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Akademický článek

Characterization and comprehensive genome analysis of novel bacteriophage, vB_Kpn_ZCKp20p, with lytic and anti-biofilm potential against clinical multidrug-resistant Klebsiella pneumoniae

Autor: Bishoy Maher Zaki, Nada A. Fahmy, Ramy Karam Aziz, Reham Samir, Ayman El-Shibiny

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

IntroductionThe rise of infections by antibiotic-resistant bacterial pathogens is alarming. Among these, Klebsiella pneumoniae is a leading cause of death by hospital-acquired infections, and its multidrug-resistant strains are flagged as a global th

Externí odkaz: https://doaj.org/article/83e66a867a154be88d23284713bea42a

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Akademický článek

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

Autor: Amal Ahmed Mohamed, Amr Ali Hemeda, Ramy Karam Aziz, Mohamed Salaheldin Abdel-Hakeem, Marwa Ali-Tammam

Publikováno v: Future Journal of Pharmaceutical Sciences, Vol 6, Iss 1, Pp 1-8 (2020)

Abstract Background Viral hepatitis is the seventh leading cause of mortality globally, and half of this mortality is attributed to hepatitis C virus (HCV). Egypt has the highest HCV prevalence worldwide, with an estimated 14.7% of the population bei

Externí odkaz: https://doaj.org/article/50523d727a404559ae51158f034e8431

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Akademický článek

Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics

Autor: Nehal Adel Abdelsalam, Ahmed Tarek Ramadan, Marwa Tarek ElRakaiby, Ramy Karam Aziz

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

The harmful impact of xenobiotics on the environment and human health is being more widely recognized; yet, inter- and intraindividual genetic variations among humans modulate the extent of harm, mostly through modulating the outcome of xenobiotic me

Externí odkaz: https://doaj.org/article/8ea4c295d12342bf89c3332b50527920

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Akademický článek

Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4

Autor: Amr Ali Hemeda, Amal Ahmad Mohamed, Ramy Karam Aziz, Mohamed S. Abdel-Hakeem, Marwa Ali-Tammam

Publikováno v: Viruses, Vol 13, Iss 4, p 714 (2021)

Complications of hepatitis C virus (HCV) chronic infection cause ~400,000 deaths worldwide annually. One complication, liver fibrosis, is influenced by host genetic factors. Genes influencing fibrosis include immune, metabolic, oxidative stress, and

Externí odkaz: https://doaj.org/article/fb6d5a558e6a4029ac353bebe067f66b

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Akademický článek

Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Autor: Ramy Karam Aziz, Valerie eKhaw, Jonathan M Monk, Elizabeth eBrunk, Robert eLewis, Suh In Loh, Arti eMishra, Amrita Abhay Nagle, Chitkala eSatyanarayana, Saravanakumar eDhakshinamoorthy, Michele eLuche, Douglas B Kitchen, Kathleen A Andrews, Bernhard O Palsson, Pep eCharusanti

Publikováno v: Frontiers in Microbiology, Vol 6 (2015)

Mathematical models of biochemical networks form a cornerstone of bacterial systems biology. Inconsistencies between simulation output and experimental data point to gaps in knowledge about the fundamental biology of the organism. One such inconsiste

Externí odkaz: https://doaj.org/article/81d8956d4ca1409f98f98d8c633175ee

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Akademický článek

Multidimensional metrics for estimating phage abundance, distribution, gene density, and sequence coverage in metagenomes

Autor: Ramy Karam Aziz, Bhakti eDwivedi, Sajia eAkhter, Mya eBreitbart, Robert A Edwards

Publikováno v: Frontiers in Microbiology, Vol 6 (2015)

Phages are the most abundant biological entities on Earth and play major ecological roles, yet the current sequenced phage genomes do not adequately represent their diversity, and little is known about the abundance and distribution of these sequence

Externí odkaz: https://doaj.org/article/286da8fbd03e4d2b8bfb53b90dc38164

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