Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Ramsey A. Foty"'
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186483 (2017)
Glioblastoma is highly aggressive. Early dispersal of the primary tumor renders localized therapy ineffective. Recurrence always occurs and leads to patient death. Prior studies have shown that dispersal of Glioblastoma can be significantly reduced b
Externí odkaz:
https://doaj.org/article/c1505cc3e29742a5b54dab2ff8e7b487
Autor:
Caroline C. Friedel, Michael Kluge, Yong Huang, Theodore C Hannah, Guohao Dai, Vivian K. Lee, Igor Katsyv, Ramsey A. Foty, Bin Zhang, Roland H. Friedel, Hongyan Zou, Rut Tejero, Taylor B. Bertucci, Concetta Brusco, Chrystian Junqueira Alves
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Communications Biology
Communications Biology
Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca271f15b6b50b5b7701662db2306c8a
https://doaj.org/article/a21043ef77f3429eb2a9321d811b140e
https://doaj.org/article/a21043ef77f3429eb2a9321d811b140e
Autor:
Stephen Shannon, Connan Vaca, Dongxuan Jia, Ildiko Entersz, Andrew Schaer, Jonathan Carcione, Michael Weaver, Yoav Avidar, Ryan Pettit, Mohan Nair, Atif Khan, Ramsey A Foty
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135951 (2015)
Despite resection and adjuvant therapy, the 5-year survival for patients with Glioblastoma multiforme (GBM) is less than 10%. This poor outcome is largely attributed to rapid tumor growth and early dispersal of cells, factors that contribute to a hig
Externí odkaz:
https://doaj.org/article/1907bec88a3a4667895be0307727e305
Autor:
Miao Yu, David I. Shreiber, Ramsey A. Foty, Jeffrey D. Zahn, Yasir Demiryurek, Jerry W. Shan, Liping Liu, Hao Lin, Seyedsajad Moazzeni
Publikováno v:
Physical review. E. 103(3-1)
The mechanical behavior and cortical tension of single cells are analyzed using electrodeformation relaxation. Four types of cells, namely, MCF-10A, MCF-7, MDA-MB-231, and GBM, are studied, with pulse durations ranging from 0.01 to 10 s. Mechanical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e141d77c3842ad11d21180dfc934ba2
https://pubmed.ncbi.nlm.nih.gov/33862816
https://pubmed.ncbi.nlm.nih.gov/33862816
Autor:
Arthur Carminucci, Ramsey A. Foty, Shabbar F. Danish, Yong Huang, Rut Tejero, Roland H. Friedel
Publikováno v:
Cureus
Identifying drugs that can mitigate dispersal of glioblastoma cells, particularly after patients undergo radiotherapy and concomitant chemotherapy, may increase the length of time to recurrence and improve overall survival. Previous studies have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7746a901da526324d04b98e01b2efa
https://pubmed.ncbi.nlm.nih.gov/32455066
https://pubmed.ncbi.nlm.nih.gov/32455066
Autor:
Paul Beelen, Hao Lin, Jeffrey D. Zahn, Liping Liu, Miao Yu, David I. Shreiber, Yasir Demiryurek, Ramsey A. Foty, Aria Mahtabfar
Publikováno v:
Biophysical Journal. 114:2703-2716
Multicellular aggregates are an excellent model system to explore the role of tissue biomechanics in specifying multicellular reorganization during embryonic developments and malignant invasion. Tissue-like spheroids, when subjected to a compressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6c4e2cf907869cdb2fae16bed9f817
https://doi.org/10.1016/j.bpj.2018.04.025
https://doi.org/10.1016/j.bpj.2018.04.025
Autor:
Joshua Sabari, Daniel Lax, Daniel Connors, Ian Brotman, Eric Mindrebo, Christine Butler, Ildiko Entersz, Dongxuan Jia, Ramsey A Foty
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24810 (2011)
Glioblastoma (GBM), the most aggressive and most common form of primary brain tumor, has a median survival of 12-15 months. Surgical excision, radiation and chemotherapy are rarely curative since tumor cells broadly disperse within the brain. Prevent
Externí odkaz:
https://doaj.org/article/f90785cac8fe45b5880c1073e7546138
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11830 (2010)
Tissue organization during embryonic development and wound healing depends on the ability of cells on the one hand to exchange adhesive bonds during active rearrangement and on the other to become fixed in place as tissue homeostasis is reached. Cell
Externí odkaz:
https://doaj.org/article/24a040f55b8d46789826ae74822a604a
Publikováno v:
Journal of the Mechanics and Physics of Solids. 98:309-329
Measuring mechanical properties of cells or cell aggregates has proven to be an involved process due to their geometrical and structural complexity. Past measurements are based on material models that completely neglect the elasticity of either the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2233c122bf3f194229e5e6e37159623
https://doi.org/10.1016/j.jmps.2016.09.013
https://doi.org/10.1016/j.jmps.2016.09.013
Autor:
Yong Huang, Vivian K. Lee, Ramsey A. Foty, Chrystian Junqueira Alves, Guohao Dai, Roland H. Friedel, Rut Tejero, Hongyan Zou
Publikováno v:
Neuro Oncol
Diffuse invasion of glioblastoma (GBM) cells into brain tissue is a key factor for its high lethality. GBM cell migration is affected by functions of plexins, which are transmembrane receptors of semaphorins that regulate cell adhesion and cytoskelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d149b93670e25a10d3b1e0f8d0118fa
https://europepmc.org/articles/PMC6847662/
https://europepmc.org/articles/PMC6847662/
