Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ramiro Iglesias‐Bartolome"'
Autor:
Yao Yuan, Jeannie Park, Amber Feng, Parirokh Awasthi, Zhiyong Wang, Qianming Chen, Ramiro Iglesias-Bartolome
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Hippo TEAD-transcriptional regulators YAP1 and TAZ modulate cell growth, but the downstream networks are unclear. Here, the authors use a genetically-encoded inhibitor of YAP1/TAZ interaction with TEAD (TEADi) to disrupt transcriptional networks for
Externí odkaz:
https://doaj.org/article/31dca75ac3144d10befe559d4b9c7055
Autor:
Avinash Das Sahu, Joo S Lee, Zhiyong Wang, Gao Zhang, Ramiro Iglesias‐Bartolome, Tian Tian, Zhi Wei, Benchun Miao, Nishanth Ulhas Nair, Olga Ponomarova, Adam A Friedman, Arnaud Amzallag, Tabea Moll, Gyulnara Kasumova, Patricia Greninger, Regina K Egan, Leah J Damon, Dennie T Frederick, Livnat Jerby‐Arnon, Allon Wagner, Kuoyuan Cheng, Seung Gu Park, Welles Robinson, Kevin Gardner, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, Keith Flaherty, Ji Luo, J Silvio Gutkind, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-21 (2019)
Abstract Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interactions, wh
Externí odkaz:
https://doaj.org/article/3e0d9e37ccd24f31aaa5e8abf6557875
Autor:
Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in
Externí odkaz:
https://doaj.org/article/1b930320d9074414b8a21037b5706075
Autor:
M Pilar Pedro, Katherine Lund, Sun Woo Sophie Kang, Ting Chen, Christina H Stuelten, Natalie Porat-Shliom, Ramiro Iglesias-Bartolome
Publikováno v:
bioRxiv
Epithelial cells in the skin and other tissues rely on signals from their environment to maintain homeostasis and respond to injury, and G protein-coupled receptors (GPCRs) play a critical role in this communication. A better understanding of the GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d742c5ac41ac7b1d5773d4fce79f5cc
https://doi.org/10.1101/2023.05.30.542853
https://doi.org/10.1101/2023.05.30.542853
Autor:
Grace A. Hile, Patrick Coit, Bin Xu, Amanda M. Victory, Mehrnaz Gharaee‐Kermani, Shannon N. Estadt, Mitra P. Maz, Jacob W. S. Martens, Rachael Wasikowski, Craig Dobry, Lam C. Tsoi, Ramiro Iglesias‐Bartolome, Celine C. Berthier, Allison C. Billi, Johann E. Gudjonsson, Amr H. Sawalha, J. Michelle Kahlenberg
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db65ca88f347033bb9cebeec7e5fdfa1
https://doi.org/10.1002/art.42460
https://doi.org/10.1002/art.42460
Autor:
Kata Krizic, Kim B. Jensen, Maria P. Alcolea, Kevin J. Chalut, Seungmin Han, Svetlana Ulyanchenko, Christophe M. Verstreken, Ramiro Iglesias-Bartolome, Jamie McGinn, Adrien Hallou, Benjamin D. Simons, Frances J. England
Publikováno v:
Nature cell biology
Epithelial cells rapidly adapt their behaviour in response to increasing tissue demands. However, the processes that finely control these cell decisions remain largely unknown. The postnatal period covering the transition between early tissue expansi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfe63531b66aaa10489037917b98dbe
https://doi.org/10.1038/s41556-021-00679-w
https://doi.org/10.1038/s41556-021-00679-w
Autor:
Gerald S. Shadel, J. Silvio Gutkind, Rachael E Schwartz, Leonardo R. Andrade, Maxim N. Shokhirev, Ramiro Iglesias-Bartolome
Publikováno v:
Aging (Albany NY)
Senescent cells produce chronic inflammation that contributes to the diseases and debilities of aging. How this process is orchestrated in epithelial cells, the origin of human carcinomas, is poorly understood. We used human normal oral keratinocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd02d5011cfd7556fb3525095f869e5
https://doi.org/10.18632/aging.202658
https://doi.org/10.18632/aging.202658
Publikováno v:
FASEB J
The PKA-inhibitor (PKI) family members PKIα, PKIβ, and PKIγ bind with high affinity to PKA and block its kinase activity, modulating the extent, and duration of PKA-mediated signaling events. While PKA is a well-known regulator of physiological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a780b3a39e07fb44610225983999d8
https://doi.org/10.1096/fj.202001515r
https://doi.org/10.1096/fj.202001515r
Autor:
Jamie McGinn, Maria P. Alcolea, Frances J. England, Christophe M. Verstreken, Svetlana Ulyanchenko, Seungmin Han, Kevin J. Chalut, Adrien Hallou, Ramiro Iglesias-Bartolome, Kim B. Jensen, Kata Krizic, Benjamin D. Simons
Epithelial cells are highly dynamic and can rapidly adapt their behavior in response to tissue perturbations and increasing tissue demands. However, the processes that finely control these responses and, particularly, the mechanisms that ensure the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50af30ab53a0341274b0b5b78c56193
https://doi.org/10.1101/2021.02.03.428820
https://doi.org/10.1101/2021.02.03.428820