Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Ramiro Araya-Maturana"'
Autor:
Diego Méndez, Francisca Tellería, Matías Monroy-Cárdenas, Héctor Montecino-Garrido, Santiago Mansilla, Laura Castro, Andrés Trostchansky, Felipe Muñoz-Córdova, Volker Zickermann, Jonathan Schiller, Sergio Alfaro, Julio Caballero, Ramiro Araya-Maturana, Eduardo Fuentes
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103142- (2024)
Platelets are the critical target for preventing and treating pathological thrombus formation. However, despite current antiplatelet therapy, cardiovascular mortality remains high, and cardiovascular events continue in prescribed patients. In this st
Externí odkaz:
https://doaj.org/article/6360723e01df46fb91276f0e26fc7713
Autor:
Matías Monroy-Cárdenas, Víctor Andrades, Cristopher Almarza, María Jesús Vera, Jorge Martínez, Rodrigo Pulgar, John Amalraj, Ramiro Araya-Maturana, Félix A. Urra
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1597 (2023)
Mitochondrial Complex I plays a crucial role in the proliferation, chemoresistance, and metastasis of breast cancer (BC) cells. This highlights it as an attractive target for anti-cancer drugs. Using submitochondrial particles, we identified FRV–1,
Externí odkaz:
https://doaj.org/article/7be582599e6d4ba1a8ef695290a23627
An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells. This highlights mitochondria as a promising target for new anticancer strategies. Emergent e
Externí odkaz:
https://doaj.org/article/6dba963cdccf4777ae15048caf9d8cfc
Autor:
Dan E. Vivas-Ruiz, Paola Rosas, Alex Proleón, Daniel Torrejón, Fanny Lazo, Ana Belén Tenorio-Ricca, Francisco Guajardo, Cristopher Almarza, Víctor Andrades, Jessica Astorga, Daniel Oropesa, Jorge Toledo, María Jesús Vera, Jorge Martínez, Ramiro Araya-Maturana, Karen Dubois-Camacho, Marcela A. Hermoso, Valéria G. Alvarenga, Eladio Flores Sanchez, Armando Yarlequé, Luciana Souza Oliveira, Félix A. Urra
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1533 (2023)
From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration. In this work, we characterize a novel P-III class snake venom metalloproteinas
Externí odkaz:
https://doaj.org/article/43eed5d3f77f43fea778f614b04bc86b
Autor:
Héctor Montecino-Garrido, Diego Méndez, Ramiro Araya-Maturana, Juan Pablo Millas-Vargas, Sergio Wehinger, Eduardo Fuentes
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Introduction: Obtaining triphenylphosphonium salts derived from anticancer compounds to inhibit mitochondrial metabolism is of major interest due to their pivotal role in reactive oxygen species (ROS) production, calcium homeostasis, apoptosis, and c
Externí odkaz:
https://doaj.org/article/6930a693e5f94b82a975b141b79dc889
Autor:
Francisca Tellería, Santiago Mansilla, Diego Méndez, Magdalena Sepúlveda, Ramiro Araya-Maturana, Laura Castro, Andrés Trostchansky, Eduardo Fuentes
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 210 (2023)
Although platelets are anucleated cells, they have fully functional mitochondria, and currently, it is known that several processes that occur in the platelet require the action of mitochondria. There are plenty of mitochondrial-targeted compounds de
Externí odkaz:
https://doaj.org/article/5d2c727e03d94c37b3958964edd70bfb
Autor:
Félix A. Urra, Sebastián Fuentes-Retamal, Charlotte Palominos, Yarcely A. Rodríguez-Lucart, Camila López-Torres, Ramiro Araya-Maturana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The role of metabolism in tumor growth and chemoresistance has received considerable attention, however, the contribution of mitochondrial bioenergetics in migration, invasion, and metastasis is recently being understood. Migrating cancer cells adapt
Externí odkaz:
https://doaj.org/article/91ca909e0a034c0285079caac23358c5
Autor:
Oscar Forero-Doria, Luis Guzmán, Felipe Jiménez-Aspee, Javier Echeverría, Sergio Wehinger, Claudio Valenzuela, Ramiro Araya-Maturana, Maximiliano Martínez-Cifuentes
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1104 (2022)
In this work, we report the synthesis of curcuminoids with ionic liquid characteristics, obtained by incorporating alkyl-substituted pyridinium moiety rather than one phenyl group through a two-step process. The antioxidant capacity of the obtained c
Externí odkaz:
https://doaj.org/article/7aa009af74754b1cacd2c7c9ebdc9a8f
Autor:
Matías Monroy-Cárdenas, Diego Méndez, Andrés Trostchansky, Maximiliano Martínez-Cifuentes, Ramiro Araya-Maturana, Eduardo Fuentes
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
We designed and synthesized in water, using conventional heating and microwave irradiation, new thio-derivatives of 2-hydroxy-1,4-naphthoquinone, a naturally occurring pigment known as lawsone or hennotannic acid, thus improving their antiplatelet ac
Externí odkaz:
https://doaj.org/article/1ec23a5159184cf79c6723a8bb7f0ab6
Autor:
Miguel Córdova-Delgado, Sebastián Fuentes-Retamal, Charlotte Palominos, Camila López-Torres, Daniela Guzmán-Rivera, Oney Ramírez-Rodríguez, Ramiro Araya-Maturana, Félix A. Urra
Publikováno v:
Antioxidants, Vol 10, Iss 10, p 1618 (2021)
Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery. FRI-1, methyl 1, 3-dimethyl-5, 8-dioxo-5,
Externí odkaz:
https://doaj.org/article/d0d7417f6eb44944b75f7b26365907b1