Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Ramiro, Alberio"'
Autor:
Luke Simpson, Andrew Strange, Doris Klisch, Sophie Kraunsoe, Takuya Azami, Daniel Goszczynski, Triet Le Minh, Benjamin Planells, Nadine Holmes, Fei Sang, Sonal Henson, Matthew Loose, Jennifer Nichols, Ramiro Alberio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here we present a single-cell transcri
Externí odkaz:
https://doaj.org/article/77cd741060604021a8d47cf08dd866e3
Autor:
Ryan P Cardenas, Ahmad Zyoud, Alan McIntyre, Ramiro Alberio, Nigel P Mongan, Cinzia Allegrucci
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs can be traced back to p
Externí odkaz:
https://doaj.org/article/3f6513a630da48609db4b1336e689638
Autor:
Luke A Simpson, Darren Crowley, Teri Forey, Helena Acosta, Zoltan Ferjentsik, Jodie Chatfield, Alexander Payne, Benjamin S Simpson, Catherine Redwood, James E Dixon, Nadine Holmes, Fei Sang, Ramiro Alberio, Matthew Loose, Andrew D Johnson
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002121 (2023)
Pluripotency defines the unlimited potential of individual cells of vertebrate embryos, from which all adult somatic cells and germ cells are derived. Understanding how the programming of pluripotency evolved has been obscured in part by a lack of da
Externí odkaz:
https://doaj.org/article/e160f857ecb94e4e8ba33d07731a5033
Publikováno v:
Biology Open, Vol 10, Iss 10 (2021)
In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of
Externí odkaz:
https://doaj.org/article/ade452b7c95e4f6894b57d5e56f18834
Autor:
Priscila Ramos-Ibeas, Fei Sang, Qifan Zhu, Walfred W. C. Tang, Sarah Withey, Doris Klisch, Liam Wood, Matt Loose, M. Azim Surani, Ramiro Alberio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Lineage segregation from conception to gastrulation has been mapped at the single cell level in mouse, human and monkey. Here, the authors provide a comprehensive analysis of porcine preimplantation development using single cell RNA-seq; mapping meta
Externí odkaz:
https://doaj.org/article/aa29d00c859347f6bccca210653ecca1
Autor:
Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E. Requena, Petra Hajkova, Matt Loose, M. Azim Surani, Ramiro Alberio
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108735- (2021)
Summary: Investigations of the human germline and programming are challenging because of limited access to embryonic material. However, the pig as a model may provide insights into transcriptional network and epigenetic reprogramming applicable to bo
Externí odkaz:
https://doaj.org/article/eb691efd76104f4a97615cd06174a463
Autor:
Jesica R. Canizo, Camila Vazquez Echegaray, Doris Klisch, Juan F. Aller, Dante A. Paz, Ricardo H. Alberio, Ramiro Alberio, Alejandra S. Guberman
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-8 (2018)
Abstract Objectives The use of induced pluripotent stem (iPS) cells as an alternative to embryonic stem cells to produce transgenic animals requires the development of a biotechnological platform for their generation. In this study, different strateg
Externí odkaz:
https://doaj.org/article/f9c1bb1ba67444f3a16acabb3c5b1dca
Autor:
Lucy F Donaldson, Ramiro Alberio, Jennifer Batson, Frances Henson, Roger Lemon, Anna Mitchell, Jo Murrell, Domingo Tortonese
Publikováno v:
Physiology News. :18-22
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are t
Externí odkaz:
https://doaj.org/article/7e40643bf35d4e48a0c30bfe6f675ead
Autor:
Ramiro Alberio, Navin Ramakrishna
Publikováno v:
Development. 149