Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ramveer, Choudhary"'
Autor:
Chiara Lucca, Elisa Ferrari, Ghadeer Shubassi, Arta Ajazi, Ramveer Choudhary, Christopher Bruhn, Vittoria Matafora, Angela Bachi, Marco Foiani
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114281- (2024)
Summary: Survival from UV-induced DNA lesions relies on nucleotide excision repair (NER) and the Mec1ATR DNA damage response (DDR). We study DDR and NER in aging cells and find that old cells struggle to repair DNA and activate Mec1ATR. We employ pha
Externí odkaz:
https://doaj.org/article/4d97bca2f57542f98f465facc5dc6eda
Autor:
Ramveer Choudhary, Joanna Niska-Blakie, Mohamood Adhil, Giordano Liberi, Yathish Jagadheesh Achar, Michele Giannattasio, Marco Foiani
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112747- (2023)
Summary: Replication forks terminate at TERs and telomeres. Forks that converge or encounter transcription generate topological stress. Combining genetics, genomics, and transmission electron microscopy, we find that Rrm3hPif1 and Sen1hSenataxin heli
Externí odkaz:
https://doaj.org/article/2dcf6ec0f4454e4289a45fb4b96277f1
Autor:
Divya Purushothaman, Laura F. Bianchi, Dmitry Penkov, Alessandro Poli, Qingsen Li, Jelena Vermezovic, Francesca M. Pramotton, Ramveer Choudhary, Fabrizio A. Pennacchio, Elena Sommariva, Marco Foiani, Nils Gauthier, Paolo Maiuri, Francesco Blasi
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.
Externí odkaz:
https://doaj.org/article/efb52baa31d14c348620b90920ea3ae6
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1010101 (2022)
Glutamine analogs are potent suppressors of general glutamine metabolism with anti-cancer activity. 6-diazo-5-oxo-L-norleucine (DON) is an orally available glutamine analog which has been recently improved by structural modification for cancer treatm
Externí odkaz:
https://doaj.org/article/296f23734628430b860c2dde0b4beb70
Autor:
Christopher Bruhn, Arta Ajazi, Elisa Ferrari, Michael Charles Lanz, Renaud Batrin, Ramveer Choudhary, Adhish Walvekar, Sunil Laxman, Maria Pia Longhese, Emmanuelle Fabre, Marcus Bustamente Smolka, Marco Foiani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose toleran
Externí odkaz:
https://doaj.org/article/c1334c64c88341dd9b8f7f4e9f177694
Autor:
Arun Mouli Kolinjivadi, Siao Ting Chong, Ramveer Choudhary, Haresh Sankar, Ee Ling Chew, Claresta Yeo, Sock Hoai Chan, Joanne Ngeow
Publikováno v:
Human Molecular Genetics. 32:1401-1409
Monoallelic or biallelic RAD51C germline mutations results in chromosome instability disorders such as fanconi anemia (FA) and cancers. The bona fide function of RAD51C is to assist RAD51 nucleoprotein filament onto single strand DNA to complete Homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9839c4262591a414bccfdee6e7bd58de
https://doi.org/10.1093/hmg/ddac281
https://doi.org/10.1093/hmg/ddac281
CNVlocator Author: Mohamood Adhil and Ramveer Choudhary Accurate CNV (Amplification and Deletion) calling by comparing test and control samples (BAM files) Required tools to run the CNV locator: python2.7, R, genomeCoverageBed, samtools Required pyth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512257be9a721b4d56e0ed7bcf8d3ffb
Autor:
Luca Zardoni, Eleonora Nardini, Alessandra Brambati, Chiara Lucca, Ramveer Choudhary, Federica Loperfido, Simone Sabbioneda, Giordano Liberi
Publikováno v:
Nucleic Acids Research
Uncoordinated clashes between replication forks and transcription cause replication stress and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we investigate the outcomes of head-on replication-transcription collisions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef2a6a09d92e4ab8c2c73032267c16c
https://doi.org/10.1093/nar/gkab1146
https://doi.org/10.1093/nar/gkab1146
Autor:
Arun Mouli, Kolinjivadi, Haresh, Sankar, Ramveer, Choudhary, Lavina Sierra, Tay, Tuan Zea, Tan, Naoko, Murata-Kamiya, Dominic Chih-Cheng, Voon, Dennis, Kappei, Masanori, Hatakeyama, Vaidehi, Krishnan, Yoshiaki, Ito
Publikováno v:
International journal of molecular sciences. 23(3)
The proteins from the Fanconi Anemia (FA) pathway of DNA repair maintain DNA replication fork integrity by preventing the unscheduled degradation of nascent DNA at regions of stalled replication forks. Here, we ask if the bacterial pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66ca1e9ada10525036ceb7a12616092d
https://pubmed.ncbi.nlm.nih.gov/35163588
https://pubmed.ncbi.nlm.nih.gov/35163588
Publikováno v:
PLoS genetics. 18(3)
Glutamine analogs are potent suppressors of general glutamine metabolism with anti-cancer activity. 6-diazo-5-oxo-L-norleucine (DON) is an orally available glutamine analog which has been recently improved by structural modification for cancer treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a7e5b1045b693f8ba46779431618b3
https://pubmed.ncbi.nlm.nih.gov/35239666
https://pubmed.ncbi.nlm.nih.gov/35239666