LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.

Autor: Cobo-Vuilleumier N; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Rodríguez-Fernandez S; Immunology Department, Germans Trias i Pujol Research Institute, Autonomous University of Barcelona, Badalona, Spain., López-Noriega L; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Lorenzo PI; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Franco JM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Lachaud CC; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Vazquez EM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium., Legido RA; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Dorronsoro A; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., López-Férnandez-Sobrino R; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Fernández-Santos B; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Serrano CE; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Salas-Lloret D; Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., van Overbeek N; Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Ramos-Rodriguez M; Pompeu Fabra University, Barcelona, Spain., Mateo-Rodríguez C; Department of Endocrinology and Nutrition, University Hospital Virgen Macarena, Sevilla, Spain., Hidalgo L; Department of Endocrinology and Nutrition, University Hospital Virgen Macarena, Sevilla, Spain., Marin-Canas S; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium., Nano R; Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Arroba AI; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Caro AC; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Vertegaal AC; Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands., Montalvo AM; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain., Martín F; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Aguilar-Diosdado M; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Piemonti L; Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Pasquali L; Pompeu Fabra University, Barcelona, Spain., Prieto RG; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Department of Cell Biology, Faculty of Biology, University of Sevilla, Sevilla, Spain., Sánchez MIG; Biobank of the Andalusian Public Health System, Node Hospital Virgen Macarena, Sevilla, Spain., Eizirik DL; ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), Brussels, Belgium., Martínez-Brocca MA; Department of Endocrinology and Nutrition, University Hospital Puerta del Mar, Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA). University of Cádiz (UCA), Cádiz, Spain., Vives-Pi M; Immunology Department, Germans Trias i Pujol Research Institute, Autonomous University of Barcelona, Badalona, Spain., Gauthier BR; Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.; Nadia Cobo-Vuilleumier and Petra I Lorenzo, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2024 Dec; Vol. 14 (12), pp. e70134.

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The impact of proinflammatory cytokines on the beta-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Autor: Ramos-Rodriguez, M, Raurell-Vila, H, Colli, ML, Alvelos, MI, Subirana-Granes, M, Juan-Mateu, J, Norris, R, Turatsinze, JV, Nakayasu, ES, Webb-Robertson, BJM, Inshaw, JRJ, Marchetti, P, Piemonti, L, Esteller, M, Todd, JA, Metz, TO, Eizirik, DL, Pasquali, L

Publikováno v: Nature Genetics
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic beta cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2df3e057d0e7d476f0d478ba62408706
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1342

An integrated multi-omics approach identifies the type I interferon-induced signature of human beta cells

Autor: Colli, ML, Nakayasu, ES, Ramos-Rodriguez, M, Turatsinze, JV, de Brachene, AC, Lopes, M, dos Santos, RS, Juan-Mateu, J, Raurell-Vila, H, Scharfmann, R, Marchetti, P, Pasquali, L, Metz, TO, Eizirik, DL

Publikováno v: Diabetologia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::567948d225b71f2e24b0f79157b4faf4
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6260

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Autor: Salvadores Rubio, J.J. ^*, Saavedra Miján, J., Ramos Rodríguez, M., Quirós García, J.R.

Publikováno v: In Atencion Primaria 2000 25(1):37-40