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An integrated multi-omics approach identifies the landscape of interferon-alpha-mediated responses of human pancreatic beta cells

Autor: Colli, ML, Ramos-Rodriguez, M, Nakayasu, ES, Alvelos, MI, Lopes, M, Hill, JLE, Turatsinze, JV, de Brachene, AC, Russell, MA, Raurell-Vila, H, Castela, A, Juan-Mateu, J, Webb-Robertson, BJM, Krogvold, L, Dahl-Jorgensen, K, Marselli, L, Marchetti, P, Richardson, SJ, Morgan, NG, Metz, TO, Pasquali, L, Eizirik, DL

Publikováno v: Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Interferon-alpha (IFN alpha), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::08a6134a36824c962a0804088d6471ba
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3359

The impact of proinflammatory cytokines on the beta-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Autor: Ramos-Rodriguez, M, Raurell-Vila, H, Colli, ML, Alvelos, MI, Subirana-Granes, M, Juan-Mateu, J, Norris, R, Turatsinze, JV, Nakayasu, ES, Webb-Robertson, BJM, Inshaw, JRJ, Marchetti, P, Piemonti, L, Esteller, M, Todd, JA, Metz, TO, Eizirik, DL, Pasquali, L

Publikováno v: Nature Genetics
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic beta cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2df3e057d0e7d476f0d478ba62408706
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1342

The impact of pro-inflammatory cytokines on the regulatory landscape of the pancreatic beta cells

Autor: Ramos-Rodriguez, M, Raurell-Vila, H, Juan-Mateu, J, Turatsinze, JV, Eizirik, DL, Pasquali, L

Publikováno v: Diabetologia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::8c9a3317a262667f4da49ef4512e79a8
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6320

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