Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ramin Sakhtemani"'
Autor:
Yasha Butt, Ramin Sakhtemani, Rukshana Mohamad-Ramshan, Michael S. Lawrence, Ashok S. Bhagwat
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The APOBEC3 enzymes convert cytosines in single-stranded DNA to uracils to protect against viruses and retrotransposons but can contribute to mutations that diversify tumors. To understand the mechanism of mutagenesis, we map the uracils res
Externí odkaz:
https://doaj.org/article/820624b331134de1a53888915fff2f2b
Autor:
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S. Chen, Reuben S. Harris, Michael S. Lawrence, Rémi Buisson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that a
Externí odkaz:
https://doaj.org/article/242d0a53917f49e5bc6d9be8d45bb23e
Autor:
Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The APOBEC mutation signature contributes to a significant percentage of human cancers. Here the authors via biochemical and computational analyses shed light on how DNA primary sequence and secondary structure jointly influence A3A substrate optimal
Externí odkaz:
https://doaj.org/article/0df7d51a696e4dfaa11c6266dbb37d50
A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers.
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185010 (2017)
Most B cell cancers overexpress the enzyme activation-induced deaminase at high levels and this enzyme converts cytosines in DNA to uracil. The constitutive expression of this enzyme in these cells greatly increases the uracil content of their genome
Externí odkaz:
https://doaj.org/article/4f4fe82052ae4e32bfee8ea4e7590c50
Mutation calls from cell line samples. (Supplementary Table 6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e2db51511e619979354ed4563ad2e4
Autor:
Ramin Sakhtemani, Madusha L W Perera, Daniel Hübschmann, Reiner Siebert, Michael S Lawrence, Ashok S Bhagwat
Publikováno v:
Nucleic Acids Research. 50:5145-5157
Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand bre
Autor:
Justin F. Gainor, Alexander Drilon, Aaron N. Hata, Sai-Hong Ignatius Ou, Michael S. Lawrence, Alice T. Shaw, Jochen K. Lennerz, Beow Y. Yeap, Lecia V. Sequist, Jennifer S. Temel, Christina J. Falcon, Adam J. Schoenfeld, Adam Langenbucher, Harper G. Hubbeling, Wafa Malik, Kylie Prutisto-Chang, Jennifer Peterson, Andrew Do, Charlotte Lee, Subba R. Digumarthy, Ibiayi Dagogo-Jack, Ramin Sakhtemani, Ted W. Johnson, Viola W. Zhu, Satoshi Yoda, Noura J. Choudhury, Jessica J. Lin
Supplementary Tables 1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5b19d00684fec600f7f9f19f325d89
https://doi.org/10.1158/1078-0432.22478825
https://doi.org/10.1158/1078-0432.22478825
Autor:
Justin F. Gainor, Alexander Drilon, Aaron N. Hata, Sai-Hong Ignatius Ou, Michael S. Lawrence, Alice T. Shaw, Jochen K. Lennerz, Beow Y. Yeap, Lecia V. Sequist, Jennifer S. Temel, Christina J. Falcon, Adam J. Schoenfeld, Adam Langenbucher, Harper G. Hubbeling, Wafa Malik, Kylie Prutisto-Chang, Jennifer Peterson, Andrew Do, Charlotte Lee, Subba R. Digumarthy, Ibiayi Dagogo-Jack, Ramin Sakhtemani, Ted W. Johnson, Viola W. Zhu, Satoshi Yoda, Noura J. Choudhury, Jessica J. Lin
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9ca50fde65b62aaec84f5f254dafcb
https://doi.org/10.1158/1078-0432.22478831.v1
https://doi.org/10.1158/1078-0432.22478831.v1
Autor:
Justin F. Gainor, Alexander Drilon, Aaron N. Hata, Sai-Hong Ignatius Ou, Michael S. Lawrence, Alice T. Shaw, Jochen K. Lennerz, Beow Y. Yeap, Lecia V. Sequist, Jennifer S. Temel, Christina J. Falcon, Adam J. Schoenfeld, Adam Langenbucher, Harper G. Hubbeling, Wafa Malik, Kylie Prutisto-Chang, Jennifer Peterson, Andrew Do, Charlotte Lee, Subba R. Digumarthy, Ibiayi Dagogo-Jack, Ramin Sakhtemani, Ted W. Johnson, Viola W. Zhu, Satoshi Yoda, Noura J. Choudhury, Jessica J. Lin
Supplementary methods, figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e82d757e4978f6be4f2a06e2e25469
https://doi.org/10.1158/1078-0432.22478828
https://doi.org/10.1158/1078-0432.22478828
Autor:
Justin F. Gainor, Alexander Drilon, Aaron N. Hata, Sai-Hong Ignatius Ou, Michael S. Lawrence, Alice T. Shaw, Jochen K. Lennerz, Beow Y. Yeap, Lecia V. Sequist, Jennifer S. Temel, Christina J. Falcon, Adam J. Schoenfeld, Adam Langenbucher, Harper G. Hubbeling, Wafa Malik, Kylie Prutisto-Chang, Jennifer Peterson, Andrew Do, Charlotte Lee, Subba R. Digumarthy, Ibiayi Dagogo-Jack, Ramin Sakhtemani, Ted W. Johnson, Viola W. Zhu, Satoshi Yoda, Noura J. Choudhury, Jessica J. Lin
Purpose:Current standard initial therapy for advanced, ROS proto-oncogene 1, receptor tyrosine kinase fusion (ROS1)-positive (ROS1+) non–small cell lung cancer (NSCLC) is crizotinib or entrectinib. Lorlatinib, a next-generation anaplastic lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5172c89aba121b65d81b64c96d23e465
https://doi.org/10.1158/1078-0432.c.6530057.v1
https://doi.org/10.1158/1078-0432.c.6530057.v1