Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ramon Crehuet"'
Autor:
Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B. Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
Externí odkaz:
https://doaj.org/article/0ea4c921c75c4f04849c5efbc9071b23
Autor:
Claudia Lancey, Muhammad Tehseen, Souvika Bakshi, Matthew Percival, Masateru Takahashi, Mohamed A. Sobhy, Vlad S. Raducanu, Kerry Blair, Frederick W. Muskett, Timothy J. Ragan, Ramon Crehuet, Samir M. Hamdan, Alfredo De Biasio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Translesion Synthesis is a process that enables cells to overcome the deleterious effects of replication stalling caused by DNA lesions. Here the authors present a Cryo-EM structure of human Y-family DNA polymerase k (Pol k) bound to PCNA, P/T DNA an
Externí odkaz:
https://doaj.org/article/fcb4f0fc2e6645adb3f4b1e3da3263f8
Autor:
Nicolai Tidemand Johansen, Marta Bonaccorsi, Tone Bengtsen, Andreas Haahr Larsen, Frederik Grønbæk Tidemand, Martin Cramer Pedersen, Pie Huda, Jens Berndtsson, Tamim Darwish, Nageshewar Rao Yepuri, Anne Martel, Thomas Günther Pomorski, Andrea Bertarello, Mark Sansom, Mikaela Rapp, Ramon Crehuet, Tobias Schubeis, Kresten Lindorff-Larsen, Guido Pintacuda, Lise Arleth
Publikováno v:
eLife, Vol 11 (2022)
The CorA family of proteins regulates the homeostasis of divalent metal ions in many bacteria, archaea, and eukaryotic mitochondria, making it an important target in the investigation of the mechanisms of transport and its functional regulation. Alth
Externí odkaz:
https://doaj.org/article/3958a7b65ed7431d8436567fd3a41ae6
Autor:
Kerry Blair, Muhammad Tehseen, Vlad-Stefan Raducanu, Taha Shahid, Claudia Lancey, Fahad Rashid, Ramon Crehuet, Samir M. Hamdan, Alfredo De Biasio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/8603c279448c4720ab6cad930914fd75
Autor:
Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tra
Externí odkaz:
https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a9
Autor:
Giulio Tesei, João M Martins, Micha B A Kunze, Yong Wang, Ramon Crehuet, Kresten Lindorff-Larsen
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008551 (2021)
Owing to their plasticity, intrinsically disordered and multidomain proteins require descriptions based on multiple conformations, thus calling for techniques and analysis tools that are capable of dealing with conformational ensembles rather than a
Externí odkaz:
https://doaj.org/article/a1aca9ff2a3c4e5db43ce7add8098281
Autor:
Matteo De March, Nekane Merino, Susana Barrera-Vilarmau, Ramon Crehuet, Silvia Onesti, Francisco J. Blanco, Alfredo De Biasio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
DNA sliding clamps are ring-shaped proteins that encircle DNA and harbour polymerases and other factors that promote processive DNA replication. Here the authors use X-ray crystallography, NMR and MD simulations to propose a model for a PCNA sliding
Externí odkaz:
https://doaj.org/article/8c85d2e68cfb4c3dbfb88a6096a853d2
Publikováno v:
Polymers, Vol 13, Iss 2, p 176 (2021)
We study self-association of ubiquitin and the disordered protein ACTR using the most commonly used water models. We find that dissociation events are found only with TIP4P-EW and TIP4P/2005, while the widely used TIP3P water model produces straightf
Externí odkaz:
https://doaj.org/article/410280b8c01e4d6daa5191ba5b6219c8
Publikováno v:
Entropy, Vol 21, Iss 9, p 898 (2019)
Bayesian and Maximum Entropy approaches allow for a statistically sound and systematic fitting of experimental and computational data. Unfortunately, assessing the relative confidence in these two types of data remains difficult as several steps add
Externí odkaz:
https://doaj.org/article/445dbc5a29714bb8b4b6eaa5f9d9e2e8
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 9, p e1002201 (2011)
Oligomerization is a functional requirement for many proteins. The interfacial interactions and the overall packing geometry of the individual monomers are viewed as important determinants of the thermodynamic stability and allosteric regulation of o
Externí odkaz:
https://doaj.org/article/2e738338b3044b51a18c8fa37369688c