Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ramon L. Serrano"'
Autor:
Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, Robert Terkeltaub, Ru Liu-Bryan
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arth
Externí odkaz:
https://doaj.org/article/d6553b490e6f4c16870ac89284cdd33e
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0212235 (2019)
Neointimal hyperplasia, stimulated by injury and certain vascular diseases, promotes artery obstruction and tissue ischemia. In vascular smooth muscle cell (VSMCs), multiple modulators of protein handling machinery regulate intimal hyperplasia. These
Externí odkaz:
https://doaj.org/article/90afe711cdf04353bbb91eb49ab3b111
Publikováno v:
Arthritis & Rheumatology. 70:1030-1041
Objective Osteoarthritis (OA) chondrocytes exhibit impairment of autophagy, one arm of the proteostasis network that coordinates proteome and organelle quality control and degradation. Deficient proteostasis impacts differentiation and viability, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f8637a980547622e4fa17ce83a9e5d
https://doi.org/10.1002/art.40456
https://doi.org/10.1002/art.40456
Publikováno v:
PloS one, vol 14, iss 4
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0212235 (2019)
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0212235 (2019)
Neointimal hyperplasia, stimulated by injury and certain vascular diseases, promotes artery obstruction and tissue ischemia. In vascular smooth muscle cell (VSMCs), multiple modulators of protein handling machinery regulate intimal hyperplasia. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28976bc13debe0951e630b657282be05
https://escholarship.org/uc/item/91t5h4r5
https://escholarship.org/uc/item/91t5h4r5
Autor:
Sushil K. Mahata, Ramon L. Serrano, Ru Liu-Bryan, Charles McWherter, Robert Terkeltaub, Yun-Jung Choi
Publikováno v:
Arthritis research & therapy, vol 20, iss 1
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Background Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis fla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d24cdce91c70444bc6db924ab727bf
https://escholarship.org/uc/item/4mk81919
https://escholarship.org/uc/item/4mk81919
Autor:
Anne N. Murphy, Ricard Garcia-Carbonell, Jeffrey M. Smith, Marta F. Bustamante, Gary S. Firestein, Tatiana Kisseleva, Adam P. Croft, Ramon L. Serrano, Shigeki Miyamoto, Monica Guma, Nissim Hay, Patricia Gnieslaw de Oliveira, Xiao Liu, Christopher D. Buckley, Elsa Sanchez-Lopez
Publikováno v:
Annals of the rheumatic diseases, vol 77, iss 11
ObjectivesRecent studies indicate that glucose metabolism is altered in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). Hexokinases (HKs) catalyse the first step in glucose metabolism, and HK2 constitutes the principal HK inducible isof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b703bc0b5af4739dabfbb691a8a05020
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
The Journal of Cell Biology
The human genome encodes ∼70 Rab GTPases that localize to the surfaces of distinct membrane compartments. To investigate the mechanism of Rab localization, chimeras containing heterologous Rab hypervariable domains were generated, and their ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d188f4444753fcf4a98778f214755c65
https://doi.org/10.1083/jcb.200510010
https://doi.org/10.1083/jcb.200510010
Autor:
Ramon L Serrano, Astrid Hendricks, Irmgard Sinning, J. Bernd Helms, Audrey Kuhn, Matthew Groves
Publikováno v:
Journal of Molecular Biology, 339(1), 173-183. Academic Press
The plant pathogenesis related proteins group 1 (PR-1) and a variety of related mammalian proteins constitute a PR-1 protein family that share sequence and structural similarities. GAPR-1 is a unique family member as thus far it is the only PR-1 fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900708fefb729b25874db67cdd11eb54
https://doi.org/10.1016/j.jmb.2004.03.015
https://doi.org/10.1016/j.jmb.2004.03.015
Publikováno v:
Osteoarthritis and Cartilage. 25:S170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47b88d29e9fa84a4d868f28524763350
https://doi.org/10.1016/j.joca.2017.02.292
https://doi.org/10.1016/j.joca.2017.02.292
Publikováno v:
Atherosclerosis. 233(2)
Bi-allelic function-inactivating ENPP1 mutations cause artery media calcification (AMC) with associated severe myointimal hyperplasia in generalized arterial calcification of infancy (GACI), whereas mono-allelic ENPP1 deficiency is phenotypically nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c92a1c825528c67583f8d81347dd0a
https://pubmed.ncbi.nlm.nih.gov/24530784
https://pubmed.ncbi.nlm.nih.gov/24530784