Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ramona Almirez"'
Autor:
Luz Delgado, Roopa Rai, Shailender Chauhan, Patricio Avila, Dhananjay I. Patel, Glenda Fuentealba, Camila Flores, Kevin P. Quinn, T. V. R. Upendra, Vijay Kumar Sharma, Sarvajit Chakravarty, Anjan Kumar Nayak, Emma McCullagh, Gonzalo Ureta, Ramona Almirez, Brahmam Pujala, Sebastian Bernales, Jennifer Alfaro, David T. Hung, Son Minh Pham, Diana Gaete, Sebastian Belmar, Felipe Pérez de Arce, Stacy Kanno, Claudia Acuña, Anup Barde
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:312-321
Although new targeted therapies, such as ibrutinib and idelalisib, have made a large impact on non-Hodgkin's lymphoma (NHL) patients, the disease is often fatal because patients are initially resistant to these targeted therapies, or because they eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88d9ba848c5c5372e62f468a36b17ce
https://doi.org/10.1124/jpet.116.238022
https://doi.org/10.1124/jpet.116.238022
Autor:
Michael J. Green, Roopa Rai, Kevin P. Quinn, Ashu Gupta, Jennifer Alfaro, Dhananjay I. Patel, David T. Hung, Stacy Kanno, Nitin Atmaram Randive, Emma McCullagh, Monali Banerjee, Anamika Thakur, Sarvajit Chakravarty, Anjan Kumar Nayak, Anil Agarwal, Ramona Almirez, Sweta Khare, Brahmam Pujala, Rambabu Guguloth, Sebastian Bernales, Sandip Middya, Mohd. Raja, Son Minh Pham, Bharat Uttam Shinde, Felipe Pérez de Arce, Arjun Surya, Patricio Avila
Publikováno v:
ACS Medicinal Chemistry Letters. 7:1161-1166
The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clinical benefit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36968f9bd3299d938b2fbcd47dfe5c0
https://doi.org/10.1021/acsmedchemlett.6b00356
https://doi.org/10.1021/acsmedchemlett.6b00356
Autor:
Gregory R. Luedtke, Yuanying Anne Huang, Sundeep Dugar, Jose Carlos Chavez, Ramona Almirez, Sarvajit Chakravarty, Cheng Ping Mao, Ann M. Kapoun, Satyanarayana Medicherla, Gladys T. Muiru, Linda S. Higgins, Aaron N. Nguyen, Don Lim, Yu-Wang Liu, Heather K. Webb, Bruce Koppelman, Babu J. Mavunkel, Ying Feng, Andrew A. Protter
Publikováno v:
Pharmacology. 81:204-220
The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ddf888b5b53ad1f684ec45b5167e2d
https://doi.org/10.1159/000112865
https://doi.org/10.1159/000112865
Autor:
Yu Wang Liu, Jörg Wischhusen, Michael Weller, Steffen Aulwurm, Alison Murphy, Markus Weiler, Ramona Almirez, Linda S. Higgins, Jing Ying Ma, Darren H. Wong, Michael Platten, Wolfgang Wick, Martin Uhl, Ruban Mangadu, Ulrich Herrlinger
Publikováno v:
Cancer Research. 64:7954-7961
The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the experimental treatment of human malignant gliomas. Here we characterize the effects of a novel TGF-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d0c36e570d0e9ac4fff96ee6968579
https://doi.org/10.1158/0008-5472.can-04-1013
https://doi.org/10.1158/0008-5472.can-04-1013
Autor:
Jie Hu, John J. Perumattam, Joon Jung, Sundeep Dugar, Jocelyn Tabora, Sarvajit Chakravarty, Imad Nashashibi, Qing Lu, Albert Liclican, Daniel E. Levy, Maureen Laney, Xuefei Tan, Gregory R. Luedtke, Ramona Almirez, Richland Tester, Vinh Tran, Babu J. Mavunkel
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
Derivatives of the 4-fluorobenzyl dimethylpiperazine-indole class of p38alpha MAP kinase inhibitors are described. Biological evaluation of these compounds focused on maintaining activity while improving pharmacokinetic (PK) properties. Improved prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab090924b003a47ad9f1dc0b58b36e5e
https://pubmed.ncbi.nlm.nih.gov/20071169
https://pubmed.ncbi.nlm.nih.gov/20071169
Autor:
Babu J. Mavunkel, George F. Schreiner, Ruban Mangadu, John J. Perumattam, Jing Ying Ma, Sundeep Dugar, Andrew A. Protter, Satyanarayana Medicherla, Mamatha M. Reddy, Irene Kerr, Yu Wang Liu, Fabiola Movius, Tony A. Navas, Gregory R. Luedtke, Bruce Koppelman, Ramona Almirez
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 318(1)
Mitogen-activated protein kinases (MAPKs) and heat shock proteins (HSPs) are ubiquitous proteins that function within T cells in both normal and stress-related pathophysiological states, including type 1 diabetes. The nonobese diabetic (NOD) mouse sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3f067d5eb3f7c50c1a30dba6eec2b8
https://pubmed.ncbi.nlm.nih.gov/16603672
https://pubmed.ncbi.nlm.nih.gov/16603672
Autor:
Irene Kerr, Ruban Mangadu, Jing Ying Ma, Ramona Almirez, Gilbert O'Young, Jenny Zhao, Harry K. Genant, Andrew A. Protter, Ann M. Kapoun, Yebin Jiang, Gregory R. Luedtke, Satyanarayana Medicherla, Elizabeth G. Stebbins, Sarvajit Chakravarty, Sundeep Dugar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 318(1)
Destruction of cartilage and bone is a poorly managed hallmark of human rheumatoid arthritis (RA). p38 Mitogen-activated protein kinase (MAPK) has been shown to regulate key proinflammatory pathways in RA, including tumor necrosis factor alpha, inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7da3110fb5a02c2f9081ae35abaf7a
https://pubmed.ncbi.nlm.nih.gov/16597712
https://pubmed.ncbi.nlm.nih.gov/16597712
Autor:
Sarvajit Chakravarty, Ramona Almirez, David C. Yeomans, Sundeep Dugar, Sarah M. Sweitzer, Satyanarayana Medicherla, Andrew A. Protter, Jennifer A. Shumilla
Publikováno v:
PainReferences. 109(3)
Diabetes can induce a bewildering list of sensory changes, including alteration in pain sensitivity. Painful diabetic neuropathy is refractory to most common analgesics. This study examined the effect of a p38alpha MAPK inhibitor, SD-282, on mechanic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61f3fcc280ab2edd96279b0e2a09f01
https://pubmed.ncbi.nlm.nih.gov/15157702
https://pubmed.ncbi.nlm.nih.gov/15157702
Autor:
Andy Protter, Scott Mills, George F. Schreiner, Faquang Liang, Ann M. Kapoun, Zhihe Li, Maile O’Connell, Ramona Almirez
Publikováno v:
Journal of Cardiac Failure. 10:S43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dca38d924ed1b9d9a87a8d208477d87
https://doi.org/10.1016/j.cardfail.2004.06.087
https://doi.org/10.1016/j.cardfail.2004.06.087
Autor:
Ramona Almirez, Robert Wei
Publikováno v:
Biochemical and Biophysical Research Communications. 62:510-516
A spin-labeled derivative of progesterone was prepared: 3(progesterone-1111α-hemisuccinyl)-3 methylamino-2,2,5,5, tetramethyl pyrolidine-1-oxyl. A corresponding antibody was produced by inoculating rabbits with progesterone-11α-hemisuccinyl-(bovine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77f520a9e0209e24e4cc30b5490dc93
https://doi.org/10.1016/0006-291x(75)90428-3
https://doi.org/10.1016/0006-291x(75)90428-3