Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ramon, Pouplana"'
Autor:
Josep M. Campanera, Ramon Pouplana
Publikováno v:
Molecules, Vol 15, Iss 4, Pp 2730-2748 (2010)
Recent experiments with amyloid-beta (Aβ) peptides indicate that the formation of toxic oligomers may be an important contribution to the onset of Alzheimer’s disease. The toxicity of Aβ oligomers depend on their structure, which is governed by a
Externí odkaz:
https://doaj.org/article/42e45f8fbb054409afb717ecdb8b095a
Autor:
Núria Boixareu, Gloria Rosell, M. Dolors Pujol, Lorena Navarro, Klaus Pors, Silvia Sánchez, Josep M. Campanera, Ramon Pouplana
Publikováno v:
Bioorganicmedicinal chemistry. 26(14)
A novel group of aryl methyl sulfones based on nonsteroidal anti-inflammatory compounds exhibiting a methyl sulfone instead of the acetic or propionic acid group was designed, synthesized and evaluated in vitro for inhibition against the human cycloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601443743d17aa48d8e118ca2308dada
https://pubmed.ncbi.nlm.nih.gov/29980364
https://pubmed.ncbi.nlm.nih.gov/29980364
Publikováno v:
The journal of physical chemistry. B. 120(47)
Amyloid beta (Aβ) oligomerization is associated with the origin and progression of Alzheimer's disease (AD). While the A2V mutation enhances aggregation kinetics and toxicity, mixtures of wild-type (WT) and A2V, and also WT and A2T, peptides retard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b40cf7df03a09542b97840172bd81ba
https://pubmed.ncbi.nlm.nih.gov/27933940
https://pubmed.ncbi.nlm.nih.gov/27933940
Autor:
Giovanni Casula, Salvatore Plescia, Ramon Pouplana, Joan Basset, Y. Harrak, Glòria Rosell, Maria Grazia Cusimano, Demetrio Raffa, Maria Dolors Pujol
Publikováno v:
Journal of Medicinal Chemistry. 53:6560-6571
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These substances were characterized for their capacity to inhibit cyclooxygenase (COX-1 and COX-2) isoenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04705a2aa28acdddd9ac225539b232ed
https://doi.org/10.1021/jm100398z
https://doi.org/10.1021/jm100398z
Autor:
P. Puig-Parellada, Ramon Pouplana, Carmen Pérez, Juan Sebastián Vera Sánchez, Federico Mármol
Publikováno v:
QSAR & Combinatorial Science. 26:368-377
In the present study, we investigated the free radical-scavenging effects of eight Nonsteroidal Anti-Inflammatory Drugs (NSAID) using a Superoxide (O2.−) and Nitric Oxide (.NO) generating system in vitro. Indomethacine showed higher scavenging acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::040562c25b375f6d1037e7d5f6fb362a
https://doi.org/10.1002/qsar.200630067
https://doi.org/10.1002/qsar.200630067
Autor:
J. Ruiz, Ramon Pouplana
Publikováno v:
Quantitative Structure-Activity Relationships. 21:605-612
Due to the importance of the O-H bond dissociation in the antioxidant mechanism of anti-inflammatory phenols, we studied the biradical process Ph-OH → PhO . +H . for 25 phenolic compounds using ah initio calculations. Enthalpies of reaction (ΔH r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6aa0c3becd93a0839391f61c4485092
https://doi.org/10.1002/qsar.200290003
https://doi.org/10.1002/qsar.200290003
Publikováno v:
Journal of Computer-Aided Molecular Design. 16:683-709
The prostaglandin-endoperoxide H synthase-1 (PGHS- 1) and prostaglandin-endoperoxide H synthase-2 (PGHS-2) are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs). It appears that the high degree of selectivity for inhibition of PGHS-2 shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf1c37efb6a57bf602cb34725651d22
https://doi.org/10.1023/a:1022488507391
https://doi.org/10.1023/a:1022488507391
Publikováno v:
The journal of physical chemistry. B. 119(3)
Predicting the conformational preferences of flexible compounds is a challenging problem in drug design, where the recognition between ligand and receptor is affected by the ability of the interacting partners to adopt a favorable conformation for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e435ab61c66ed3327a7c67f1fe4328
https://pubmed.ncbi.nlm.nih.gov/25319869
https://pubmed.ncbi.nlm.nih.gov/25319869
Autor:
Carmen Pérez, P. Puig-Parellada, Juan Sebastián Vera Sánchez, Juan José Lozano, Ramon Pouplana
Publikováno v:
Journal of Computer-Aided Molecular Design. 13:297-313
PGHS-1 and PGHS-2 are the targets of nonsteroidal anti- inflammatory drugs (NSAIDs). It appears that the high degree of selectivity for inhibition of PGHS-2 shown by certain compounds is the result of two mechanisms (time-dependent and time-independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e80c030f3d52d109bb09d6395350cf7
https://doi.org/10.1023/a:1008094616324
https://doi.org/10.1023/a:1008094616324
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 397:59-77
Molecular electrostatic potentials (MEPs) calculated from MNDO wavefunctions were compared with ab initio STO-3G, 3-21G and 6-31G∗∗ values and qualitative agreement was found for diverse classes of nonsteroidal antiinflammatory agents (NSAIDs). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdea520f583f5184f690febaa469b5d
https://doi.org/10.1016/s0166-1280(96)04983-4
https://doi.org/10.1016/s0166-1280(96)04983-4