Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ramila Shah"'
Autor:
Ghislaine Fontés, Ramila Shah, Derek K. Hagman, Christopher J. Rhodes, Meriem Semache, Vincent Poitout, Caroline Tremblay, Jared Rutter
Publikováno v:
Diabetes
OBJECTIVE Prolonged exposure of pancreatic β-cells to simultaneously elevated levels of fatty acids and glucose (glucolipotoxicity) impairs insulin gene transcription. However, the intracellular signaling pathways mediating these effects are mostly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c95d18ea493404cc388dad004e85ad6
http://europepmc.org/articles/PMC2731539
http://europepmc.org/articles/PMC2731539
Autor:
Tiphanie Phillips, Ramila Shah, Ni Liu, Joseph T. Opferman, Christopher J. Froelich, Philip G. Ashton-Rickardt
Publikováno v:
The Journal of Immunology. 173:3801-3809
Generation and maintenance of protective immunological memory is the goal of vaccination programs. It has recently become clear that CD8+ memory T cells are derived directly from CTLs. The mechanisms underlying this transformation and the subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcddfc38229961647d88ff9f4f6a6fb
https://doi.org/10.4049/jimmunol.173.6.3801
https://doi.org/10.4049/jimmunol.173.6.3801
Autor:
Ni Liu, Manling Zhang, Yue Wang, Joseph T Opferman, Tiphanie Phillips, Philip G. Ashton-Rickardt, Ramila Shah
Publikováno v:
Nature Immunology. 5:919-926
An essential event in the development of memory CD8(+) T lymphocytes is the escape of progenitors from programmed cell death, but how this is mediated is unclear. Here we report that the gene encoding serine protease inhibitor 2A (Spi2A), an inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621fbcf68cb71fd728c503c96c23f0f5
https://doi.org/10.1038/ni1107
https://doi.org/10.1038/ni1107
Publikováno v:
Diabetes
OBJECTIVE Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet β-cells by promoting growth and survival. IRS-2 turnover is rapid in primary β-cells, but its expression is highly regulated at the transcriptional level, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc487d310d81191bdcaa20dde1bc3fe
https://pubmed.ncbi.nlm.nih.gov/21940781
https://pubmed.ncbi.nlm.nih.gov/21940781
Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells
Publikováno v:
Journal of immunological methods. 331(1-2)
Conditional gene deletion using lineage-specific transgenic expression of Cre has been useful for defining the role of specific gene products in mice in vivo. However, this technology has had limitations for studies of peripheral T cell biology, sinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ee0a1223bc2297d4b7573d11bae588
https://pubmed.ncbi.nlm.nih.gov/18177887
https://pubmed.ncbi.nlm.nih.gov/18177887
Autor:
Manling Zhang, Sun Mi Park, Philip G. Ashton-Rickardt, Yue Wang, Marcus E. Peter, Chyung Ru Wang, Ramila Shah, Ni Liu, Andrea E. Murmann
Publikováno v:
Immunity. 24(4)
SummaryHow cytotoxic T lymphocytes (CTLs) kill intracellular pathogens without killing themselves has been a recurring question ever since their discovery. By using mice deficient in Serine Protease Inhibitor 6 (Spi6), we show that by inhibiting gran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc371a18cbbaf2378d80b434b3610c24
https://pubmed.ncbi.nlm.nih.gov/16618603
https://pubmed.ncbi.nlm.nih.gov/16618603
Autor:
Yue Wang, Sunil S. Metkar, Philip G. Ashton-Rickardt, Manling Zhang, Ni Liu, Christopher J. Froelich, Srikumar M. Raja, Guido Franzoso, Marcus E. Peter, Francesca Zazzeroni, William A. Russin, Dieter Brömme, Justine C. Lee, Ramila Shah
Publikováno v:
The EMBO journal. 22(19)
The programme of gene expression induced by RelA/NF-kappaB transcription factors is critical to the control of cell survival. Ligation of 'death receptors' such as tumor necrosis factor receptor 1 (TNF-R1) triggers apoptosis, as well as NF-kappaB, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddba72770fe2f6ccbd0baf900e7e44d
https://pubmed.ncbi.nlm.nih.gov/14517268
https://pubmed.ncbi.nlm.nih.gov/14517268
Publikováno v:
Cellular immunology. 166(1)
Rat T cells reactive against myelin basic protein (MBP) are exclusively, CD4+ CD8- CD45RC-, inevitably produce abundant IFN-gamma, and appear to correspond to members of the Th1 CD4+ T cell subset characterized in mice. To ascertain the basis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49e1738a12ff6b5b551bf044c264908
https://pubmed.ncbi.nlm.nih.gov/7585969
https://pubmed.ncbi.nlm.nih.gov/7585969
Publikováno v:
Cellular immunology. 156(2)
Reports of the expression of very similar TCR structures by disparate rodent encephalitogenic T cells reactive with regions of MBP have aroused much interest for both theoretical and practical reasons. To ascertain the extent to which structural requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdc80e70a501f64de7724e107d81164
https://pubmed.ncbi.nlm.nih.gov/7517795
https://pubmed.ncbi.nlm.nih.gov/7517795