Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ramona Pais"'
Autor:
Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodo
Externí odkaz:
https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e965989
Autor:
Lawrence J. Billing, Christopher A. Smith, Pierre Larraufie, Deborah A. Goldspink, Sam Galvin, Richard G. Kay, Jonathan D. Howe, Ryan Walker, Mihai Pruna, Leslie Glass, Ramona Pais, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 65-75 (2018)
Objective: Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptideYY (PYY). Unlike GLP-1 and PYY,
Externí odkaz:
https://doaj.org/article/15266b662de9491591e17a5aadc4ad21
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 7 (2016)
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide-1 (GLP-1) are secreted from enteroendocrine cells in the gut and regulate physiological and homeostatic functions related to glucose control, metabolis
Externí odkaz:
https://doaj.org/article/a645cca1ba764a6e8717ad97c17ae50f
Autor:
Fiona M. Gribble, Eleftheria Diakogiannaki, Leslie L Glass, Catherine E. Moss, Carol Lenaghan, Marianne Wedin, Mohammad Bohlooly-Y, David M. Smith, Ramona Pais, Frank Reimann
Publikováno v:
Peptides
Highlights • GPR119, a putative fat sensor, is a potential target for metabolic disease. • KO of GPR119 in murine L-cells reduced GLP-1 response to fat in vivo. • Primary L-cells secreted GLP-1 in response to GPR119 agonists. • GPR119 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2db20a6d3b53ae9ed4b408432d27c5
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G330-G337
Type 2 diabetes is associated with elevated circulating levels of the chemokine RANTES and with decreased plasma levels of the incretin hormone glucagon-like peptide 1 (GLP-1). GLP-1 is a peptide secreted from intestinal L-cells upon nutrient ingesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2b54d2f4a0bdb4b010694f96e54486
https://doi.org/10.1152/ajpgi.00329.2013
https://doi.org/10.1152/ajpgi.00329.2013
Autor:
Frank Reimann, Gwen Tolhurst, Tamara Zietek, Fiona M. Gribble, Helen E. Parker, Hannelore Daniel, Eleftheria Diakogiannaki, Ramona Pais, Beate Rauscher, James A. Horscroft
Publikováno v:
Diabetologia
Aims/hypothesis Ingested protein is a well-recognised stimulus for glucagon-like peptide-1 (GLP-1) release from intestinal L cells. This study aimed to characterise the molecular mechanisms employed by L cells to detect oligopeptides. Methods GLP-1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6aaff85e1da3a585e2c863405c0531
http://europepmc.org/articles/PMC3825574
http://europepmc.org/articles/PMC3825574
Autor:
Britta Spanier, Tamara Stelzl, Judith Kraiczy, Tamara Zietek, Hannelore Daniel, Dominika Kolodziejczak, Kurt Gedrich, Ramona Pais, Christian Scherling
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G897-G907
The intestinal transporter PEPT1 mediates the absorption of di- and tripeptides originating from breakdown of dietary proteins. Whereas mice lacking PEPT1 did not display any obvious changes in phenotype on a high-carbohydrate control diet (HCD), Pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6dab57e4ef52c9cd6b3db40536e214
https://doi.org/10.1152/ajpgi.00160.2012
https://doi.org/10.1152/ajpgi.00160.2012
Publikováno v:
Journal of Biological Chemistry. 288:4513-4521
Although amino acids are dietary nutrients that evoke the secretion of glucagon-like peptide 1 (GLP-1) from intestinal L cells, the precise molecular mechanism(s) by which amino acids regulate GLP-1 secretion from intestinal L cells remains unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff202c70c62c6cf3b0767b5b1f867b7
https://doi.org/10.1074/jbc.m112.402677
https://doi.org/10.1074/jbc.m112.402677
Publikováno v:
Endocrinology
Angiotensin II (Ang II) is the key hormone mediator of the renin angiotensin system, which regulates blood pressure and fluid and electrolyte balance in the body. Here we report that in the colonic epithelium, the Ang II type 1 receptor is highly and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bee2d5d71a316c6a214c9a0144795110
https://pubmed.ncbi.nlm.nih.gov/27447725
https://pubmed.ncbi.nlm.nih.gov/27447725
Autor:
Paul Richards, Fiona M. Gribble, Nikolay B. Milev, Thue W. Schwartz, Frank Reimann, Ramona Pais, Signe M. Jensen, C. Christiansen, Jens J. Holst, Abdella M. Habib, Kristoffer L. Egerod, Berit Svendsen, Maja S. Engelstoft
Publikováno v:
J Endocrinol
The incretin hormones glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from intestinal endocrine cells, the so-called L- and K-cells. The cells are derived from a common precursor and are highly relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a72bcdcd5a31199b9ff8bd6e3c24ddc
https://pubmed.ncbi.nlm.nih.gov/26483393
https://pubmed.ncbi.nlm.nih.gov/26483393