Výsledky vyhledávání - "Ramona Stark"

Abstract LB221: Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses

Autor: Isabella Attinger-Toller, Philipp Probst, Romain Bertrand, Emma Renard, Ramona Stark, Roger Santimaria, Dragan Grabulovski, Bernd Schlereth, Philipp Rene Spycher

Publikováno v: Cancer Research. 83:LB221-LB221

The Araris site-specific and one-step peptide linker conjugation technology generates stable, safe and highly potent ADCs without the need for antibody engineering prior to payload conjugation. We generated an anti-Nectin-4 ADC that shows superior an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d22a936be8d16e275ea2066b946ca1a8
https://doi.org/10.1158/1538-7445.am2023-lb221

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Abstract LB219: Inducing significant and efficient tumor growth inhibition vs trastuzumab deruxtecan with low drug-load topoisomerase 1 inhibitor ADC using novel peptide linkers for payload conjugation

Autor: Isabella Attinger-Toller, Rachael Fay, Romain Bertrand, Philipp Probst, Ramona Stark, Roger Santimaria, Dragan Grabulovski, Bernd Schlereth, Philipp Rene Spycher

Publikováno v: Cancer Research. 83:LB219-LB219

The Araris’ site-specific and one-step linker conjugation technology aims at generating stable, safe and highly potent ADCs without the need for antibody engineering prior to payload conjugation. Here, we generated an anti-HER2 ADC using a Topoisom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79a5acd6320576771332e567d7691844
https://doi.org/10.1158/1538-7445.am2023-lb219

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A CD79b Targeting ADC with Superior Anti-Tumor Activity and Safety Resulting in Significantly Improved Therapeutic Index (TI): Safe and Efficacious CD79b ADC

Autor: Bernd Schlereth, Isabella Attinger-toller, Philipp Probst, Romain Bertrand, Ramona Stark, Roger Santimaria, Emma Renard, Rachael Fay, Jeff P. Sharman, Dragan Grabulovski, Philipp Spycher

Publikováno v: Blood. 140:11568-11569

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::324df3f888a6441ed9d901fab1e857bd
https://doi.org/10.1182/blood-2022-160056

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Abstract 2910: A CD79b targeting ADC with superior anti-tumor activity and therapeutic index

Autor: Isabella Attinger-Toller, Philipp Probst, Romain Bertrand, Ramona Stark, Roger Santimaria, Emma Renard, Rachael Fay, Dragan Grabulovski, Bernd Schlereth, Philipp René Spycher

Publikováno v: Cancer Research. 82:2910-2910

The Araris’ site-specific and 1-step linker conjugation technology aims at generating safe and highly potent ADCs without the need for antibody engineering prior to linker-payload conjugation. We developed a very stable anti-CD79b-MMAE ADC with thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5ec27257963a9fc90c70ac7ee75daf2
https://doi.org/10.1158/1538-7445.am2022-2910

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Abstract LB174: Inducing complete and long-lasting tumor eradications at safe and well tolerated doses of a nectin-4 ADC generated with novel peptide linkers for payload conjugation

Autor: Isabella Attinger-Toller, Philipp Probst, Romain Bertrand, Ramona Stark, Roger Santimaria, Dragan Grabulovski, Bernd Schlereth, Philipp Spycher

Publikováno v: Cancer Research. 82:LB174-LB174

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24d7e0a7a4fdef0743ee5d65ef99710e
https://doi.org/10.1158/1538-7445.am2022-lb174

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Abstract 1842: CD79b targeting ADC with superior pharmacokinetic profile and anti-tumor activity

Autor: Philipp R. Spycher, Philipp Probst, Ramona Stark, Dragan Grabulovski, Romain Bertrand, Roger Santimaria, Isabella Attinger-Toller

Publikováno v: Cancer Research. 81:1842-1842

Araris' site-specific conjugation technology is improving the safety and efficacy of ADCs without antibody engineering. Our technology is using transglutaminase for site-specific enzymatic payload conjugation to ‘off-the-shelf' antibodies, i.e., wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb3a33ab6f583d34f86e82768e0d62cc
https://doi.org/10.1158/1538-7445.am2021-1842

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