Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Rami Yaka"'
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Addiction is a complex behavioral disorder characterized by compulsive drug-seeking and drug use despite harmful consequences. The prefrontal cortex (PFC) plays a crucial role in cocaine addiction, involving decision-making, impulse control,
Externí odkaz:
https://doaj.org/article/0bf2396788144314a3b120fe7f72ff78
Autor:
Alaa Khayat, Rami Yaka
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The nucleus accumbens (NAc) and the ventral tegmental area (VTA) are integral brain regions involved in reward processing and motivation, including responses to drugs of abuse. Previously, we have demonstrated that activation of NAc-VTA afferents dur
Externí odkaz:
https://doaj.org/article/bbffe012d1664bba931c13337a215da3
Autor:
Samah Shahen-Zoabi, Reem Smoum, Alexey Bingor, Etty Grad, Alina Nemirovski, Tawfeeq Shekh-Ahmad, Raphael Mechoulam, Rami Yaka
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract The endocannabinoid system (ECS) plays a key modulatory role during synaptic plasticity and homeostatic processes in the brain and has an important role in the neurobiological processes underlying drug addiction. We have previously shown tha
Externí odkaz:
https://doaj.org/article/e5e1f249c9224f58a2b1879e70fd43fd
Autor:
Tehila Beiser, Elvira Lisniansky, Moriya Weitz, Alexey Bingor, Etty Grad, Kobi Rosenblum, Claire Thornton, Rami Yaka
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate, eEF2. However, the involvement of the eEF2 pathway in cocaine-induced neuroadaptations and co
Externí odkaz:
https://doaj.org/article/91ff8002476641768e381b92f401b712
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Zeta inhibitory peptide (ZIP) impairs the maintenance of acquired memories. ZIP is known as an inhibitor of PKMζ. Here, the authors unveil how ZIP impairs memory maintenance acting as an arginine donor, facilitating NO-dependent down-regulation of A
Externí odkaz:
https://doaj.org/article/01bc7875739f4b9686cb40eec93d2553
Autor:
Rami Yaka, Samah Shahen-Zoabi, Reem Smoum, Alexey Bingor, Etty Grad, Alina Nemirovski, Tawfeeq Shekh-Ahmad, Raphael Mechoulam
The endocannabinoid system (ECS) plays a key modulatory role during synaptic plasticity and homeostatic processes in the brain, and has an important role in the neurobiological processes underlying drug addiction. We have previously shown that an ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28aedb86b20eed492b551ecf31f1e15e
https://doi.org/10.21203/rs.3.rs-2503793/v1
https://doi.org/10.21203/rs.3.rs-2503793/v1
Autor:
Samah Shahen-Zoabi, Reem Smoum, Tehila Beiser, Alina Nemirovski, Raphael Mechoulam, Rami Yaka
Publikováno v:
Cannabis and cannabinoid research.
Publikováno v:
Journal of Molecular Neuroscience
Among the neuroadaptations underlying the expression of cocaine-induced behaviors are modifications in glutamate-mediated signaling and synaptic plasticity via activation of mitogen-activated protein kinases (MAPKs) within the nucleus accumbens (NAc)
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Zeta inhibitory peptide (ZIP), a PKMζ inhibitor, is widely used to interfere with the maintenance of acquired memories. ZIP is able to erase memory even in the absence of PKMζ, via an unknown mechanism. We found that ZIP induces redistribution of t
Publikováno v:
Addiction Biology. 26
Elevated dopamine (DA) levels in the reward system underlie various drug-related behaviors, including addiction. As a major DA source in the reward system, the ventral tegmental area (VTA) is highly regulated by GABAergic inputs projected from differ