Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rammohan R. Yadav Bheemanaboina"'
Publikováno v:
Bioorganic chemistry. 127
Aloe emodin-conjugated sulfonyl hydrazones were designed and synthesized as novel type of antibacterial modulators. Aloe emodin benzenesulfonyl hydrazone 5a (AEBH-5a) was preponderant for the treatment of S. aureus 25923 (MIC = 0.5 μg/mL) over norfl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e886f4c8a1c8cf8061768e9a69a9c2
https://pubmed.ncbi.nlm.nih.gov/35870413
https://pubmed.ncbi.nlm.nih.gov/35870413
Autor:
Tyler Eck, Mariana Laureano de Souza, Melvin Delvillar, Kutub Ashraf, Rammohan R. Yadav Bheemanaboina, Ramappa Chakrasali, Tamara Kreiss, John J. Siekierka, David P. Rotella, Purnima Bhanot, Nina M. Goodey
Publikováno v:
Chembiochem
P. falciparum cGMP-dependent protein kinase (PfPKG) is an enticing anti-malarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole-based comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cbf8dfbddf28ef59a5017fb94c15ac
https://pubmed.ncbi.nlm.nih.gov/35044710
https://pubmed.ncbi.nlm.nih.gov/35044710
Autor:
Tyler Eck, John Gordon, Wayne E. Childers, Brandon S. Pybus, Dennis J. Colussi, Tamara Kreiss, Alison Roth, Rammohan R. Yadav Bheemanaboina, David P. Rotella, Shams Ul Mahmood, Patricia J. Lee, Purnima Bhanot, Samantha O. Aylor, Mariana Laureano de Souza, Mariana Lozano Gonzalez, John J. Siekierka
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8fe3378b6bb8e06313fdebf1e4dbd7
https://europepmc.org/articles/PMC8667308/
https://europepmc.org/articles/PMC8667308/
Autor:
Purnima Bhanot, Mariana Lozano Gonzalez, Brandon S. Pybus, John Gordon, Wayne E. Childers, David P. Rotella, Rammohan R. Yadav Bheemanaboina, Alison Roth, Shams Ul Mahmood, Tamara Kreiss, Tyler Eck, Mariana Laureano de Souza, John J. Siekierka, Dennis J. Colussi, Patricia J. Lee, Samantha O. Aylor
The discovery of new targets for treatment of malaria and in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f95d28b1facf94164495dca7105a0f
https://doi.org/10.1101/2021.11.05.467463
https://doi.org/10.1101/2021.11.05.467463
Autor:
Mariana Lozano Gonzalez, Dennis J. Colussi, Tyler Eck, Samantha O. Aylor, Patty J. Lee, Shams Ul Mahmood, Tamara Kreiss, David P. Rotella, Brandon S. Pybus, Purnima Bhanot, Wayne E. Childers, John Gordon, Alison Roth, Rammohan R. Yadav Bheemanaboina, M. L. de Souza, John J. Siekierka
The discovery of new targets for treatment of malaria advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection in a murine model. This enthusiasm was temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c612db0e19258f774179b67ca88c35b6
https://doi.org/10.1101/2021.08.24.457553
https://doi.org/10.1101/2021.08.24.457553
Autor:
Narsaiah Battini, Yun-Peng Xie, Gui-Xin Cai, Cheng-He Zhou, Shao-Lin Zhang, Rammohan R. Yadav Bheemanaboina, Wang Liangliang, Mohammad Fawad Ansari, Jin-Ping Chen
Publikováno v:
European Journal of Medicinal Chemistry. 179:166-181
This work did a new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antimicrobial agents. A class of novel hybrids of quinolone, aminothiazole, piperazine and oxime fragments were designed for the first time, convenien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14bcb8d4ab3571811b5f38e427e9c2a
https://doi.org/10.1016/j.ejmech.2019.06.046
https://doi.org/10.1016/j.ejmech.2019.06.046
Autor:
Narsaiah Battini, Rammohan R. Yadav Bheemanaboina, Wang Liangliang, Cheng-He Zhou, Shao-Lin Zhang
Publikováno v:
European Journal of Medicinal Chemistry. 167:105-123
A series of aminothiazolyl norfloxacin analogues as a new type of potential antimicrobial agents were synthesized and screened for their antimicrobial activities. Most of the prepared compounds exhibited excellent inhibitory efficiencies. Especially,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d06bce6635e1ca654a390cd1b91bc8
https://doi.org/10.1016/j.ejmech.2019.01.072
https://doi.org/10.1016/j.ejmech.2019.01.072
Publikováno v:
Molecular Pharmaceutics. 16:1036-1052
Novel sulfonamide-based four-component molecular hybrids as potential DNA-targeting antimicrobial agents were developed from marketed acetanilide through convenient procedures. Biological assays indicated that a few of the target compounds showed sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cedfc14bfeb2d81a344518e32dfb80c
https://doi.org/10.1021/acs.molpharmaceut.8b01021
https://doi.org/10.1021/acs.molpharmaceut.8b01021
Autor:
Narsaiah Battini, Cheng-He Zhou, Hang Sun, Mohammad Fawad Ansari, Rammohan R. Yadav Bheemanaboina
Publikováno v:
Organic Chemistry Frontiers. 6:319-334
A series of berberine-derived thiazolidinediones as novel potential artificial DNA intercalators were developed via five steps from natural berberine. The biological evaluation showed that some of the target molecules exhibited good inhibitory potenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b92d34ecf31aa80c0840fa0a89db3a
https://doi.org/10.1039/c8qo01180j
https://doi.org/10.1039/c8qo01180j
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 64:128695
The dramatic rise in drug resistance accelerated the desire for new antibacterial agents to safeguard human health. This work constructed a novel type of aloe emodin-hybridized sulfonamide aminophosphates as unique potential antibacterial agents. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018e2627080c91f6bf468b353d975147
https://doi.org/10.1016/j.bmcl.2022.128695
https://doi.org/10.1016/j.bmcl.2022.128695