Výsledky vyhledávání - "Ramon Garcia-Areas"

Suppression of tumor-derived Semaphorin 7A and genetic ablation of host-derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma

Autor: V. Iragavarpu-Charyulu, Maria da Graça Azevedo de Brito, Patricia Keating, Samantha Amat, J. Jaczewska, Kathy Schilling, E. Wojcikiewicz, Stephania Libreros, M. Simoes, Ramon Garcia-Areas, Nathalia Gazaniga, C. Castro-Silva

Publikováno v: International Journal of Oncology

Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c027012c83b0dc85ded602be6ca536
https://doi.org/10.3892/ijo.2017.4144

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Semaphorin7A: branching beyond axonal guidance and into immunity

Autor: Ramon Garcia-Areas, Vijaya Iragavarapu-Charyulu, Stephania Libreros

Publikováno v: Immunologic Research. 57:81-85

Semaphorins are a family of proteins that were originally described for their role in axonal guidance. Studies now show that semaphorins encompass many physiological functions outside of the nervous system, including immune responses. Semaphorin7A (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ff8b832b67d027742bb6475bdeeec7
https://doi.org/10.1007/s12026-013-8460-5

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Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: Decreased tumor metastasis in a breast cancer model

Autor: Ramon Garcia-Areas, Marta Torroella-Kouri, Stephania Libreros, Yoshimi Shibata, Vijaya Iragavarapu-Charyulu, Roberto Carrio

Publikováno v: International Journal of Cancer. 131:377-386

Disseminated metastasis accounts for over 90% of breast cancer deaths. Recently, elevated serum levels of a glycoprotein known as chitinase-3 like-protein-1 (CHI3L1) has been correlated with poor prognosis and shorter survival of patients with metast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6fc306fd1924c317c277697e778782
https://doi.org/10.1002/ijc.26379

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Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1

Autor: Patricia Keating, Nathalia Gazaniga, Stephania Libreros, Alison A. Humbles, Philip Robinson, Vijaya Iragavarapu-Charyulu, Ramon Garcia-Areas

Publikováno v: Journal of leukocyte biology. 97(5)

Metastasis is the primary cause of mortality in women with breast cancer. Metastasis to the lungs is greater in patients with pulmonary inflammatory illnesses. It is unknown how pre-existing pulmonary inflammation affects mammary tumor progression. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da11c2153eafd0378028dc74cc084739
https://pubmed.ncbi.nlm.nih.gov/25765679

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Abstract 5180: Allergic pulmonary inflammation accelerates breast cancer metastasis via increase of MDSCs in the lung microenvironment

Autor: Stephania Libreros, Philip Robinson, Nathalia Gazaniga, Ramon Garcia-Areas, Vijaya Iragavarapu-Charyulu

Publikováno v: Cancer Research. 75:5180-5180

Disseminated metastasis accounts for majority of cancer-related deaths. Lungs are one of the common sites for breast cancer metastasis. Inflammation is known to contribute to tumor initiation and metastasis. Since it is not known the effect of pre-ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::149eea17c5704ff04040ecd17cdec450
https://doi.org/10.1158/1538-7445.am2015-5180

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Abstract 5178: Chitinase-3-like-1 (CHI3L1) expressed during allergic pulmonary inflammation alters lung microenvironment accelerating breast cancer metastasis

Autor: Ramon Garcia-Areas, Nathalia Gazaniga, Stephania Libreros, Camilla S. Castro, Vijaya Iragavarapu-Charyulu

Publikováno v: Cancer Research. 75:5178-5178

Metastasis is the primary cause of mortality in women diagnosed with breast cancer. Metastasis to the lungs is greater in patients with pulmonary inflammatory illnesses, such as asthma. However, it is largely unknown how pulmonary inflammation impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de21a130314f20dd756f5b2eff13fd5c
https://doi.org/10.1158/1538-7445.am2015-5178

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Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

Autor: Patricia Keating, Samantha Amat, Clifford Blieden, Vijaya Iragavarapu-Charyulu, Roberto Carrio, Ramon Garcia-Areas, Stephania Libreros, Philip Robinson

Publikováno v: Frontiers in Physiology
Frontiers in Physiology, Vol 5 (2014)

Semaphorins, a large family of molecules involved in the axonal guidance and development of the nervous system, have been recently shown to have both angiogenic and anti-angiogenic properties. Specifically, semaphorin 7A (SEMA7A) has been reported to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b0b4dd152f788a335a7e93474612c9
https://pubmed.ncbi.nlm.nih.gov/24550834

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Exploring the role of CHI3L1 in 'pre-metastatic' lungs of mammary tumor-bearing mice

Autor: Vijaya Iragavarapu-Charyulu, Ramon Garcia-Areas, Roberto Carrio, Patricia Keating, Stephania Libreros

Publikováno v: Frontiers in Physiology, Vol 4 (2013)
Frontiers in Physiology

Elevated levels of chitinase-3-like-1 (CHI3L1) are associated with poor prognosis, shorter recurrence-free intervals and low survival in breast cancer patients. Breast cancer often metastasizes to the lung. We hypothesized that molecules expressed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ff1895f25fc89a880e30efbc554cb4
https://doi.org/10.3389/fphys.2013.00392

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Abstract 2072: Chitinase-3-like-1 protein expression associated with pulmonary inflammation accelerates metastasis to the lung

Autor: Vijaya Iragavarapu-Charyulu, Stephania Libreros, Ramon Garcia-Areas

Publikováno v: Cancer Research. 74:2072-2072

Disseminated metastasis accounts for majority of breast cancer deaths. Recently, elevated serum levels of a glycoprotein known as chitinase-3-like-1 protein (CHI3L1) has been correlated with poor prognosis and shorter survival of patients with metast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c834e2699c7253ca4bb45a1e510eec9
https://doi.org/10.1158/1538-7445.am2014-2072

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