Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ramila E. Gulieva"'
Autor:
Sienna R. Li, Ramila E. Gulieva, Louisa Helms, Nelly M. Cruz, Thomas Vincent, Hongxia Fu, Jonathan Himmelfarb, Benjamin S. Freedman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules. Here the authors show that subjecting organoids to fluid shear stress in a PKD-on-a-chip microphysiological system promotes cyst expansion via an absorptive pathway.
Externí odkaz:
https://doaj.org/article/c46ae4379a784182858157d336548bc7
Autor:
Tania García-Martínez, Teresa Mogas, Steven F. Mullen, Iris Martínez-Rodero, Ramila E. Gulieva, Adam Z. Higgins
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The plasma membrane permeability to water and cryoprotectant (CPA) significantly impacts vitrification efficiency of bovine oocytes. Our study was designed to determine the concentration-dependent permeability characteristics for immature (G
Externí odkaz:
https://doaj.org/article/f47b10002b8a48829e4f8226f2522032
Autor:
Ramila E. Gulieva, Tania García-Martínez, Adam Z. Higgins, Teresa Mogas, Iris Martínez-Rodero, Steven F. Mullen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
The plasma membrane permeability to water and cryoprotectant (CPA) significantly impacts vitrification efficiency of bovine oocytes. Our study was designed to determine the concentration-dependent permeability characteristics for immature (GV) and ma
Autor:
Adam Z. Higgins, Ramila E. Gulieva
Publikováno v:
Cryobiology. 103
The ability to cryopreserve organs would have an enormous impact in transplantation medicine. To investigate organ cryopreservation strategies, experiments are typically done on whole organs, or on cells in 2D culture. Whole organs are not amenable t
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease
Autor:
York Pei, Laura S. Finn, Jonathan Himmelfarb, Ramila E. Gulieva, Nelly M. Cruz, Benjamin S. Freedman, Angela J. Churchill, Yong Kyun Kim, Hongxia Fu, Linh M. Tran, Xuewen Song, Marco A. Diaz, Kosuke Winston, Stefan Czerniecki
Publikováno v:
Nature materials
Tissue mimics are of great interest in understanding diseases. Here, organoids were developed that resemble polycystic kidney disease cysts and it was demonstrated how material environment and adhesion can affect cystogenesis and disease progression.
Autor:
Stuart J. Shankland, Michael R. Hughes, Ido Refaeli, Peifeng Jing, Angela J. Churchill, Lih Y. Lin, Yong Kyun Kim, Jeffrey W. Pippin, Yuliang Wang, A. Wayne Vogl, Nelly M. Cruz, Ramila E. Gulieva, Kelly M. McNagny, Yannan Liu, Hongxia Fu, Benjamin S. Freedman, Craig R. Brooks
Publikováno v:
Stem Cells. 35:2366-2378
A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem cells (hPSC-podocytes) have recently been generated i
Autor:
James D. Benson, Emi Ampo, Yong How Tan, Ross Warner, Adam Z. Higgins, Taylor Kuntz, Ali Eroglu, Ramila E. Gulieva, Dylan Nelson
Publikováno v:
Cryobiology. 97:291
Autor:
Ramila E. Gulieva, Adam Z. Higgins
Publikováno v:
Cryobiology. 97:263
Autor:
Ramila E. Gulieva, Linh M. Tran, Laura V. Islas, Hongxia Fu, Randall T. Moon, Jennifer L. Harder, Rajasree Menon, Edgar A. Otto, Matthias Kretzler, Benjamin S. Freedman, Nelly M. Cruz, Yong Kyun Kim, Neal Paragas, James Annis, Timothy J. Martins, Jonathan Himmelfarb, Stefan Czerniecki, Stuart J. Shankland, Jeffrey W. Pippin
Publikováno v:
Cell stem cell. 22(6)
Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a full