Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ramsey Najm"'
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-13 (2019)
Abstract Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts. Howev
Externí odkaz:
https://doaj.org/article/43efd61014b14d94a23992178f050ebb
Autor:
Ramsey Najm, Kelly A. Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A. Jones, Yadong Huang
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107962- (2020)
Summary: Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to
Externí odkaz:
https://doaj.org/article/f1316fb3a2d5436abc74d71efac9cd01
Autor:
Maxine Nelson, Yadong Huang, Seo Yeon Yoon, Dah-Eun J Amornkul, Kelly A. Zalocusky, Alice An, Antara Rao, Nicole Koutsodendris, Olga Cisne-Thomson, Jason Bant, David A. Bennett, Qin Xu, Yanxia Hao, Ramsey Najm, Alice Taubes
Publikováno v:
Nature neuroscience, vol 24, iss 6
Selective neurodegeneration is a critical causal factor in Alzheimer's disease (AD); however, the mechanisms that lead some neurons to perish, whereas others remain resilient, are unknown. We sought potential drivers of this selective vulnerability u
Publikováno v:
Cell stem cell. 26(3)
Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer's disease (AD) is essential for unravelling its role in pathogenesis. In this issue of Cell Stem Cell, Zheng et al. (2020) report that human tau accumulation in dentate g
Autor:
Seo Yeon Yoon, Yanxia Hao, Yadong Huang, Misha Zilberter, Kelly A. Zalocusky, Antara Rao, Maxine Nelson, Emily Jones, Alice Taubes, Nicole Koutsodendris, Ramsey Najm
Publikováno v:
SSRN Electronic Journal.
Despite its clear impact on Alzheimer’s Disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to model hu
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-13 (2019)
Molecular Neurodegeneration
Molecular Neurodegeneration
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts. However, the u
Autor:
Nicole Koutsodendris, Kelly A. Zalocusky, Yadong Huang, Alice Taubes, Antara Rao, Seo Yeon Yoon, Ramsey Najm, Maxine Nelson, Misha Zilberter, Emily Jones, Yanxia Hao
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107962-(2020)
Cell Rep
Cell Rep
Summary Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in answering this and other questions in AD research has been limited by an inability to
Autor:
Heidi Yuan, Qin Xu, Dah-Eun Jeong, Ramsey Najm, Maureen E. Balestra, Zachary A. Miller, Yadong Huang, Mary J. Malloy, Bruce L. Miller, Gang Li, Chengzhong Wang, David Walker, Seo Yeon Yoon
Publikováno v:
Wang, C; Najm, R; Xu, Q; Jeong, D-E; Walker, D; Balestra, ME; et al.(2018). Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. NATURE MEDICINE, 24(5), 647-+. doi: 10.1038/s41591-018-0004-z. UCSF: Retrieved from: http://www.escholarship.org/uc/item/796161bm
Nature medicine, vol 24, iss 5
Nature medicine
Nature medicine, vol 24, iss 5
Nature medicine
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce54f33017d611954ee58cce37f37b4f
http://www.escholarship.org/uc/item/796161bm
http://www.escholarship.org/uc/item/796161bm
Publikováno v:
Alzheimer's & Dementia. 15:P517-P518