Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Ramon, Colomer"'
Autor:
Ramon Colomer, Jesús Miranda, Nuria Romero-Laorden, Javier Hornedo, Lucía González-Cortijo, Silvana Mouron, Maria J. Bueno, Rebeca Mondéjar, Miguel Quintela-Fandino
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 102029- (2023)
Summary: Background: Next Generation Sequencing (NGS) panels are increasingly used in advanced patients with cancer to guide therapy. There is, however, controversy about when should these panels be used, and about their impact on the clinical course
Externí odkaz:
https://doaj.org/article/a6a92d1fa21047f4a65d551afa0d3bed
Autor:
Silvana Mouron, Luis Manso, Eduardo Caleiras, Jose L. Rodriguez-Peralto, Oscar M. Rueda, Carlos Caldas, Ramon Colomer, Miguel Quintela-Fandino, Maria J. Bueno
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Abstract Background FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their distribution among luminal
Externí odkaz:
https://doaj.org/article/36c3a03ef9334054a049ac7d8445dd69
Autor:
Miguel Quintela-Fandino, Esther Holgado, Luis Manso, Serafin Morales, Begoña Bermejo, Ramon Colomer, Juan V. Apala, Raquel Blanco, Manuel Muñoz, Eduardo Caleiras, Vega Iranzo, Mario Martinez, Orlando Dominguez, Javier Hornedo, Lucia Gonzalez-Cortijo, Javier Cortes, Ariadna Gasol Cudos, Diego Malon, Antonio Lopez-Alonso, María C. Moreno-Ortíz, Silvana Mouron, Santos Mañes
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background Preclinical research suggests that the efficacy of immune checkpoint inhibitors in breast cancer can be enhanced by combining them with antiangiogenics, particularly in a sequential fashion. We sought to explore the efficacy and b
Externí odkaz:
https://doaj.org/article/3f6add655fbe4b0d92de37dd9a97fca3
Autor:
Patricia Toquero, Carmen Blanco Fernández, María Pilar López Martí, Berta Hernández Marín, E. Beatriz Vera Cea, Ana Garrido García, Elena Méndez Carrascosa, Dulce Bañón Torres, Olga Donnay Candil, Ana Isabel Ballesteros García, José Miguel Sánchez-Torres, Pablo Costas Rojo, Rebeca Mondéjar, Ramon Colomer, Nuria Romero-Laorden
Publikováno v:
Frontiers in Psychology, Vol 12 (2021)
Background: The COVID-19 pandemic has caused mental health problems worldwide. The psychopathological implications of COVID-19 in cancer patients have rarely been addressed. Considering the increased vulnerability of oncology patients, this issue nee
Externí odkaz:
https://doaj.org/article/b8329cf138ef4bac874cbb320737c842
Autor:
Maria J. Bueno, Veronica Jimenez-Renard, Sara Samino, Jordi Capellades, Alejandra Junza, María Luz López-Rodríguez, Javier Garcia-Carceles, Irene Lopez-Fabuel, Juan P. Bolaños, Navdeep S. Chandel, Oscar Yanes, Ramon Colomer, Miguel Quintela-Fandino
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its inhi
Externí odkaz:
https://doaj.org/article/b89dd0324e784e3382a7385377353baf
Autor:
Miguel Quintela-Fandino, Juan V. Apala, Diego Malon, Silvana Mouron, Javier Hornedo, Lucia Gonzalez-Cortijo, Ramon Colomer, Juan Guerra
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background The combined use of a FGFR1 blocker and aromatase inhibitors is appealing for treating breast cancer patients with FGFR1 amplification. However, no pharmacodynamic studies have addressed the effects of this combined target modulat
Externí odkaz:
https://doaj.org/article/1917c626fbb948caba36756bcb86cc27
Autor:
Santiago Sánchez-Alonso, Giulia Setti-Jerez, Montserrat Arroyo, Tathiana Hernández, Mª Inmaculada Martos, Jose Miguel Sánchez-Torres, Ramon Colomer, Almudena R Ramiro, Arantzazu Alfranca
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Lung cancer is one of the most frequent malignancies in humans and is a major cause of death. A number of therapies aimed at reinforcing antitumor immune response, including antiprogrammed cell death protein 1 (anti-PD-1) antibodies, are s
Externí odkaz:
https://doaj.org/article/497600bd67f246cc9b6518d283ef1142
Autor:
Ramon Colomer, Rebeca Mondejar, Nuria Romero-Laorden, Arantzazu Alfranca, Francisco Sanchez-Madrid, Miguel Quintela-Fandino
Publikováno v:
EClinicalMedicine, Vol 25, Iss , Pp 100487- (2020)
Technical advances in genome sequencing and the implementation of next-generation sequencing (NGS) in clinical oncology have paved the way for individualizing cancer patient therapy based on molecular profiles. When and how to use NGS testing in the
Externí odkaz:
https://doaj.org/article/e1f26395b6474bfa9841102a9061406a
Autor:
Jacobo Rogado, Nuria Romero-Laorden, José Miguel Sanchez-Torres, Ana María Ramos-Levi, Vilma Pacheco-Barcia, Ana Isabel Ballesteros, Reyes Arranz, Alicia Lorenzo, Pedro Gullon, Ana Garrido, José María Serra López-Matencio, Olga Donnay, Magdalena Adrados, Pablo Costas, Javier Aspa, Arantzazu Alfranca, Rebeca Mondejar, Ramon Colomer
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immunotherapy is an effective treatment in advanced cancer, although predictors of response are limited. We studied whether excess weight influences the efficacy outcomes of immunotherapy. We have also evaluated the combined prognostic effect of exce
Externí odkaz:
https://doaj.org/article/c17e72bb7ac94c3c8391d210e75236de
Autor:
Ivana Zagorac, Sara Fernandez-Gaitero, Renske Penning, Harm Post, Maria J. Bueno, Silvana Mouron, Luis Manso, Manuel M. Morente, Soledad Alonso, Violeta Serra, Javier Muñoz, Gonzalo Gómez-López, Jose Francisco Lopez-Acosta, Veronica Jimenez-Renard, Albert Gris-Oliver, Fatima Al-Shahrour, Elena Piñeiro-Yañez, Jose Luis Montoya-Suarez, Juan V. Apala, Amalia Moreno-Torres, Ramon Colomer, Ana Dopazo, Albert J. R. Heck, Maarten Altelaar, Miguel Quintela-Fandino
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, the authors use phosphoproteomics to define kinases with distinct activity profiles in TNBC, demonstrating their prognostic value as well as their utility for simplif
Externí odkaz:
https://doaj.org/article/6508e17c6fdd4f1a8cecab535185385a