Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ramon, Mercè"'
Autor:
Xu, Yihan, Dadvand, Payam, Barrera-Gómez, Jose, Sartini, Claudio, Marí-Dell'Olmo, Marc, Borrell, Carme, Medina-Ramón, Mercè, Sunyer, Jordi, Basagaña, Xavier
Publikováno v:
Journal of Epidemiology and Community Health (1979-), 2013 Jun 01. 67(6), 519-525.
Externí odkaz:
https://www.jstor.org/stable/43281565
Autor:
Ermitas Alcalde, Enrique Hernández, Sara López-Pérez, Marta Pujol, Ramon Mercè, Jordi Frigola, Neus Mesquida, Jörg Holenz
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:7387-7397
Further studies in quest of 5-HT(6) serotonin receptor ligands led to the design and synthesis of a few selected examples of N-(inden-5-yl)sulfonamides with a ring-constrained aminoethyl side chain at the indene 3-position, some of which exhibited a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae12d45694feccf0847729966105743
https://doi.org/10.1016/j.bmc.2009.08.006
https://doi.org/10.1016/j.bmc.2009.08.006
Publikováno v:
Journal of Medicinal Chemistry. 52:675-687
Scaffold selection involving an indole-to-indene core change led to the discovery of a series of indenylsulfonamides that act as 5-HT6 serotonin receptor agonists. The variety of the targeted ligands and their synthetic complexity required multistep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d778f4b058f4dcc6090764b0661247e9
https://doi.org/10.1021/jm8009469
https://doi.org/10.1021/jm8009469
Autor:
Ramon Mercè, Jürgen Kraus, Xavier Codony, Jordi-Ramon Quintana-Ruiz, Andrea Aschenbrenner, Stefan Tasler, Oliver Müller, Elena Cubero, Rosalia Pascual, Alberto Dordal, A. Wuzik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6224-6229
Based on a pharmacophore alignment on a 5-HT6 ligand applying 4SCan® technology, a new lead series was identified and further structurally investigated. Kis down to 8 nM were achieved.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c812f24692ba36ea8eca4d2ebbf89466
https://doi.org/10.1016/j.bmcl.2007.09.016
https://doi.org/10.1016/j.bmcl.2007.09.016
Autor:
Ramon Mercè, Raquel Pérez, Javier Burgueño, Sara López-Pérez, Jordi Frigola, Jörg Holenz, Ermitas Alcalde, Neus Mesquida, Immaculada Dinarès
Publikováno v:
Journal of medicinal chemistry. 52(19)
Changing the N,N-(dimethylamino)ethyl side chain in the N-[3-(aminoethyl)inden-5-yl]sulfonamide 5-HT(6) serotonin receptor agonists 1 by a conformationally rigid guanylhydrazone moiety at the indene 3-position led to the identification of the title i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c27c1f66fcc21f69f9a15b64022347
https://pubmed.ncbi.nlm.nih.gov/19739674
https://pubmed.ncbi.nlm.nih.gov/19739674
Autor:
Petrus Johan Pauwels, Xavier Codony, Helmut Buschmann, Jörg Holenz, Jose-Luis Diaz, Ramon Mercè
Publikováno v:
Drug discovery today. 11(7-8)
Although the 5-hydroxytryptamine(6) (5-HT(6)) receptor was discovered only recently, its almost exclusive distribution in the brain makes it a promising, novel, target for central nervous system (CNS)-mediated diseases such as Alzheimer's disease (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5250854c779c1a5a255bbe89cc12526
https://pubmed.ncbi.nlm.nih.gov/16580970
https://pubmed.ncbi.nlm.nih.gov/16580970
Autor:
Gonzalo Romero, Roger Cubí, Xavier Codony, Jose-Luis Diaz, Olga Sanfeliu, Xavier Guitart, Blas Andaluz, Josep Mas, Jörg Holenz, Xavier Monroy, Ramon Mercè, Antoni Torrens, Alberto Dordal, Raquel Pérez, Susana Hernández, Helmut Buschmann, E. N. Sanchez, Enrique Hernández
Publikováno v:
Journal of medicinal chemistry. 48(6)
Based on a medicinal chemistry guided hypothetical pharmacophore model, novel series of indolyl sulfonamides have been designed and prepared as selective and high-affinity serotonin 5-HT(6) receptor ligands. Furthermore, based on a screening approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017fd906a6c893c6197d8cc0620d77f
https://pubmed.ncbi.nlm.nih.gov/15771424
https://pubmed.ncbi.nlm.nih.gov/15771424
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::67403324e65b0fd52a860cfe3578cf53
http://hdl.handle.net/2072/43124
http://hdl.handle.net/2072/43124
Publikováno v:
Organic & Biomolecular Chemistry. 6:3795
A series of novel indene derivatives designed by a scaffold selection gave access to several examples of (Z)-arylmethylideneindenes and indenylsulfonamides that acted as serotonin 5-HT6receptor ligands. Different synthetic multistep routes could be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567baeb50920883802d1c907d136b8ae
https://doi.org/10.1039/b808641a
https://doi.org/10.1039/b808641a
Autor:
Neus Mesquida, Sara López-Pérez, Immaculada Dinarès, Jordi Frigola, Ramon Mercè, Jörg Holenz, Raquel Pérez, Javier Burgueño, Ermitas Alcalde
Publikováno v:
Journal of Medicinal Chemistry; Oct2009, Vol. 52 Issue 19, p6153-6157, 5p