5472.22388055.v1
Autor:
Chiranjeevi Bodda, Søren B. Jensen, Carsten Scavenius, Anne Troldborg, Christine Doucet, Cheng long Sun, Ramya Nandakumar, Anders Laustsen, Thaneas Prabakaran, Zong liang Gao, Samuel J. Windross, Harald Stenmark, Zheng Guo, Line S. Reinert, Sonia Assil, Rune Hartmann, Søren R. Paludan, Jinrong Huang, Martin K. Thomsen, Yan Zhang, Ryo Narita, Jan J. Enghild, Bao cun Zhang, Zhijian J. Chen, Raphaela Goldbach-Mansky, Takeshi Noda, David Olagnier, Rasmus O. Bak, Cong gang Zhang, Martin F. Berthelsen, Yujia Cai
Publikováno v:
Nature immunology
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
Zhang, B C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z L, Sun, C L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology, vol. 21, no. 8, pp. 868-879 . https://doi.org/10.1038/s41590-020-0730-5
Nature Immunology
Nature Immunology, 2020, 21 (8), pp.868-879. ⟨10.1038/s41590-020-0730-5⟩
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0730-5
STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occ
Autor:
Marie B. Iversen, Finn Skou Pedersen, Bao-Cun Zhang, Trairak Pisitkun, Emilija Marinkovic, Christian K. Holm, Anne Troldborg, Ryo Narita, Mikkel H. S. Marqvorsen, Isara Alee, Pichpisith Vejvisithsakul, Mikkel Carstensen, Lars Østergaard, Thaneas Prabakaran, Rayk Behrendt, Samuel J. Windross, Sarinya Kumpunya, Prapaporn Pisitkun, Ramya Nandakumar, Søren R. Paludan
Publikováno v:
EBioMedicine
Prabakaran, T, Troldborg, A, Kumpunya, S, Alee, I, Marinković, E, Windross, S J, Nandakumar, R, Narita, R, Zhang, B-C, Carstensen, M, Vejvisithsakul, P, Marqvorsen, M H S, Iversen, M B, Holm, C K, Østergaard, L J, Pedersen, F S, Pisitkun, T, Behrendt, R, Pisitkun, P & Paludan, S R 2021, ' A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology ', EBioMedicine, vol. 66, 103314 . https://doi.org/10.1016/j.ebiom.2021.103314
EBioMedicine, Vol 66, Iss, Pp 103314-(2021)
Prabakaran, T, Troldborg, A, Kumpunya, S, Alee, I, Marinković, E, Windross, S J, Nandakumar, R, Narita, R, Zhang, B-C, Carstensen, M, Vejvisithsakul, P, Marqvorsen, M H S, Iversen, M B, Holm, C K, Østergaard, L J, Pedersen, F S, Pisitkun, T, Behrendt, R, Pisitkun, P & Paludan, S R 2021, ' A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology ', EBioMedicine, vol. 66, 103314 . https://doi.org/10.1016/j.ebiom.2021.103314
EBioMedicine, Vol 66, Iss, Pp 103314-(2021)
BACKGROUND: Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range of diseases are characterized by elevated IFN-I, including systemic lupus erythematosus (lupu
Autor:
T. Jayalakshmi, N. Manoharan, Ramya Nandakumar, Sudha Ananth, Perumal Santhanam, S Dinesh Kumar, M. Kaviyarasan
Publikováno v:
Journal of the Marine Biological Association of India. 59:25-30
Autor:
Martin F. Berthelsen, Yan Zhang, Ryo Narita, Sonia Assil, Carsten Scavenius, Raphaela Goldbach-Mansky, Rasmus O. Bak, David Olagnier, Zhijian J. Chen, Jinrong Huang, Søren R. Paludan, Takeshi Noda, Samuel J. Windross, Harald Stenmark, Thaneas Prabakaran, Yujia Cai, Rune Hartmann, Line S. Reinert, Zheng Guo, Bao cun Zhang, Martin K. Thomsen, Anders Laustsen, Jan J. Enghild, Ramya Nandakumar, Cheng long Sun, Zong liang Gao, Christine Doucet, Chiranjeevi Bodda, Anne Troldborg, Søren B. Jensen, Cong gang Zhang
Publikováno v:
Zhang, B-C, Nandakumar, R, Reinert, L S, Huang, J, Laustsen, A, Gao, Z-L, Sun, C-L, Jensen, S B, Troldborg, A, Assil, S, Berthelsen, M F, Scavenius, C, Zhang, Y, Windross, S J, Olagnier, D, Prabakaran, T, Bodda, C, Narita, R, Cai, Y, Zhang, C-G, Stenmark, H, Doucet, C M, Noda, T, Guo, Z, Goldbach-Mansky, R, Hartmann, R, Chen, Z J, Enghild, J J, Bak, R O, Thomsen, M K & Paludan, S R 2020, ' Author Correction : STEEP mediates STING ER exit and activation of signaling ', Nature Immunology . https://doi.org/10.1038/s41590-020-0803-5
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Ramya Nandakumar, Søren R. Paludan
Publikováno v:
Journal of Biological Chemistry. 294:16509-16510
Toxoplasma gondii is an obligate protozoan parasite that naturally infects all mammals, where it alters the host environment to establish chronic infection. Wang and colleagues uncover a new role for the T. gondii protein GRA15 in inducing an anti-pa
Publikováno v:
Methods in enzymology. 625
Type I interferons (IFNα/β) are pivotal to anti-viral defense. Although an absolute requirement for viral clearance, the presence of IFN in high doses sustained over time has been implicated to be the underlying cause of clinical outcomes such as i
Autor:
Sonia Assil, Felix Meissner, Roland Tschismarov, Thomas Henry, Kurt V. Gothelf, Tanja Klause, Christian K. Holm, Amandine Martin, Bernd Schmeck, Bao-Cun Zhang, Abhichart Krissanaprasit, Thaneas Prabakaran, Ensieh Farahani, Andrea Ablasser, Thomas Decker, Martin K. Thomsen, Wilhelm Bertrams, Kenneth A. Howard, Søren R. Paludan, Ramya Nandakumar
Publikováno v:
Nandakumar, R, Tschismarov, R, Meissner, F, Prabakaran, T, Krissanaprasit, A, Farahani, E, Zhang, B C, Assil, S, Martin, A, Bertrams, W, Holm, C K, Ablasser, A, Klause, T, Thomsen, M K, Schmeck, B, Howard, K A, Henry, T, Gothelf, K V, Decker, T & Paludan, S R 2019, ' Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling ', Nature Microbiology, vol. 4, pp. 701-713 . https://doi.org/10.1038/s41564-019-0367-z
Nature Microbiology
Nature microbiology
Nature Microbiology
Nature microbiology
The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular Gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b491ad2c2035bb403055d5e813c5c77c
https://pure.au.dk/portal/da/publications/intracellular-bacteria-engage-a-stingtbk1mvb12b-pathway-to-enable-paracrine-cgassting-signalling(5566458b-ad48-483d-883e-537836c4d126).html
https://pure.au.dk/portal/da/publications/intracellular-bacteria-engage-a-stingtbk1mvb12b-pathway-to-enable-paracrine-cgassting-signalling(5566458b-ad48-483d-883e-537836c4d126).html