Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ramona Steri"'
Autor:
Manfred Schubert-Zsilavecz, Roberto Carrasco Gomez, Daniel Flesch, Holger Stark, Matthias Gabler, Ramona Steri, Andreas Lill, Gisbert Schneider, Daniel Merk
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3490-3498
The ligand activated transcription factor farnesoid X receptor (FXR) is a crucial regulator of several metabolic and inflammatory pathways and its activation by agonistic ligands seems a valuable therapeutic approach for many disorders. Most known no
Autor:
Sascha Weggen, Ramona Steri, Isabella Ogorek, Sven Popella, Oliver Werz, Gerd Dannhardt, Manfred Schubert-Zsilavecz, Julia Ness, Martina Hieke, Friederike Dehm, Daniel Flesch, Christina Lamers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:841-846
We present the design, synthesis and biological evaluation of compounds containing a 2-(benzylidene)hexanoic acid scaffold as multi-target directed γ-secretase-modulators. Broad structural variations were undertaken to elucidate the structure–acti
Autor:
Ramona Steri, Miriam Ude
Publikováno v:
Pharmazie in unserer Zeit. 41:409-415
Eine Schilddrusenfehlfunktion kann negative Auswirkungen auf das ungeborene Kind haben. Fehlgeburten, Fruhgeburten oder Wachstumsretardierungen konnen die Folge sein. Es konnen sowohl Hypo- wie auch Hyperthyreosen auftreten. Wahrend der Schwangerscha
Autor:
Oliver Werz, Sascha Weggen, Martina Hieke, Ramona Steri, Manfred Schubert-Zsilavecz, Heiko Zettl, Christine Greiner, Julia Ness
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5372-5382
A novel set of dual γ-secretase/PPARγ modulators characterized by a 2-benzyl hexanoic acid scaffold is presented. Synthetic efforts were focused on the variation of the substitution pattern of the central benzene. Finally, we obtained a new class o
Autor:
Maren Pellowska, Alexander Paulke, Ralf P. Brandes, Ralph T. Schermuly, Thorsten J. Maier, Anja Mieth, Mario Wurglics, Manfred Schubert-Zsilavecz, Ramona Steri, AS Fischer, Gerd Geisslinger, M Revermann, Dieter Steinhilber, Laura Popescu
Publikováno v:
British Journal of Pharmacology. 163:1721-1732
BACKGROUND AND PURPOSE Arachidonic acid derivatives play a central role in inflammation processes. Arachidonic acid is metabolized by several enzymes, particularly cyclooxygenases (COX), 5-lipoxygenase (5-LOX) and microsomal prostaglandin E-synthase-
Autor:
Sabine Grösch, Gerd Geisslinger, Florian Rörsch, Manfred Schubert-Zsilavecz, Klaus Deckmann, Ramona Steri
Publikováno v:
Biochemical Pharmacology. 80:1365-1372
DMC (dimethylcelecoxib={4-[5-(2,5-dimethylphenyl)-3(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide}) is a close derivative of celecoxib, without cyclooxygenase inhibiting properties up to very high concentrations. Nevertheless, after stimulation
Autor:
Manfred Schubert-Zsilavecz, Ramona Steri, Katja Hansen, Oliver Schwarz, Ewgenij Proschak, Gisbert Schneider, Heiko Zettl, Lutz Müller-Kuhrt, Timon Schroeter, Klaus-Robert Müller, Matthias Rupp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2920-2923
In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor γ, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes in
Autor:
Ramona Steri, Gisbert Schneider, Manfred Schubert-Zsilavecz, Theresa M. Thieme, Ewgenij Proschak, Alexander Paulke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2469-2473
Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved in glucose and lipid homeostasis. PPARgamma agonists are in clinical use for the treatment of type 2 diabetes. Lately, a new class of selective PPARgamma modulators (SPPARgammaM
Publikováno v:
Pharmazie in unserer Zeit. 39:142-146
Die Pharmakotherapie des Diabetes mellitus hat in der letzten Dekade kontinuierlich zugenommen. Die Insulinverordnungen haben sich in diesem Zeitraum verdoppelt. Die Metformin-Verordnungen sind mehr als dreifach angestiegen, wohingegen die der Sulfon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4421-4426
A novel and robust scaffold for highly active PPARalpha agonists based on the 2-mercaptohexanoic acid substructure is presented. Systematic structural variation of the substitution pattern of the phenolic backbone yielded detailed SAR especially of o