Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster

Autor: Janis M. O'Donnell, Xandra O. Breakefield, Noriko Wakabayashi-Ito, Olugbenga M. Doherty, Benjamin W. Henderson, Rami R. Ajjuri, Naoto Ito

Publikováno v: Biology Open, Vol 4, Iss 5, Pp 585-595 (2015)
Biology Open

Dystonia represents the third most common movement disorder in humans with over 20 genetic loci identified. TOR1A (DYT1), the gene responsible for the most common primary hereditary dystonia, encodes torsinA, an AAA ATPase family protein. Most cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c22a2a14146cd4e43fb44d6967903f2
http://bio.biologists.org/content/4/5/585

Contributors

Autor: Rami R. Ajjuri, Yousuf Ali, Giuseppe Arena, Tetsuo Ashizawa, Georg Auburger, Devika P. Bagchi, Barbara Baldo, Sally L. Baxter, Robert F. Berman, Lester I. Binder, Craig Blackstone, Carlo Breda, Jonathan M. Brotchie, Edward A. Burton, Diany Paola Calderon, Guy A. Caldwell, Kim A. Caldwell, M. Angela Cenci, Jianmin Chen, Marie-Francoise Chesselet, Lyndsey E. Collins-Praino, Carlo Colosimo, Benjamin Combs, Mercè Correa, Maria Cristina D’Adamo, Helena Dai, Debkanya Datta, Mark P. DeAndrade, Paula Dietrich, Ioannis Dragatsis, David Eidelberg, Sherif F. El-Khamisy, Craig L. Evinger, Coralie Fassier, Maciej Figiel, Susan H. Fox, Veronica Francardo, Amanda A.H. Freeman, Steven Frucht, John Gardiner, Benoit Giasson, Flaviano Giorgini, Suzana Gispert, Pilar González-Cabo, Viviana Gradinaru, Marleshia Hall, Hiroko Hama, Adrian Handforth, Susan Hayflick, Jamilé Hazan, Peter Hedera, Gary A. Heiman, Karl Herrup, Ellen J. Hess, Patrick Hickey, Diana S. Himmelstein, Pieter J. Hoekstra, Corinne Houart, Michael Ryan Hunsaker, Hanna Iderberg, Vernic Jackson-Lewis, Joseph Jankovic, H.A. Jinnah, Tarja Joensuu, Tom M. Johnston, Keith A. Josephs, Nicholas M. Kanaan, Kamran Khodakhah, Kwang-Soo Kim, F. Klinker, Gurdeep S. Kooner, Outi Kopra, Paul T. Kotzbauer, Elena Kozina, Florian Krismer, Wlodzimierz J. Krzyzosiak, Korah P. Kuruvilla, Daniela Kuzdas, Charalambos P. Kyriacou, Blair R. Leavitt, Mark S. LeDoux, Anna-Elina Lehesjoki, Deranda Lester, Jada Lewis, Jiali Li, D. Liebetanz, Hanna Lindgren, Giovanna R. Mallucci, Amandeep Mann, Russell L. Margolis, Robert P. Mason, Gelareh Mazarei, Michael P. McDonald, Judith Melki, Aurélie Méneret, Mariana Moscovich, Irene Neuner, Janis M. O’Donnell, Janneth Oleas, William G. Ondo, Puneet Opal, Harry T. Orr, Emily F. Ozdowski, Massimo Pandolfo, Peristera Paschou, Juan M. Pascual, Amar Patel, Neepa Patel, João N. Peres, Mauro Pessia, Åsa Petersén, Simona Petrucci, Ronald F. Pfeiffer, Nicolás M. Phielipp, Ilse Sanet Pienaar, Christopher Pittenger, Mark R. Plummer, Samantha Podurgiel, Serge Przedborski, Andreas Puschmann, Lawrence T. Reiter, Yan Ren, Benoît Renvoisé, Samuel J. Rose, Owen A. Ross, Emmanuel Roze, Kai Ruan, Dobrila D. Rudnicki, Naruhiko Sahara, Wataru Sako, John D. Salamone, Subhabrata Sanyal, Thomas L. Saunders, Susanne A. Schneider, Eva C. Schulte, Jared J. Schwartzer, Nina T. Sherwood, Ody Sibon, Richard J. Smeyne, Mark Stacy, Philip Starr, Brian E. Staveley, Nadia Stefanova, S.H. Subramony, Nicole Swann, Pawel M. Switonski, Wojciech J. Szlachcic, Kwok-Keung Tai, Valeria Tiranti, Daniel D. Truong, Henna Tyynismaa, Aziz M. Uluğ, Enza M. Valente, Jay A. Van Gerpen, Rafael P. Vázquez-Manrique, Satya Vemula, Marie Vidailhet, Ruth H. Walker, Sarah M. Ward, Owen S. Wells, Gregor K. Wenning, Kathleen A. Willet, Juliane Winkelmann, Zbigniew K. Wszolek, Jianfeng Xiao, X. William Yang, Emil Ylikallio, Fumiaki Yokoi, Zhenyu Yue, R. Grace Zhai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cb6b796146860f53192cc50e4f17a42
https://doi.org/10.1016/b978-0-12-405195-9.01002-7

Novel Whole-tissue Quantitative Assay of Nitric Oxide Levels in Drosophila Neuroinflammatory Response

Autor: Janis M. O'Donnell, Rami R. Ajjuri

Publikováno v: Journal of Visualized Experiments.

Neuroinflammation is a complex innate immune response vital to the healthy function of the central nervous system (CNS). Under normal conditions, an intricate network of inducers, detectors, and activators rapidly responds to neuron damage, infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee3a03cf95cd3189ed730a296411b80
https://doi.org/10.3791/50892-v