Synthesis and Anti-Trypanosoma cruzi Activity of 3‑Cyanopyridine Derivatives

Autor: Brian W. Slafer, Marco A. Dessoy, Ramon G. de Oliveira, Maria C. Mollo, Eun Lee, An Matheeussen, Louis Maes, Guy Caljon, Leonardo L. G. Ferreira, Renata Krogh, Adriano D. Andricopulo, Luiza R. Cruz, Charles E. Mowbray, Jadel M. Kratz, Luiz C. Dias

Publikováno v: ACS Omega, Vol 9, Iss 20, Pp 22360-22370 (2024)

Externí odkaz: https://doaj.org/article/181f8460774544aa8d922443939c65c7

A influência da piperina na biodisponibilidade de fármacos: uma abordagem molecular

Autor: Ramon G. de Oliveira, Edilson B. Alencar - Filho, Mário L. A. A. Vasconcellos

Publikováno v: Química Nova, Vol 37, Iss 1, Pp 69-73 (2014)

Piperine is the major alkaloid of Piper nigrum Linn., used as a spice and in folk medicine. We present a molecular docking study supporting experimental data on the enhancement in bioavailability of propranolol, theophylline, phenytoin, nevirapine, n

Externí odkaz: https://doaj.org/article/e122f38c121f4fafaee76798eff22fdd

Evaluation of the antinociceptive and anti-inflammatory activities of piperic acid: Involvement of the cholinergic and vanilloid systems

Autor: Poliana de Araujo Oliveira, Bruno Guimarães Marinho, Wellington da Silva Côrtes, Roberto Laureano-Melo, Thiago Brito de Almeida, Bartolomeu Benedito Neves dos Santos, Ticiana N. França, Joyce Mattos de Oliveira, Gabriela Mastrangelo Gonçalves, Mário L. A. A. Vasconcellos, Ramon G. de Oliveira

Publikováno v: European journal of pharmacology. 834

Piperin is the active compound of black pepper (Piper nigrum). From the piperine was obtained the molecule of the piperic acid (PAC). The objective of this study was to evaluate the antinociceptive and anti-inflammatory of the compound. The antinocic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09234284d09e467307f3c05629436f54
https://pubmed.ncbi.nlm.nih.gov/30009814

Microwave irradiation or low temperature improved synthesis of antiparasitic Morita-Baylis-Hillman adducts

Autor: Fábio P.L. Silva, Claudio G. L. Junior, Natália G. de Andrade, Mário L. A. A. Vasconcellos, Ramon G. de Oliveira, Fernanda Lima Subrinho

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 22, Issue: 11, Pages: 2220-2224, Published: NOV 2011
Journal of the Brazilian Chemical Society v.22 n.11 2011
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

It is reported the synthesis of 24 Morita-Baylis-Hillman adducts (3a-3l/6a-6l) using microwave irradiation at 80 ºC or conventional protocol at 0 ºC to promote the reactions between aromatic aldehydes and methyl acrylate or acrylonitrile (81-99%).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f22dc85420141141cca24f310959d8
https://doi.org/10.1590/s0103-50532011001100028

Microwave-Assisted Convenient Syntheses of 2-Indolizine Derivatives from Morita-Baylis-Hillman Adducts: Newin silicoPotential Ion Channel Modulators

Autor: Ramon G. de Oliveira, Mário L. A. A. Vasconcellos, Saraghina Maria Donato da Cunha

Publikováno v: Journal of the Brazilian Chemical Society.

Neste artigo, um estudo sintetico assistido por irradiacao de micro-ondas para produzir 2-indolizina-carbonitrila e 2-indolizina-carboxilato de metila em bons a altos rendimentos (70 e 81%) em uma etapa a partir de adutos de Morita-Baylis-Hillman (AM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54336014bbf5d1a7b4adec3fdd9b4518
https://doi.org/10.5935/0103-5053.20130056