Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ramjit HG"'
Autor:
Kari Vastag, Ramjit Hg, J.J. Lynch, Stephen F. Brady, J. H. Lin, Marie A. Holahan, J. P. Vacca, Maria T. Stranieri, Adel M. Naylor-Olsen, Stephen J. Gardell, Elizabeth A. Lyle, I.-W. Chen, S. D. Lewis, William C. Lumma, Jacquelynn J. Cook, Smith Gm, Bobby J. Lucas, Appleby Sd, K.J. Stauffer
Publikováno v:
Journal of Medicinal Chemistry. 41:401-406
Early studies in these laboratories of peptidomimetic structures containing a basic P1 moiety led to the highly potent and selective thrombin inhibitors 2 (Ki = 5.0 nM) and 3 (Ki = 0.1 nM). However, neither attains significant blood levels upon oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a3426d5efc48772d86fbff9aad61ed
https://doi.org/10.1021/jm9705014
https://doi.org/10.1021/jm9705014
Autor:
Shi-Shan Mao, E P Baskin, Julie A. Krueger, Mark G. Bock, Dong-Mei Feng, A. M. Mulichak, Stephen J. Gardell, Roger M. Freidinger, Lucas R, Ramjit Hg, Jules A. Shafer, S. D. Lewis, R Woltmann, K B Dancheck, Timothy R. Hare, J.J. Lynch, Adel M. Naylor-Olsen, I.-W. Chen, Zhongguo Chen, Joe P. Vacca
Publikováno v:
Journal of Medicinal Chemistry. 40:3726-3733
A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and 14d) showed nanomolar potency (Ki 0.8-12 nM), 300-1500-fold selectivity for thrombin compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a9c3eb4d8f15436d50d759edace5a6
https://doi.org/10.1021/jm970493r
https://doi.org/10.1021/jm970493r
Publikováno v:
Journal of Mass Spectrometry. 31:867-872
A gas chromatographic/mass spectrometric procedure using single-ion monitoring and repetitive scanning was developed to characterize and determine methyl methanesulphonate (MMS) and ethyl methanesulphonate (EMS) in the free base and bismesylate salt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::535d1d8e08100a1aebb2798698649573
https://doi.org/10.1002/(sici)1096-9888(199608)31:8<867::aid-jms362>3.0.co
https://doi.org/10.1002/(sici)1096-9888(199608)31:8<867::aid-jms362>3.0.co
Autor:
Michael J. Salvatore, King Ab, Ramjit Hg, Bartizal Kf, Gill Cj, Keith M. Witherup, Steven M. Pitzenberger, Abruzzo Gk, Onishi Hr, Graham Ac
Publikováno v:
Journal of Natural Products. 61:640-642
Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. This activity is antagonized by mouse plasma, which may account for its lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85563ffc56920d83eb0ee7c7b81ba54
https://doi.org/10.1021/np9703961
https://doi.org/10.1021/np9703961
Autor:
Roger M. Freidinger, Patricia K. Lumma, Ramjit Hg, Deborah Defeo-Jones, Mohinder K. Sardana, Jenny Wai, Oliff Allen I, Raymond E. Jones, Victor M. Garsky, Dong-Mei Feng
Publikováno v:
Journal of medicinal chemistry. 44(24)
Doxorubicin (Dox) can provide some stabilization in prostate cancer; however, its use is limited because of systemic toxicities, primarily cardiotoxicity and immunosuppression. The administration of a prodrug of doxorubicin, designed to permit select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e2b3ba2ef6235523f30eefaa1ebb41
https://pubmed.ncbi.nlm.nih.gov/11708923
https://pubmed.ncbi.nlm.nih.gov/11708923
Autor:
Oliff Allen I, Patricia K. Lumma, Ramjit Hg, Mohinder K. Sardana, Victor M. Garsky, Jenny Wai, Bradley K. Wong, Roger M. Freidinger, Raymond E. Jones, Deborah Defeo-Jones, Dong-Mei Feng
Publikováno v:
Peptides: The Wave of the Future ISBN: 9789401039055
Prostate cancer is the second leading cause of cancer mortality in males. It is estimated that 37,000 men died of prostate carcinoma in the United States in 1999 [1]. While cancer that is confined to the prostate can be treated with surgery or radiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4e4f213c476ad37eb88ad68404cc2f3
https://doi.org/10.1007/978-94-010-0464-0_300
https://doi.org/10.1007/978-94-010-0464-0_300
Autor:
Mohinder K. Sardana, Richard W. Ransom, Keith M. Witherup, Ramjit Hg, Michael J. Bogusky, Paul S. Anderson, Theresa Wood
Publikováno v:
Journal of natural products. 57(12)
A preliminary characterization is provided of a naturally occurring cyclic peptide with interesting and potent biological activity. A 31-residue cyclic peptide, designated cyclopsychotride A [1], was obtained from the organic extract of the tropical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b1e0d549328f65bbf303c5f337cef3
https://pubmed.ncbi.nlm.nih.gov/7714530
https://pubmed.ncbi.nlm.nih.gov/7714530
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